Clinical and pathological aspects of continuous xenon anesthesia in cardiac surgery

Shishneva E.V.; Podoksenov Yu.K.; Emel'ianova T.V.; Shipulin V.M.; Vaizov V.Kh.

doi:https://doi.org/

Shishneva E.V.

NII kardiologii SO RAMN, Tomsk

Podoksenov Yu.K.

Tomsk National Research Medical Center of RAS «Cardiology Research Institute», Tomsk, Russia;
Siberian State Medical University of Ministry of Health of the Russia, Tomsk, Russia

Emel'ianova T.V.

NII kardiologii SO RAMN, Tomsk

Shipulin V.M.

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia;
Siberian State Medical University, Tomsk, Russia

Vaizov V.Kh.

NII kardiologii SO RAMN, Tomsk

Clinical and pathological aspects of continuous xenon anesthesia in cardiac surgery

Authors:

Shishneva E.V., Podoksenov Yu.K., Emel'ianova T.V., Shipulin V.M., Vaizov V.Kh.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(1): 78‑83

Read: 1018 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Shishneva EV, Podoksenov YuK, Emel'ianova TV, Shipulin VM, Vaizov VKh. Clinical and pathological aspects of continuous xenon anesthesia in cardiac surgery. Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(1):78‑83. (In Russ.)

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Perioperative management of patients with valvular heart disease. Clinical guidelines of the All-Russian Public Organization “Federation of Anesthesiologists and Reanimatologists” (2nd revision, part 1). Russian Journal of Anesthesiology and Reanimatology. 2024;(6):6-22

Comparison of prognostic scales of myasthenic crisis after thymectomy in patients with myasthenia gravis. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):63-69

History of anti-embolic protection in cardiac surgery. Pirogov Russian Journal of Surgery. 2024;(12-2):139-149

Perioperative management of patients with concomitant heart valve disease (2nd revision). Clinical guidelines of the All-Russian Public Organization “Federation of Anesthesiologists and Reanimatologists” (Part 2). Russian Journal of Anesthesiology and Reanimatology. 2025;(1):8-20

Consciousness, sleep, anesthesia. What are we thinking about? Analytical review. Part II. General anesthesia: main concepts, mechanisms and neurophysiological correlates. Russian Journal of Anesthesiology and Reanimatology. 2025;(1):92-100

On the issue of choosing anesthesia methods: a comparison of general medicine and clinical dentistry. Stomatology. 2025;(1):76-80

Chronic postoperative pain in cardiac surgery: analysis of quantitative sensory testing and pain history data. Russian Journal of Pain. 2025;(1):16-23

Cognitive impairment after major surgical operations. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):74-80

Influence of menstrual phase on the effect of rocuronium bromide. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):14-18

Dynamics of endotracheal tube cuff pressure during general anesthesia with xenon in children in outpatient dental practice. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):50-54

Abstract:

Method of continuous xenon anesthesia allowing not to switch for other types of anesthesia was studied during cardiosurgical operations under artificial circulation. 30 patients aged 42-68 years undergoing coronary bypass grafting were included in the study. Central hemodynamics, cerebral blood flow, indices of acid-base balance, oxygen extraction index, cerebral saturation,concentrations of cortisol, neurospecific protein S-100Β and neurospecific enolase were investigated during the operation and postoperative period. It is shown that continuous xenon anesthesia decreases consuption of this gas, is safe, doesn't cause any side effects concerning central hemodynamics, metabolism, and cerebral blood flow, and can be used efficiently in cardiac surgery.

Keywords:

cardiac surgery

artificial circulation

anesthesia

xenon

Authors:

Shishneva E.V.

NII kardiologii SO RAMN, Tomsk

Podoksenov Yu.K.

Tomsk National Research Medical Center of RAS «Cardiology Research Institute», Tomsk, Russia;
Siberian State Medical University of Ministry of Health of the Russia, Tomsk, Russia

Emel'ianova T.V.

NII kardiologii SO RAMN, Tomsk

Shipulin V.M.

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia;
Siberian State Medical University, Tomsk, Russia

Vaizov V.Kh.

NII kardiologii SO RAMN, Tomsk

Close metadata

References:

Burov N.E., Potapov V.N., Makeev G.N. Ksenon v anestezii. M: Pul's 2000; 356.
Godin A.V., Titov V.A., Stamov V.I. i dr. Nash pervyi opyt primeneniya ksenona v anesteziologicheskoi praktike. Anest i reanimatol 1999; 5: 56-59.
Gorizontov P.D. Stress i reaktsiya organov krovetvoreniya. Pat fiziol 1974; 2: 3.
Gologorskii V.A., Grinenko T.F., Makarova L.D. O probleme adekvatnosti obshchei anestezii. Anest i reanimatol 1988; 2: 3-6.
Kozlov I.A., Stepanova O.V., Voronin S.V. Tsentral'naya gemodinamika, gazoobmen i kislorodtransportnaya funktsiya krovi pri kombinirovannoi anestezii s ispol'zovaniem ksenona vo vremya operatsii s iskusstvennym krovoobrashcheniem. Anest i reanimatol 2006; 5: 20-24.
Kulinskii V.I., Ol'khovskii I.A. Dve adaptatsionnye strategii v neblagopriyatnykh usloviyakh - rezistentnaya i tolerantnaya. Rol' gormonov i retseptorov. Uspekhi sovrem biol 1996; 5-6: 697-713.
Ostapchenko D.A. Sravnitel'naya otsenka pokazatelei tsentral'noi gemodinamiki pri narkoze zakis'yu azota i ksenonom v usloviyakh zakrytogo kontura: Avtoref. dis. … kand. med. nauk. M 1993; 167.
Pavlova R.A., Ovchinnikov D.N., Beregovaya N.V. i dr. Vozmozhnosti lecheniya ksenonom v ostruyu fazu infarkta miokarda. Ksenon i inertnye gazy v otechestvennoi meditsine. M 2010: 176-189.
Postnov V.G., Karas'kov A.M., Lomivorotov V.N., Zel'man V.L. Nevrologicheskaya i neiropsikhologicheskaya fenomenologiya v kardiokhirurgii. Cib med zhurn 2009; 3: 3-18.
Rudenko M.I., Pas'ko V.G., Taubaev B.M. i dr. Opyt primeneniya ksenonovoi anestezii v Glavnom voennom klinicheskom gospitale im. akad. N.N. Burdenko. Klin anest reanimatol 2006; 3: 58-64.
Sal'nikov P.S., Burov N.E. Kontrol' adekvatnosti monoanestezii ksenonom po dannym bispektral'nogo indeksa. Vestn intensivnoi ter 2002; 4: 72-76.
Stepanova O.V., Voronin C.V., Il'nitskii V.V. i dr. Ksenonovaya anesteziya pri operatsiyakh revaskulyarizatsii miokarda i transplantatsii serdtsa. Transplantologiya 2006; 3: 54-59.
Stepanova O.V. Ksenonovaya anesteziya pri operatsiyakh s iskusstvennym krovoobrashcheniem: Avtoref. dis. … kand. med. nauk. M 2008; 124.
Khlusov I.A., Naumov S.A., Vovk S.M., Kornetov N.A. Vliyanie ksenona na kletki i retseptory. Vestn RAMN 2003; 9: 32-37.
Arrowsmith J.E., Grocott H.P., Reves J.G., Newman M.F. Central nervous system complications of cardiac surgery. Br J Anaesthes 2000; 84: 3: 378-393.
Baumert J.H., Falter F., Eletr D. Xenon anaesthesia may preserve cardiovascular function in patients with heart failure. Acta Anaesthesiol Scand 2005; 49: 743-749.
Boomsma E., Ruprent J. Hemodinamic and neurogumoral effects of xenon anaesthesia. Anaesthesia 1990; 45: 273-278.
Koerner I.P., Brambrink A.M. Brain protection by anesthetic agents. Curr Opin Anaesthesiol 2006; 19: 481-486.
Lachmann B., Armbruster S. Safety and efficacy of xenon in routin use as inhalation anaestetic. Lancet 1990; 335: 8703: 1413-1415.
Lewelt W., Stewart L., Williams C.L. Cerebral and systematic effects of xenon anesthesia. Appl Cardiopulmon Pathophysiol 1998; 7: 161-165.
Lokwood G.G., Franks N.P., Downie N.A. et al. Feasibility and Safety of Delivering Xenon to Patients Undergoing Coronary Artery Bypass Graft Surgery While on Cardiopulmonary Bypass: Phase I Study Clinical Investigations. Anesthesiology 2006; 104: 458-465.
Luttropp H.H., Romner B., Perhag L. et al. Left ventricular performance and cerebral haemodynamics during xenon anaesthesia. A transoesophageal echocardiography and transcranial Doppler sonography study. Anaestesia 1993; 48: 1045-1049.
Ma D., Hossain M., Chow A. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol 2005; 58: 182-193.
Rajakumaraswamy N., Ma D., Hossain M. et al. Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Neurosci Lett 2006; 409: 128-133.
Stephan H. Cerebral effects of cardiopulmonary bypass techniques. Curr Opinion Anaesth 1996; 9: 65-70.