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Barbarash O.L.

Kemerovskaia oblastnaia klinicheskaia bol'nitsa

Gruzdeva O.V.

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia;
Kemerovo State Medical Academy, Kemerovo, Russia

Krivoshapova K.E.

Research Institute for Complex Issues of Cardiovascular Diseases;
Kemerovo State Medical University of Healthcare Ministry of the Russia, Kemerovo, Russia

Effectiveness and safety of preoperative aspirin therapy in patients undergoing elective coronary artery bypass grafting

Authors:

Barbarash O.L., Gruzdeva O.V., Krivoshapova K.E.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2017;10(6): 9‑15

DOI: 10.17116/kardio20171069-15

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Table of contents

EFFECTIVENESS AND SAFETY OF PREOPERATIVE ASPIRIN THERAPY IN PATIENTS UNDERGOING ELECTIVE CORONARY ARTERY BYPASS GRAFTING
EFFECTIVENESS AND SAFETY OF PREOPERATIVE ASPIRIN THERAPY IN PATIENTS UNDERGOING ELECTIVE CORONARY ARTERY BYPASS GRAFTING

To cite this article:

Barbarash OL, Gruzdeva OV, Krivoshapova KE. Effectiveness and safety of preoperative aspirin therapy in patients undergoing elective coronary artery bypass grafting. Russian Journal of Cardiology and Cardiovascular Surgery. 2017;10(6):9‑15. (In Russ.)
https://doi.org/10.17116/kardio20171069-15

 
 
ЭндоКард
Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Aim — to evaluate the efficacy and safety of preoperative prolonged antiplatelet therapy in patients with coronary artery disease (CAD) undergoing elective coronary artery bypass grafting (CABG). Material and methods. This trial included 168 patients with preoperative antiplatelet therapy intake before CABG. This group initially consisted of patients with higher cardiovascular risk. Control group included 218 patients who underwent CABG with withdrawal of aspirin and heparin administration. Clinical data, surgical interventions and treatment, intra- and postoperative complications and outcomes have been analyzed. Statistical analysis was carried out by using of Statistica 8.0.360.0 software for Windows («StatSoft Inc.», USA), IBM SPSS Statistics version 17.0.0. Differences were significant at p≤0.05. Results. There were no ischemic events in case of prolonged aspirin therapy despite higher preoperative cardiovascular risk in those patients. Intra- and early postoperative myocardial infarction (MI) developed in 2 (1%) patients and 4 (2.4%) patients both groups respectively. 24-hour drainage output was similar in both groups. In aspirin therapy group the frequency of blood transfusions was significantly higher than in the main group (85.1% vs. 15.1%; p=0.0001). Conclusion. Prolonged antiplatelet therapy before CABG is an equally safe alternative to «standard» scheme of preoperative medication. Moreover, it significantly reduces the incidence of perioperative ischemic events.

Keywords:

coronary artery bypass grafting
resternotomy
hemotransfusion

Authors:

Barbarash O.L.

Kemerovskaia oblastnaia klinicheskaia bol'nitsa

Gruzdeva O.V.

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia;
Kemerovo State Medical Academy, Kemerovo, Russia

Krivoshapova K.E.

Research Institute for Complex Issues of Cardiovascular Diseases;
Kemerovo State Medical University of Healthcare Ministry of the Russia, Kemerovo, Russia

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References:

  1. Bokeria LA, Gudkova RG. Diseases and congenital anomalies of the circulatory system. Cardiovascular Surgery. 2015;17 (In Russ.)
  2. Motwani JG, Topol EJ. Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention. Circulation. 1998;97:916-931. https://doi.org/10.1161/01.cir.97.9.916
  3. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 1996;348(9038):1329-1339. https://doi.org/10.1016/s0140-6736(96)09457-3
  4. Fihn SD, Gardin JM, Abrams J, et al. ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease. JACC. 2012;60(24):44-164. https://doi.org/10.1016/j.jacc.2012.07.012
  5. Ferraris VA, Ferraris SP, Lough FC, et al. Preoperative aspirin ingestion increases operative blood loss after coronary artery bypass grafting. Ann Thorac Surg. 1988;45:71-74. https://doi.org/10.1016/s0003-4975(10)62401-0
  6. Rawitscher RE, Jones JW, McCoy TA, et al. A prospective study of aspirin’s effect on red blood cell loss in cardiac surgery. J Cardiovasc Surg. 1991;32:1-7.
  7. Reich DL, Patel GC, Vela-Cantos F, et al. Aspirin does not increase homologous blood requirements in elective coronary bypass surgery. Anesth Analg. 1994;79:4-8. https://doi.org/10.1213/00000539-199407000-00002
  8. Lindblad B, Persson NH, Takolander R, et al. Does low dose acetylsalicylic acid prevent stroke after carotid surgery? A doubleblind, placebo-controlled randomized trial. Stroke. 1993;24:1125-1128. https://doi.org/10.1161/01.str.24.8.1125
  9. Sethi GK, Copeland JG, Goldman S, et al. Implications of preoperative administration of aspirin in patients undergoing coronary artery bypass grafting. Department of veterans Affairs Cooperative Study on Antiplatelet Therapy. J Am Coll Cardiol. 1990;15:15-20. https://doi.org/10.1016/0735-1097(90)90168-o
  10. Morawski W, Sanak M, Cisowski M, et al. Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: role of aspirin and platelet glycoprotein IIIa polymorphism. J Thorac Cardiovasc Surg. 2005;130;791-796. https://doi.org/10.1016/j.jtcvs.2005.02.041
  11. Kallis P, Tooza JA, Talbot S, et al. Preoperative aspirin decreases platelet aggregation and increases post-operative blood loss — a prospective, randomized, placebo controlled, double-blind clinical trial in 100 patients with chronic stable angina. Eur J Cardiothorac Thorac Surg. 1994;8:404-409. https://doi.org/10.1016/1010-7940(94)90081-7
  12. Weightman WM, Gibbs NM, Weidmann CR, et al. The effect of preoperative aspirin-free interval on red blood cell tansfusion requirements in cardiac surgical patients. J Cardiothorac Vasc Anesth. 2002;16:54-58. https://doi.org/10.1053/jcan.2002.29674
  13. Myles PS, Smith J, Knight J, et al. Aspirin and tranexamic acid for coronary artery surgery (ATACAS) trial: rationale and design. Am Heart J. 2008;155:224-230. https://doi.org/10.1016/j.ahj.2007.10.003
  14. Bélisle S, Hardy JF. Hemorrhage and the use of blood products after adult cardiac operations: myths and realities. Ann Thorac Surg. 1996;62:1908-1917. https://doi.org/10.1016/s0003-4975(96)00944-7
  15. Charnaya MA. Pathogenesis of hemostasis disorders in cardiac surgery: Dis... d-ra med. nauk. M. 2007;42. (In Russ.)
  16. Daly DJ, Myles PS, Smith JA, et al. Anticoagulation, bleeding and blood transfusion practices in Australasian cardiac surgical practice. Anaesth Intensive Care. 2007;35:760-768.
  17. Stover EP, Siegel LC, Parks R, et al. Variability in transfusion practice for coronary artery bypass surgery persists despite national consensus guidelines: a 24-institution study. Anesthesiology. 1998;88:327-333. https://doi.org/10.1097/00000542-199802000-00009
  18. Covin R, O’Brien M, Grunwald G, et al. Factors affecting transfusion of fresh frozen plasma, platelets, and red blood cells during elective coronary artery bypass graft surgery. Arch Pathol Lab Med. 2003;127:415-423.
  19. Despotis GJ, Filos KS, Zoys TN, et al. Factors associated with excessive postoperative blood loss and hemostatic transfusion requirements: a multivariate analysis in cardiac surgery patients. Anesth Analg. 1996;82:13-21. https://doi.org/10.1097/00000539-199601000-00004
  20. Singh A, Doris J, Ferraris, et al. The cost of excessive postoperative blood transfusion after cardiac operations. Surg Forum. 1996;47:652-654.
  21. Bucerius J, Gummert JF, Borger MA, et al. Stroke after cardiac surgery: a risk factor analysis of 16,184 consecutive adult patients. Ann Thorac Surg. 2003;75(2):472-478. https://doi.org/10.1016/s0003-4975(02)04370-9
  22. Dacey LJ, Munoz JJ, Johnson ER, et al. Effect of preoperative aspirin use on mortality in coronary artery bypass grafting patients. Ann Thorac Surg. 2000;70:1986-1990. https://doi.org/10.1016/s0003-4975(00)02133-0
  23. Mangano DT. Aspirin and mortality from coronary bypass surgery. N Eng J Med. 2002;347:1309-1317. https://doi.org/10.1056/nejmoa020798
  24. Tuman KJ, McCarthy RJ, O’Connor CJ, et al. Aspirin does not increase allogenic blood transfusion in reoperative coronary artery surgery. Anesth Analg. 1996;83:1178-1184. https://doi.org/10.1097/00000539-199612000-00008
  25. Shim JK, Choi YS, Oh YJ, et al. Effects of preoperative aspirin and clopidogrel therapy on perioperative blood loss and blood transfusion requirements in patients undergoing off-pump coronary artery bypass graft surgery. J Thorac Cardiovasc Surg. 2007;134:59-64. https://doi.org/10.1016/j.jtcvs.2007.03.013
  26. Mehta RH, Sheng S, O’Brien SM, et al. Reoperation for bleeding in patients undergoing coronary artery bypass surgery incidence, risk factors, time trends, and outcomes. Circ Cardiovasc Qual Outcomes. 2009;2:583-590. https://doi.org/10.1161/circoutcomes.109.858811
  27. Longhui Cao, Nilas Young, Hong Liu, et al. Preoperative aspirin use and outcomes in cardiac surgery patients. Ann Surg. 2012;255:399-404. https://doi.org/10.1097/sla.0b013e318234313b
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