Quality of anticoagulant therapy with warfarin in patients with heart valve prostheses

Zhuravleva I.Iu.; Gorbunova E.V.; Rutkovskaia N.V.; Burkova T.V.; Odarenko Iu.N.; Kokorin S.G.; Savost'ianova Iu.Iu.

doi:https://doi.org/

Zhuravleva I.Iu.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Gorbunova E.V.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ Sibirskogo otdeleniia Rossiĭskoĭ akademii meditsinskikh nauk, Kemerovo

Rutkovskaia N.V.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Burkova T.V.

NII kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Odarenko Iu.N.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Kokorin S.G.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Savost'ianova Iu.Iu.

NII kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Quality of anticoagulant therapy with warfarin in patients with heart valve prostheses

Authors:

Zhuravleva I.Iu., Gorbunova E.V., Rutkovskaia N.V., Burkova T.V., Odarenko Iu.N., Kokorin S.G., Savost'ianova Iu.Iu.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(3): 60‑65

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To cite this article:

Zhuravleva IIu, Gorbunova EV, Rutkovskaia NV, Burkova TV, Odarenko IuN, Kokorin SG, Savost'ianova IuIu. Quality of anticoagulant therapy with warfarin in patients with heart valve prostheses. Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(3):60‑65. (In Russ.)

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

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Abstract:

Efficacy of anticoagulant therapy (ACT) and risk for complications related to warfarin were studied in patients with replaced heart valves. Results of outpatient control investigations were analyzed in 313 patients with mechanic (189 patients) and biologic (124 patients) heart valve prostheses receiving ACT. Low efficacy of ACT and inadequate control of international normalized ratio (INR) were revealed in both groups of patients. Relationship between frequency of INR control and efficacy of ACT was estimated. Among patients controlling INR not less than 1 time per month half of them were in hypocoagulation range and frequency of "huge" hemorrhages among them was 2 times lower compared with patients rarely controlling INR. Frequency of embolic complications depended both on type of prosthesis and efficacy of ACT and didn't have any relationship with INR control regimen. It is drawn a conclusion that the main problem of ACT in patients with heart valve prostheses are inadequate doses of warfarin and irregular control of INR. Risk of embolic complications in patients with mechanic prostheses is significantly higher that risk for "huge" hemorrhages. Pharmacogenetic approach to adjustment of warfarin dosage and widening of indications for application of bioprostheses in patients with predictable problems of ACT are recommended for improvement of clinical situation.

Keywords:

heart valve replacement

anticoagulant therapy

warfarin

complications

Authors:

Zhuravleva I.Iu.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Gorbunova E.V.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ Sibirskogo otdeleniia Rossiĭskoĭ akademii meditsinskikh nauk, Kemerovo

Rutkovskaia N.V.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Burkova T.V.

NII kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Odarenko Iu.N.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Kokorin S.G.

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Savost'ianova Iu.Iu.

NII kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

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References:

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