It was analyzed the immediate results of repeated surgical interventions in patients who previously underwent surgery for valve disease with cardiopulmonary bypass. During the period from 2003 to 2012 re-interventions on heart valve were made in 90 patients. It amounted 6.8% of the total number of surgical interventions for heart disease. Patients' age ranged from 18 to 70 years (mean 54.6±9.5 years). The indications for reoperation included defect recurrence of previously reconstructed valve or defect of other heart valves in 43 (47.8%) patients, dysfunction of mechanical prostheses in 43 (47.8%) patients, dysfunction of bioprostheses due to degenerative involution in 4 (4.4%) observations. Isolated repeated mitral or aortic valve replacement was performed in 36 (40%) patients, paraprosthetic fistula suturing with De Vega plasty of tricuspid valve - in 2 (2.2%) cases. Repeated interventions on the mitral and aortic valves were performed in 14 (15.6%) patients. Mortality rate was 2.2% (2 patients). It was demonstrated good results of mortality and number of postoperative complications.