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Mangileva T.A.

Vernadsky Crimean Federal University

Kazantseva O.A.

Vernadsky Crimean Federal University;
Semashko Republican Clinical Hospital

Dranenko N.Y.

Vernadsky Crimean Federal University;
Semashko Republican Clinical Hospital

Sadovoi V.I.

Semashko Republican Clinical Hospital

Lischuk A.N.

Vishnevsky National Medical Research Center of High Medical Technologies

Inflammation and thrombosis in post-pericardiotomy syndrome

Authors:

Mangileva T.A., Kazantseva O.A., Dranenko N.Y., Sadovoi V.I., Lischuk A.N.

More about the authors

Journal: Russian Cardiology Bulletin. 2023;18(3): 23‑28

DOI: 10.17116/Cardiobulletin20231803123

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INFLAMMATION AND THROMBOSIS IN POST-PERICARDIOTOMY SYNDROME
INFLAMMATION AND THROMBOSIS IN POST-PERICARDIOTOMY SYNDROME

To cite this article:

Mangileva TA, Kazantseva OA, Dranenko NY, Sadovoi VI, Lischuk AN. Inflammation and thrombosis in post-pericardiotomy syndrome. Russian Cardiology Bulletin. 2023;18(3):23‑28. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20231803123

Подписка 2025-2 (Russian Cardiology Bulletin)
 
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Post-pericardiotomy syndrome (PPS) follows open cardiac surgery. This inflammatory process is accompanied by symptoms of pericarditis and/or pleuritis. Anti-inflammatory drugs are the main therapy in these patients. The theory of correlation between inflammation and clotting becomes widespread. Effectiveness of their complex treatment for infectious (new coronavirus infection) and non-infectious (coronary artery disease) diseases is being actively studied. Inflammation, previous surgery, cardiopulmonary bypass, and features of postoperative management can affect hemostasis system in patients with PPS. In addition, various medications for treatment of inflammation reduce or increase the risk of thrombosis. Combined administration of anti-inflammatory and antithrombotic therapy should increase the effectiveness of PPS treatment. Such therapy is really carried out, since the majority of cardiac surgical patients receive antiplatelet agents and/or anticoagulants in postoperative period to treat the underlying disease and prevent its complications. The problem of choosing the optimal combination of agents affecting inflammation and risk of thrombosis is very important.

Keywords:

post-pericardiotomy syndrome
inflammation
clotting

Authors:

Mangileva T.A.

Vernadsky Crimean Federal University

Kazantseva O.A.

Vernadsky Crimean Federal University;
Semashko Republican Clinical Hospital

Dranenko N.Y.

Vernadsky Crimean Federal University;
Semashko Republican Clinical Hospital

Sadovoi V.I.

Semashko Republican Clinical Hospital

Lischuk A.N.

Vishnevsky National Medical Research Center of High Medical Technologies

Received:

15.02.2023

Accepted:

14.03.2023

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