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Doroshchuk N.A.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Doroshchuk A.D.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Vitsenya M.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Gavryushina S.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Oschepkova E.V.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

Ageev F.T.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Postnov A.Yu.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Chazova I.E.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

Effect of chemotherapy on the length of telomeres in patients with breast cancer suffering from arterial hypertension

Authors:

Doroshchuk N.A., Doroshchuk A.D., Vitsenya M.V., Gavryushina S.V., Oschepkova E.V., Ageev F.T., Postnov A.Yu., Chazova I.E.

More about the authors

Journal: Russian Cardiology Bulletin. 2018;13(4): 50‑56

DOI: 10.17116/Cardiobulletin20181304150

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Table of contents

EFFECT OF CHEMOTHERAPY ON THE LENGTH OF TELOMERES IN PATIENTS WITH BREAST CANCER SUFFERING FROM ARTERIAL HYPERTENSION
EFFECT OF CHEMOTHERAPY ON THE LENGTH OF TELOMERES IN PATIENTS WITH BREAST CANCER SUFFERING FROM ARTERIAL HYPERTENSION

To cite this article:

Doroshchuk NA, Doroshchuk AD, Vitsenya MV, et al. Effect of chemotherapy on the length of telomeres in patients with breast cancer suffering from arterial hypertension. Russian Cardiology Bulletin. 2018;13(4):50‑56. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20181304150

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Breast cancer (BC) is one of the most common malignant neoplasm in women. Antitumor therapy causes telomere shortening. The effects of antitumor therapy on telomere length in women with different molecular types of breast cancer and arterial hypertension (AH) remain poorly studied. Objective: to study the effect of antitumor therapy on telomere length in women with different molecular types of breast cancer and hypertension. Materials and methods: the study included women with various molecular types of breast cancer. All patients underwent clinical examination. The comparison group consisted of practically healthy women. The length of telomeric repeats of chromosomes was determined by the method of quantitative polymerase chain reaction in real time before and after chemothermia. Results: The length of telomeric chromosome repeats in women with breast cancer was significantly reduced (p<0,05) before the start of treatment. During chemotherapy in women with hypertension, the length of telomeres was significantly reduced: by 16.2±4.5% (p<0,05) in patients with HER2 + breast cancer and by 12.4±3.8% (p<0, 05) — with triple negative breast cancer. In women with a normal level of arterial blood pressure there was no significant decrease in the length of telomeres (p=0,22). Conclusion: antitumor therapy causes a shortening of the telomere length in women with different molecular types of breast cancer with the presence of hypertension, which can provoke the development and aggravation of cardiovascular diseases.

Keywords:

breast cancer
arterial hypertension
telomere shortening

Authors:

Doroshchuk N.A.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Doroshchuk A.D.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Vitsenya M.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Gavryushina S.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Oschepkova E.V.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

Ageev F.T.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Postnov A.Yu.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Chazova I.E.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

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