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Lastochkina D.V.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Krobinets I.I.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Zenina M.N.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency;
I.I. Mechnikov North-Western State Medical University

Grishina G.V.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Nuzhdina M.A.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Sidorkevich S.V.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Gaykovaya L.B.

I.I. Mechnikov North-Western State Medical University

Erythrocyte indices — markers for the diagnosis of blood iron deficiency in donors

Authors:

Lastochkina D.V., Krobinets I.I., Zenina M.N., Grishina G.V., Nuzhdina M.A., Sidorkevich S.V., Gaykovaya L.B.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(6): 88‑91

DOI: 10.17116/profmed20252806188

Read: 677 times

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Table of contents

ERYTHROCYTE INDICES — MARKERS FOR THE DIAGNOSIS OF BLOOD IRON DEFICIENCY IN DONORS
ERYTHROCYTE INDICES — MARKERS FOR THE DIAGNOSIS OF BLOOD IRON DEFICIENCY IN DONORS

To cite this article:

Lastochkina DV, Krobinets II, Zenina MN, Grishina GV, Nuzhdina MA, Sidorkevich SV, Gaykovaya LB. Erythrocyte indices — markers for the diagnosis of blood iron deficiency in donors. Russian Journal of Preventive Medicine. 2025;28(6):88‑91. (In Russ.)
https://doi.org/10.17116/profmed20252806188

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Blood donors have a high prevalence of iron deficiency.

OBJECTIVE

To evaluate using some indices to diagnose iron deficiency in donors’ blood.

MATERIALS AND METHODS

Whole blood donors were included in the study. Additional erythrocyte indices were measured in them, which are used primarily in scientific research and represent promising indicators for verifying iron deficiency, such as low hemoglobin content (LHC), microcytic anemia factor (MAF), erythrocyte size factor, and serum ferritin level. The control group included first-time blood donors (primary donors). ROC analysis was performed to determine the diagnostic value of erythrocyte indices.

RESULTS

Significant differences were found for all laboratory tests. Iron deficiency was detected in 52% of donors, and the median serum ferritin level was 18.6 ng/mL. When determining the diagnostic value of erythrocyte indices, the threshold value for LHC was 2.95% and 12.5 for the MAF index; both had a high sensitivity and specificity.

CONCLUSION

Erythrocyte indices are informative parameters in the early diagnosis of iron deficiency in blood donors.

Keywords:

donor
iron deficiency
blood donation
anemia
erythrocyte index
iron deficiency anemia

Authors:

Lastochkina D.V.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Krobinets I.I.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Zenina M.N.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency;
I.I. Mechnikov North-Western State Medical University

Grishina G.V.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Nuzhdina M.A.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Sidorkevich S.V.

Russian Research Institute of Hematology and Transfusiology of the Federal Medical-Biological Agency

Gaykovaya L.B.

I.I. Mechnikov North-Western State Medical University

Received:

20.03.2025

Accepted:

04.04.2025

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References:

  1. Fillet AM, Martinaud C, Malard L, et al. Iron deficiency among French whole-blood donors: first assessment and identification of predictive factors. Vox Sanguinis. 2021;116(1):42-52.  https://doi.org/10.1111/vox.12991
  2. Urrechaga E. The new mature red cell parameter, low haemoglobin density of the Beckman-coulter LH750: clinical utility in the diagnosis of iron deficiency. International Journal of Laboratory Hematology. 2010;32(1 PART.1):e144-e150. https://doi.org/10.1111/j.1751-553X.2008.01127.x
  3. Farrag K, Ademaj K, Leventi E, et al. Diagnostic utility of low hemoglobin density to detect iron deficiency in patients with inflammatory bowel disease. Annals of Gastroenterology. 2021;34(4):521-527.  https://doi.org/10.20524/aog.2021.0622
  4. Lv J, Li J, Ren X, et al. Differentiation between Thalassemia Trait and Iron Deficiency Anemia Based on Low Hemoglobin Density and Microcytic Anemia Factor. Clinical Laboratory. 2023;69(10):10.7754. https://doi.org/10.7754/Clin.Lab.2023.230418
  5. Singh A, Chaudhary R, Pandey HC, et al. Identification of iron status of blood donors by using low hemoglobin density and microcytic anemia factor. Asian Journal of Transfusion Science. 2018;12(1):46-50.  https://doi.org/10.4103/ajts.AJTS_30_17
  6. Urrechaga E. Low Hb density (LHD %) in the detection of latent iron deficiency in non-anemic premenopausal women. Journal of Human Nutrition and Food Science. 2016;4(4):1094. https://www.researchgate.net/publication/308166488_Low_Hb_Density_LHD_in_the_Detection_of_Latent_Iron_Deficiency_in_Non-Anemic_Premenopausal_Women
  7. Trtica M, Milenkovic B, Jankovic J, et al. Iron deficiency in nonanaemic COPD patients-Could Low haemoglobin density and Microcytic anaemia factor be usefull? International Journal of Laboratory Hematology. 2023; 45(3):394-402.  https://doi.org/10.1111/ijlh.14029
  8. Dopsaj V, Martinovic J, Dopsaj M. Early detection of iron deficiency in elite athletes: Could microcytic anemia factor (Maf) be useful? International Journal of Laboratory Hematology. 2014;36:37-44.  https://doi.org/10.1111/ijlh.12115
  9. Ng EH, Leung JH, Lau YS, Ma ES. Evaluation of the new red cell parameters on Beckman Coulter DxH800 in distinguishing iron deficiency anaemia from thalassaemia trait. International Journal of Laboratory Hematology. 2015;37(2):199-207.  https://doi.org/10.1111/ijlh.12262
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