Aim — to analyze long-term survival in patients with coronary artery disease (CAD) after different methods of myocardial revascularization. Material and methods. There were 352 CAD patients (mean age 57.6±7.7 years) who underwent coronary artery bypass grafting (CABG) (n=183) or percutaneous coronary interventions (PCI) with drug-eluting stent deployment (n=169). Each group was divided into two subgroups: subgroup 1 — lesion of 1—2 coronary arteries (CA), subgroup 2 — lesion of left main CA (LMCA) lesion and/or triple-vessel disease. Charlson comorbidity index (CCI score) was used to assess prognosis of long-term survival. Results. Correlation of CCI Score and survival was estimated by using of Kaplan—Meier curves. Three-year survival was 93.8, 92.7 and 87% in patients with CCI Score 1—2, 3—4, and ≥5, respectively in CABG group. In PCI group those values were 95.3, 91.0 and 88.9%, respectively. Three-year survival was similar in CABG and PCI groups. At the same time, within-group differences were revealed depending on CCI Score. In CABG group CCI Score 1—2 was followed by better survival compared with CCI Score ≥5 (93.8% vs. 87.0%, respectively, p=0.044); in PCI group — 95.3% vs. 88.9%; p=0.038. Conclusion. Charlson comorbidity index may be used as predictor of long-term outcomes after both CABG and PCI.