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Gilyarevsky S.R.

Russian Gerontology Research Clinical Center

Karpov Yu.A.

National Medical Research Center for Cardiology

Luchnikova E.A.

Sciencefiles LLC

Lantsova E.V.

Sciencefiles LLC

Efficacy and tolerability of azilsartan combined with amlodipine and amlodipine monotherapy and combinations of amlodipine with other angiotensin II receptor blockers

Authors:

Gilyarevsky S.R., Karpov Yu.A., Luchnikova E.A., Lantsova E.V.

More about the authors

Journal: Russian Cardiology Bulletin. 2024;19(4‑2): 161‑171

DOI: 10.17116/Cardiobulletin202419042161

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Table of contents

EFFICACY AND TOLERABILITY OF AZILSARTAN COMBINED WITH AMLODIPINE AND AMLODIPINE MONOTHERAPY AND COMBINATIONS OF AMLODIPINE WITH OTHER ANGIOTENSIN II RECEPTOR BLOCKERS
EFFICACY AND TOLERABILITY OF AZILSARTAN COMBINED WITH AMLODIPINE AND AMLODIPINE MONOTHERAPY AND COMBINATIONS OF AMLODIPINE WITH OTHER ANGIOTENSIN II RECEPTOR BLOCKERS

To cite this article:

Gilyarevsky SR, Karpov YuA, Luchnikova EA, Lantsova EV. Efficacy and tolerability of azilsartan combined with amlodipine and amlodipine monotherapy and combinations of amlodipine with other angiotensin II receptor blockers. Russian Cardiology Bulletin. 2024;19(4‑2):161‑171. (In Russ.)
https://doi.org/10.17116/Cardiobulletin202419042161

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the efficacy and safety of combining various angiotensin II receptor blockers with amlodipine compared with amlodipine alone, as well as intake of azilsartan 20—80 mg daily and amlodipine 5—10 mg daily compared to other angiotensin II receptor blockers combined with amlodipine in patients with hypertension.

MATERIAL AND METHODS

The review enrolled 22 clinical trials (21 RCTs and 1 observational study) and 9.708 patients. Among 21 RCTs, 19 studies were blinded and 2 RCTs were open-label.

RESULTS

We found more significant SBP decrease in case of combination of azilsartan with amlodipine compared to amlodipine alone (5 or 10 mg daily). Such advantages of combined antihypertensive therapy with azilsartan and amlodipine were more pronounced compared to combination of other ARBs with amlodipine. Moreover, these advantages of azilsartan combined with amlodipine were significantly clearer compared to valsartan or losartan.

CONCLUSION

We found higher antihypertensive efficacy of azilsartan combined with amlodipine in comparison with combination of other ARBs and amlodipine monotherapy. Despite higher antihypertensive efficacy of azilsartan combined with amlodipine, safety of this therapy did not differ from combination of other ARBs with amlodipine or amlodipine monotherapy.

Keywords:

arterial hypertension
systolic blood pressure
angiotensin II receptor blockers
azilsartan
network meta-analysis

Authors:

Gilyarevsky S.R.

Russian Gerontology Research Clinical Center

Karpov Yu.A.

National Medical Research Center for Cardiology

Luchnikova E.A.

Sciencefiles LLC

Lantsova E.V.

Sciencefiles LLC

Received:

05.11.2024

Accepted:

11.11.2024

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