Relationship between acute inflammatory response and oxidative stress in patients with acquired heart diseases after their surgical correction

Nepomniashchikh V.A.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

Lomivorotov V.V.

E.N.Meshalkin National Medical Research Center under the Ministry of Health of the Russia, Novosibirsk, 630055, Russia

ORCID: 0000-0001-8591-6461

Lomivorotov V.N.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

Deriagin M.N.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

Fominskiĭ E.V.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

Novikov M.A.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

Relationship between acute inflammatory response and oxidative stress in patients with acquired heart diseases after their surgical correction

Authors:

Nepomniashchikh V.A., Lomivorotov V.V., Lomivorotov V.N., Deriagin M.N., Fominskiĭ E.V., Novikov M.A.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(6): 77‑80

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To cite this article:

Nepomniashchikh VA, Lomivorotov VV, Lomivorotov VN, Deriagin MN, Fominskiĭ EV, Novikov MA. Relationship between acute inflammatory response and oxidative stress in patients with acquired heart diseases after their surgical correction. Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(6):77‑80. (In Russ.)

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Relationship between acute phase of inflammatory response (APIR) and oxidative stress (OS) was studied in patients with acquired heart diseases. 58 patients with acquired heart diseases were investigated before and after operations on open heart. Intensity of APIR was evaluated according to concentrations of C-reactive protein, α1-antitrypsin, α2-macroglobulin and albumin; OS was studied according to indices of malonic aldehyde, coupled triens, ceruloplasmin and plasma catalase. It is shown that cardiosurgical intervention leads to marked APIR and OS on first postoperative day with further reduction of their intensity on 3-4 and 10-12 days after operation. The highest level of APIR corresponded with maximum intensity of OS. Direct correlations between acute phase proteins and lipid peroxidation metabolites were estimated. It is drawn a conclusion that APIR and OS are mutually potentiating and straightly depend on duration of perfusion and myocardial ischemia.

Keywords:

acute inflammatory response

oxidative stress

lipid peroxidation

acquired heart diseases

artificial circulation.

Authors:

Nepomniashchikh V.A.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

Lomivorotov V.V.

E.N.Meshalkin National Medical Research Center under the Ministry of Health of the Russia, Novosibirsk, 630055, Russia

ORCID: 0000-0001-8591-6461

Lomivorotov V.N.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

Deriagin M.N.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

Fominskiĭ E.V.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

Novikov M.A.

FGBU Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdrava Rossii

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