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Larina V.N.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Oynotkinova O.Sh.

Research Institute of Health Organization and Medical Management;
Central State Medical Academy of the Office of the President of the Russian Federation

Larin V.G.

Pirogov Russian National Research Medical University

Lunev V.I.

Pirogov Russian National Research Medical University

Matskeplishvili S.T.

Lomonosov Moscow State University

Gusarenko S.A.

Branch of the Main Directorate for Servicing the Diplomatic Corps under the Ministry of Foreign Affairs of Russia “Medical Center”

Heart failure with preserved left ventricular ejection fraction: a comprehensive phenotype-based approach to diagnosis and treatment

Authors:

Larina V.N., Oynotkinova O.Sh., Larin V.G., Lunev V.I., Matskeplishvili S.T., Gusarenko S.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2022;15(6): 627‑636

DOI: 10.17116/kardio202215061627

Read: 8531 times

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Table of contents

HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION: A COMPREHENSIVE PHENOTYPE-BASED APPROACH TO DIAGNOSIS AND TREATMENT
HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION: A COMPREHENSIVE PHENOTYPE-BASED APPROACH TO DIAGNOSIS AND TREATMENT

To cite this article:

Larina VN, Oynotkinova OSh, Larin VG, Lunev VI, Matskeplishvili ST, Gusarenko SA. Heart failure with preserved left ventricular ejection fraction: a comprehensive phenotype-based approach to diagnosis and treatment. Russian Journal of Cardiology and Cardiovascular Surgery. 2022;15(6):627‑636. (In Russ.)
https://doi.org/10.17116/kardio202215061627

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article presents modern data on diagnosis and prediction of the course of heart failure with preserved left ventricular ejection fraction (HFpLVEF) in patients with unexplained shortness of breath following physical effort. Applicability of the algorithms for diagnosis of HFpLVEF involving clinical assessment, hemodynamic parameters at rest and under load, natriuretic peptides, as well as index of global left ventricular function is discussed. The authors analyzed phenotype-oriented approach to diagnosis of HFpLVEF, in particular, inflammatory-metabolic and mitochondrial phenotypes characterized by epicardial adipose tissue enlargement, microvascular endothelial dysfunction, increased systolic blood pressure following multiple comorbidities such as obesity, metabolic syndrome, diabetes mellitus and atrial fibrillation. Targeted corrective approaches focused on cardioprotective mitochondrial therapy with Neoton are considered.

Keywords:

heart failure
preserved left ventricular ejection fraction
inflammatory-metabolic phenotype
mitochondria
diagnosis
cardiac protectors
phosphocreatine
Neoton

Authors:

Larina V.N.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Oynotkinova O.Sh.

Research Institute of Health Organization and Medical Management;
Central State Medical Academy of the Office of the President of the Russian Federation

Larin V.G.

Pirogov Russian National Research Medical University

Lunev V.I.

Pirogov Russian National Research Medical University

Matskeplishvili S.T.

Lomonosov Moscow State University

Gusarenko S.A.

Branch of the Main Directorate for Servicing the Diplomatic Corps under the Ministry of Foreign Affairs of Russia “Medical Center”

Received:

12.09.2022

Accepted:

10.10.2022

Close metadata

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