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Mesitskaia D.F.

GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Roszdrava, Moskva

Bykova A.A.

GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Kopylov F.Iu.

Pervyĭ MGMU im. I.M. Sechenova, kafedra profilakticheskoĭ i neotlozhnoĭ kardiologii FPPOV, Moskva

Syrkin A.L.

Sechenov First Moscow State Medical University

The impact of smoking on sensitivity to antiplatelet therapy with clopidogrel

Authors:

Mesitskaia D.F., Bykova A.A., Kopylov F.Iu., Syrkin A.L.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2019;12(6): 516‑521

DOI: 10.17116/kardio201912061516

Views: 2939

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Table of contents

THE IMPACT OF SMOKING ON SENSITIVITY TO ANTIPLATELET THERAPY WITH CLOPIDOGREL
THE IMPACT OF SMOKING ON SENSITIVITY TO ANTIPLATELET THERAPY WITH CLOPIDOGREL

To cite this article:

Mesitskaia DF, Bykova AA, Kopylov FIu, Syrkin AL. The impact of smoking on sensitivity to antiplatelet therapy with clopidogrel. Russian Journal of Cardiology and Cardiovascular Surgery. 2019;12(6):516‑521. (In Russ.)
https://doi.org/10.17116/kardio201912061516

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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Objective — to analyze the impact of smoking on the effectiveness of antiplatelet therapy in patients with cardiovascular diseases. Material and methods. The study included 250 patients aged 60.8±10.0 years who received clopidogrel (70.4% of men and 29.6% of women). Patients were hospitalized in Moscow hospitals for the period from October 2011 to September 2012. Results. We found a significant decrease of platelet aggregation in 7 days after clopidogrel administration in all groups of patients (smokers, non-smokers, and quitters). However, ADP-induced aggregation in 7 days after therapy onset did not show significant effect of smoking on sensitivity to clopidogrel therapy. No significant effect of smoking status on the resistance to clopidogrel therapy was found.

Keywords:

antiplatelet therapy
resistance
smoking
cardiovascular complications

Authors:

Mesitskaia D.F.

GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Roszdrava, Moskva

Bykova A.A.

GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Kopylov F.Iu.

Pervyĭ MGMU im. I.M. Sechenova, kafedra profilakticheskoĭ i neotlozhnoĭ kardiologii FPPOV, Moskva

Syrkin A.L.

Sechenov First Moscow State Medical University

List of references:

  1. Ofitsial’nyj sajt Ministerstva zdravookhraneniya Rossijskoj Federatsii. (In Russ.) www.rosminzdrav.ru/ministry/61/22/stranitsa-979/statisticheskie-i-informatsionnye-materialy/doklady-ob-itogah-deyatelnosti-minzdrava-rossii
  2. Ofitsial’nyj sajt STATISTIKA.ru: Goskomstat, Rosstat i gosudarstvennye sluzhby statistiki RF. (In Russ.) http://statistika.ru/zdr/skolko-v-rossii-kurilshchikov.html
  3. Mozaffarian D, Wilson PW, Kannel WB. Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease. Circulation. 2008;117:3031-3038.
  4. Willi C, Bodenmann P, Ghali WA. Active smoking and the risk of type 2 diabetes: a systematic review and metaanalysis. JAMA. 2007;298:2654-2664.
  5. Svedeniya o smertnosti naseleniya po prichinam smerti po Rossijskoj Federatsii za yanvar’-dekabr’ 2017 goda. (In Russ.) www.gks.ru/free_doc/2017/demo/t3_3.xls
  6. Matetzky S, Fefer P. The genetic basis of platelet responsiveness to clopidogrel. Thromb Haemost. 2011;106:203-210.
  7. Ezzati M, Lopez AD. Estimates of global mortality attributable to smoking in 2000. Lancet. 2003;362:847-852.
  8. Yousef AM, Arafat T, Bulatova NR, et al. Smoking behavior modulates pharmacokinetics of orally administered clopidogrel. J Clin Pharm Ther. 2008;33:439-449.
  9. Gremmel T, Steiner S, Seidinger D. Smoking promoted clopidogrel-mediated platelet inhibition in patients receiving dual antiplatelet therapy. Thrombosis and Haemostasis. 2009;124(5):588-591.
  10. Sibbing D, Bernlochner I, Schulz S. The impact of smoking on the antiplatelet action of clopidogrel in non-ST-elevation myocardial infarction patients: results from the ISAR-REACT 4 platelet substudy. Thrombosis and Haemostasis. 2012;10:2199-2202.
  11. Crimi G, et al. Cigarette smoking reduces platelet reactivity independently of clopidogrel treatment in patients with non-ST elevation acute coronary syndromes. Platelets. 2018;vol 29,№3:309-311. https://doi.org/10.1080/09537104.2017.1394452
  12. Bliden KP, Dichiara J, Lawal L. The association of cigarette smoking with enhanced platelet inhibition by clopidogrel. J Am Coll Cardiol. 2008;52:531-533.
  13. Berger JS, Bhatt DL, Steinhubl SR. Smoking, clopidogrel, and mortality in patients with established cardiovascular disease. Circulation. 2009;120(23):2337-2344.
  14. Karazniewicz M, Danielak D, Glowka F. Genetic and non-genetic factors affecting the response to clopidogrel therapy. Expert Opinion Pharmacother. 2012;13(5):663-683.
  15. Sun Young Choi, Moo Hyun Kim. Comparison of factors affecting platelet reactivity in various platelet function tests. Platelets. 2018;Jul 1;21:213-217. https://doi.org/10.1080/09537104.2018.1499887
  16. Paul A. PARADOX: Smoking influences pharmacokinetics and pharmacodynamics of clopidogrel. Gurbel for Cardiology Today. 2012 December.

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