Background. The evolution of stenting technology and new types of stents have improved the results of left main stenting. However, current recommendations are based on the results of the first-generation drug eluting stents (DES) implementation. Objective. To evaluate the long-term results of unprotected left main coronary artery stenting withdifferentcoronary stents types and generations. Materials and methods. The study included 282 patients with left main stenoses. Depending on the type of implantable stents, patients were divided into groups I (1st generation DES, n=100), II (2nd generation DES with insoluble polymer coating, n=101) and III (3rd generation DES with a bioresorbable polymer coating, n=81). Patients in groups I and II received double antiplatelet therapy for 12 months, patients in group III — for 4 months. The duration of follow-up was 34.6 months. Results. The frequency of adverse cardiovascular events (death, myocardial infarction, acute cerebrovascular accident) in 3 years after stenting was higher in group I (29, 9.9 and 4.9%, p<0.0001 in groups I, II and III respectively). In group I, there was a higher frequency of repeated revascularization (27, 11.9 and 7.4, p<0.0001) and repeated revascularization of the target lesion (8, 1 and 0%, p<0.0001). The incidence of stent thrombosis was comparable between groups. The incidence of thrombosis of the 1st generation sirolimus-coated stent was significantly higher compared to the 2nd and 3d generationeverolimus-coated DES. Conclusion. The use of the 2nd and 3d generation DES in patients with left main lesion shows a lower incidence of repeat revascularization. The use of stents with a bioresorbable polymeric coating possibly can lead to reduce of the duration of dual antiplatelet therapy to 4 months with equivalent safety.