Mexidol influence on the parameters of infrared spectrometry of blood lipid complex in case of acute coronary syndrome

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It was analyzed the mexidol influence on phospholipid metabolism in acute coronary syndrome (ACS). The study included 70 patients. Intravenous mexidol infusions were included in the complex therapy in 30 cases. Conventional clinical and laboratory data, as well as the absorption of lipid phospholipid complexes in the infrared spectrum of blood serum were evaluated. The study established a mechanism of phospholipids autoregulation as a wave-like fluctuations of their concentration in the blood serum with early increasing (compared with healthy) in the first hours and days of development of ACS. It was observed the maximum rise by the 4th day and a moderate decline by the 10 day of observation reflecting the degree of adaptation systems stress. Regardless on the clinical form of ACS mexidol application eliminates oscillatory nature of the phospholipids dynamics. It is stabilizing their rise at a level sufficient to ensure the power and plastic needs of the organism and myocardium that improves the results of combined treatment.

Keywords:

acute coronary syndrome

homeostasis

phospholipids

mexidol

infrared spectrometry

Authors:

Shpak L.V.

Tverskaia gosudarstvennaia meditsinskaia akademiia, kafedra vnutrennikh bolezneĭ FPDO i kafedra khimii

Zubareva G.M.

Tverskaia gosudarstvennaia meditsinskaia akademiia, kafedra vnutrennikh bolezneĭ FPDO i kafedra khimii

Lebedeva S.N.

Tverskaia gosudarstvennaia meditsinskaia akademiia, kafedra vnutrennikh bolezneĭ FPDO i kafedra khimii

List of references:

Belyakin S.А., Igonin V.А., SHames А.B., Proskurin V.M. Ostryj koronarnyj sindrom: sovremennye podkhody k diagnostike i lecheniyu [Acute coronary syndrome: current approaches to diagnosis and treatment]. Voen-med zhurn 2009; 3: 24-29. (in Russian)
Belousov YU.B., Zyryanov S.K., Syrov А.V. Sravnitel'naya farmakoehkonomicheskaya otsenka ehnoksaparina i nefraktsionnogo geparina pri ostrom koronarnom sindrome bez pod"ema segmenta ST [Comparative pharmacoeconomic evaluation of enoxaparin and unfractionated heparin in acute coronary syndrome without ST segment elevation]. Ros kardiol zhurn 2010; 2: 59-66. (in Russian)
Vereshhagina V.S. Issledovanie nekotorykh aspektov mekhanizma protivoaritmicheskogo dejstviya dimefosfana i meksidola [A study of certain aspects of the antiarrhythmic action of dimefosfan and mexidol]: Аvtoref. dis. ... kand. med. nauk. Kupavna 2002. (in Russian)
Voronina T.А. Otechestvennyj preparat novogo pokoleniya meksidol, osnovnye ehffekty, mekhanizm dejstviya, primenenie [New domestic drug meksidol, the main effects, mechanism of action, the use]. M 2003. (in Russian)
Voronina T.А. Osnovnye nejropsikhotropnye ehffekty i mekhanizm dejstviya [Basic neuropsychotropic effects and mechanism of action.]. Farmateka 2009; 6: 1-4. (in Russian)
Ganelina I.E., Rodionova V.I., Katyukhin L.N., Teplyakov D.V. Dannye koronarografii i reologicheskikh svojstv ehritrotsitov pri ostrom koronarnom sindrome bez pod"ema segmenta ST [Coronary angiography data and rheological properties of red blood cells in acute coronary syndrome without ST segment elevation]. Kardiologiya 2011; 4: 4-9. (in Russian)
Gar'kin G.G. Sravnitel'naya otsenka kardioprotektornogo ehffekta obzidana, meksidola, ehmoksipina, dimefosfana I preduktala pri ishemii miokarda [Comparative evaluation of the cardioprotective effect of obsidan, mexidol, emoxipine, dimefosfan and preductal in myocardial ischemia]: Аvtoref. dis. … kand. med. nauk. Saransk 2001. (in Russian)
Dolzhenko M.N. Ostryj koronarnyj sindrom: lechenie diabeticheskojdislipidemimii metodom ehterosorbtsii [Acute coronary syndrome: treatment of diabetic dyslipidemia by enterosorption]. Meditsina neotlozhnykh sostoyanij 2007; 3: 63-64. (in Russian)
Kargapolov А.V., Zubareva G.M. Patent RF №2164685 ot 27.03.99. (in Russian)
Lutskij M.А. Аnaliz ehffektivnosti meksidola v kompleksnom lechenii bol'nykh s ishemicheskim insul'tom [Analysis of the mexidol effectiveness in complex treatment of patients with ischemic stroke]. ZHurn nevrol i psikhiatr 2010; 4: 57-59. (in Russian)
Lutskij M.А., Nazarenko E.А., Razinkin K.А. Primenenie otechestvennogo antioksidanta - preparata Meksidol v kompleksnom lechenii ishemicheskogo insul'ta [Application of domestic anti-oxidant - Meksidol drug in treatment of ischemic stroke.]. Ros med zhurn2008; 12: 1661. (in Russian)
Makarova M.YU. Otsenka kardioprotektornogo dejstviya nekotorykh preparatov s antioksidantnoj aktivnost'yu pri sochetaniyakh ehksperimental'nogo diabeta s fizicheskoj na-gruzkoj [Rating of cardioprotective effects of some drugs with antioxidant activity in case of combined experimental diabetes with exercise]. EHksper i klin farmakol 2003; 1: 40-45. (in Russian)
Mari R., Grenner D., Mejes P., Roduehll V. Biokhimiya cheloveka [human biochemistry].V 2-kh t. T. 1. M: Mir 2004; 414. (in Russian)
Mikhin V.P., Mikhajlova T.YU., KHarchenko А.V. i dr. EHffektivnost' prolongirovannykh nitratov u bol'nykhstabil'noj stenokardiej napryazheniya na fone sochetannogo primeneniya meksikora [Effectiveness of prolonged nitrates in patients with stable exertional angina on background of combined application of mexicor]. Klinicheskie issledovaniya lekarstvennykhsredstv v Rossii 2003; 2: 23-26. (in Russian)
Mikhin V.P., Pokrovskij N.V., Gureev V.V. i dr. EHffektivnost' otechestvennogo miokardial'nogo tsitoprotektora I ego farmakodinamika pri ostroj ishemii miokarda: klinicheskie rezul'taty i ehksperimental'nye modeli [Effectiveness of domestic myocardial cytoprotector and its pharmacodynamics in acute myocardial ischemia: clinical results and experimental models]. Ros kardiol zhurn 2011; 2: 37-42. (in Russian)
Nechaeva G.I., Korennova O.YU., Bulakhova E.YU. Ispol'zovanie preparata Meksidol dlya optimizatsii lecheniya arterial'noj gipertenzii u lits molodogo vozrasta [Meksidol drug use to optimize the treatment of hypertension in young adults]. Med vestn 2008; 6-7: 433-434. (in Russian)
Nikol'skaya I.N., KHromova O.M., Irkhina I.S. i dr. Sravnitel'naya otsenka klinicheskoj ehffektivnosti i bezopasnosti preparata meksidol u bol'nykh s OKS pri vklyuchenii vstandartnuyu skhemu terapii [Comparative evaluation of clinical efficacy and safety of meksidol in ACS patients with inclusion in the standard therapeutic regimen]. ZHurn nevrol i psikhiatr 2013; 3: 37-42. (in Russian)
Radushkevich V.L. Klinicheskaya otsenka preparata Meksidol pri lechenii tyazheloj cherepno-mozgovoj travmy na ehtapakh meditsinskoj pomoshhi [Clinical evaluation of the Meksidol in the treatment of severe traumatic brain injury during medical care]. Neotlozhnaya meditsina 2012; 1: 3-6. (in Russian)
Sel'e G. Ocherki adaptatsionnogo sindroma [Essays of adaptation syndrome]. M: Meditsina 1960; 254. (in Russian)
Sidorenko G.I., Komisarova S.M., Zolotukhina S.F., Petrovskaya M.E. Primenenie ehtilmetilgidroksipiridinasuktsinata v lechenii bol'nykh s serdechnoj nedostatochnost'yu [etilmetilgidroksipiridina application in the treatment of patients with heart failure]. Kar-diologiya 2011; 6: 44-48. (in Russian)
Syrov А.V., Zyryanov S.K., Belousov YU.B. Optimizatsiya antikoagulyantnoj terapii u bol'nykh OKS bez pod"ema segmenta ST na osnovanii farmakoehkonomicheskogo analiza [Optimization of anticoagulation therapy in patients with ACS without ST elevation ST on the basis of pharmacoeconomic analysis]. Ros med zhurn 2010; 10: 617-622. (in Russian)
CHerfanova ZH.YU. Otsenka ehffektivnosti primeneniya meksidola v sochetanii s tromboliticheskoj terapiej u bol'nykh s ishemicheskim insul'tom [Evaluating the effectiveness of mexidol in combination with thrombolytic therapy in patients with ischemic stroke]. ZHurn nevrol i psikhiatr 2012; 4: 49-52. (in Russian)
SHpak L.V., Belova N.O. Perspektivnost' primeneniya meksidola v klinicheskoj praktike [Mexidol prospects of application in clinical practice]. Ezhegodnyj sbornik nauchno-prakticheskikh rabot "Obshhie voprosy meditsiny". Tver': Faktor 2010; 131-134. (in Russian)
Fichtlscherer S., Breuer S., Zeiher A.M. Prognostic Value of Systemic Endothelial Dysfunction in Patients With Acute Coronary Syndromes. Further Evidence for the Existence of the "Vulnerable" Patient. Circulation 2004; 110: 1926-1932.
Zweier J.L., Talukder M.A. The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res 2006; 70: 2: 181-190.

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