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Kupryashov A.A.

Bakulev National Medical Research Center for Cardiovascular Surgery

Rivnyak M.I.

Bakulev National Medical Research Center for Cardiovascular Surgery

Samuilova D.S.

Bakulev National Medical Research Center for Cardiovascular Surgery

Kchicheva G.A.

Bakulev National Medical Research Center for Cardiovascular Surgery

Kuksina E.V.

Bakulev National Medical Research Center for Cardiovascular Surgery

Zhemarina I.B.

Bakulev National Medical Research Center for Cardiovascular Surgery

Hypoxic regulation of erythropoietin secretion in heart failure patients undergoing elective surgery under cardiopulmonary bypass

Authors:

Kupryashov A.A., Rivnyak M.I., Samuilova D.S., Kchicheva G.A., Kuksina E.V., Zhemarina I.B.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(6): 693‑702

DOI: 10.17116/kardio202518061693

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Table of contents

HYPOXIC REGULATION OF ERYTHROPOIETIN SECRETION IN HEART FAILURE PATIENTS UNDERGOING ELECTIVE SURGERY UNDER CARDIOPULMONARY BYPASS
HYPOXIC REGULATION OF ERYTHROPOIETIN SECRETION IN HEART FAILURE PATIENTS UNDERGOING ELECTIVE SURGERY UNDER CARDIOPULMONARY BYPASS

To cite this article:

Kupryashov AA, Rivnyak MI, Samuilova DS, Kchicheva GA, Kuksina EV, Zhemarina IB. Hypoxic regulation of erythropoietin secretion in heart failure patients undergoing elective surgery under cardiopulmonary bypass. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(6):693‑702. (In Russ., In Engl.)
https://doi.org/10.17116/kardio202518061693

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
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Abstract:

OBJECTIVE

To determine the relationship between severity of hypoxia and EPO production in heart failure (HF) candidates listed for surgery under cardiopulmonary bypass.

MATERIAL AND METHODS

A prospective cohort study included 29 patients with HF resulting from heart valve disease and/or coronary artery disease. Cardiopulmonary exercise test (CPET), serum EPO and O/P ratio (ratio of observed to predicted logEPO) were analyzed to compare severity of hypoxia and EPO release.

RESULTS

Serum EPO and O/P ratio were not associated with hematologic parameters and serum B-type natriuretic peptide (BNP). Minute ventilation/carbon dioxide production (VE/VCO2) was predicted by EPO level, hemoglobin level, O/P ratio, end-systolic volume, end-diastolic volume and left ventricular ejection fraction. In multivariate model, VE/VCO2 was predicted by serum EPO. EPO<16.8 IU/mL indicated higher peak oxygen consumption (VO2 peak), higher carbon dioxide (CO2) production, improved exercise tolerance, and better postoperative outcomes.

CONCLUSION

Serum EPO in patients with heart failure can be an objective criterion for severity of circulatory hypoxia.

Keywords:

congestive heart failure
hypoxia
hematopoiesis
erythropoietin
anemia
exercise capacity
cardiopulmonary bypass

Authors:

Kupryashov A.A.

Bakulev National Medical Research Center for Cardiovascular Surgery

Rivnyak M.I.

Bakulev National Medical Research Center for Cardiovascular Surgery

Samuilova D.S.

Bakulev National Medical Research Center for Cardiovascular Surgery

Kchicheva G.A.

Bakulev National Medical Research Center for Cardiovascular Surgery

Kuksina E.V.

Bakulev National Medical Research Center for Cardiovascular Surgery

Zhemarina I.B.

Bakulev National Medical Research Center for Cardiovascular Surgery

Received:

08.08.2024

Accepted:

05.11.2024

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References:

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