138 male patients with stable coronary heart disease (CHD) undergoing planned coronary artery bypass grafting (CABG) were investigated. All patients underwent direct myocardial revascularization under artificial circulation (AC). 61 patients (44.2%) with multifocal atherosclerosis formed group 77 patients (55.8%) with isolated CHD - group 2. Level of inflammatory markers was estimated before CABG and on the 10-th day of postoperative period. It is shown that CABG under AC is accompanied by activation of inflammatory processes which are more severe in patients with systemic atherosclerosis. Preoperative level of C-reactive protein, tumor necrosis factor- α and interleukin-10 can serve as a significant marker of cardiovascular complications after CABG in patients with systemic atherosclerotic vascular affection. It is ascertained that high level of C-reactive protein preserving till the 10-th day after operation can indicate the possibility of angina relapse in 1 month after CABG.