Influence of nitric oxide metabolites and markers of apoptosis on restenosis of the reconstruction zone after hybrid interventions

Kalinin R.E.

Pavlov Ryazan State Medical University

ORCID: 0000-0002-0817-9573

Suchkov I.A.

Pavlov Ryazan State Medical University

SPIN RSCI: 6473-8662
Scopus AuthorID: 56001271800
ResearcherID: M-1180-2016
ORCID: 0000-0002-1292-5452

Klimentova E.A.

Ryazan State Medical University

ORCID: 0000-0003-4855-9068

Influence of nitric oxide metabolites and markers of apoptosis on restenosis of the reconstruction zone after hybrid interventions

Authors:

Kalinin R.E., Suchkov I.A., Klimentova E.A.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(1): 14‑21

DOI: 10.17116/kardio20241701114

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To cite this article:

Kalinin RE, Suchkov IA, Klimentova EA. Influence of nitric oxide metabolites and markers of apoptosis on restenosis of the reconstruction zone after hybrid interventions. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(1):14‑21. (In Russ.)
https://doi.org/10.17116/kardio20241701114

Подписка 2025 (Russian Journal of Cardiology and Cardiovascular Surgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To evaluate the markers of apoptosis and nitric oxide metabolites in patients with peripheral artery disease (PAD) after hybrid interventions; to estimate the influence of these indicators on postoperative restenosis.

MATERIAL AND METHODS

The study enrolled 30 patients with PAD stage IIB—III (mean age 68.3±4.2 years) who underwent hybrid procedures. We analyzed the markers of apoptosis (sFas, Bcl-2) and endothelial dysfunction (nitric oxide (NO)) metabolites at various times of perioperative period.

RESULTS

Nine out of 30 patients developed restenosis after 12 [10; 13] months. In the first hours after surgery, patients with restenosis had more obvious decrease in level of Bcl-2 (p=0.002), on the 1^st day — Bcl-2 (p=0.0002) and NO (p=0.002), after a month — NO (p=0.019). After 7 days, Bcl-2 (p<0.01) and NO (p<0.01) significantly increased in patients without restenosis, after 14 days — NO (p<0.01). After 21 days, sFas decreased (p=0.01) in patients without this complication.

CONCLUSION

Hybrid intervention activates the markers of various pathways of apoptosis affecting endothelial dysfunction. Bcl-2≤1.82 ng/ml within the first hours, NO≤240.4 mmol/ml after 14 days and sFas≥0.82 ng/ml after 21 days are associated with higher risk of restenosis.

Keywords:

restenosis

Bcl-2

sFas

nitric oxide metabolites

atherosclerosis

Authors:

Kalinin R.E.

Pavlov Ryazan State Medical University

ORCID: 0000-0002-0817-9573

Suchkov I.A.

Pavlov Ryazan State Medical University

SPIN RSCI: 6473-8662
Scopus AuthorID: 56001271800
ResearcherID: M-1180-2016
ORCID: 0000-0002-1292-5452

Klimentova E.A.

Ryazan State Medical University

ORCID: 0000-0003-4855-9068

Received:

05.01.2023

Accepted:

28.01.2023

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