The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Doroshchuk N.A.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Doroshchuk A.D.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Vitsenya M.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Gavryushina S.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Oschepkova E.V.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

Ageev F.T.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Postnov A.Yu.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Chazova I.E.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

Effect of chemotherapy on the length of telomeres in patients with breast cancer suffering from arterial hypertension

Authors:

Doroshchuk N.A., Doroshchuk A.D., Vitsenya M.V., Gavryushina S.V., Oschepkova E.V., Ageev F.T., Postnov A.Yu., Chazova I.E.

More about the authors

Journal: Russian Cardiology Bulletin. 2018;13(4): 50‑56

DOI: 10.17116/Cardiobulletin20181304150

Views: 534

Downloaded: 6

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Doroshchuk NA, Doroshchuk AD, Vitsenya MV, et al. . Effect of chemotherapy on the length of telomeres in patients with breast cancer suffering from arterial hypertension. Russian Cardiology Bulletin. 2018;13(4):50‑56. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20181304150

 
МСФ на ЯМ
Close metadata
Recommended articles:
Obesity grade I: a study of real clinical practice in the Russian Fede­ration. Medi­cal Technologies. Asse­ssment and Choice. 2024;(1):83-90
Asso­ciations between components of meta­bolic syndrome and cognitive impairment in patients with schi­zophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3):82-87
Comparative immu­nohistochemistry study of different anti­bodies clones for dete­ction of breast cancer markers (estrogen rece­ptor, progesterone rece­ptor, HER2/neu, Ki-67). Russian Journal of Archive of Pathology. 2024;(2):14-20
Effi­cacy of manual correction of cervical spine osteochondrosis in the treatment of arte­rial hype­rtension syndrome and prediabetes. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(2):12-17
Theory of centralized aero­bic-anaerobic energy bala­nce compensation and non-pharmaceutical treatment methods of arte­rial hype­rtension. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(2):34-39
Cognitive impairment in patients with arte­rial hype­rtension. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):41-48
Complications after one-stage and two-stage breast reco­nstruction depe­nding on the method of reco­nstruction and risk factors. Plastic Surgery and Aesthetic Medi­cine. 2024;(2):16-21
Perforator fasciocutaneous flaps in rese­ctions for breast cancer. Plastic Surgery and Aesthetic Medi­cine. 2024;(2):81-86
The impact of arti­ficial inte­lligence on double reading of mammograms. Russian Journal of Preventive Medi­cine. 2024;(5):32-37
Arte­rial hype­rtension in patients — mili­tary fighting participants. Russian Journal of Preventive Medi­cine. 2024;(5):128-132

Breast cancer (BC) is one of the most common malignant neoplasm in women. Antitumor therapy causes telomere shortening. The effects of antitumor therapy on telomere length in women with different molecular types of breast cancer and arterial hypertension (AH) remain poorly studied. Objective: to study the effect of antitumor therapy on telomere length in women with different molecular types of breast cancer and hypertension. Materials and methods: the study included women with various molecular types of breast cancer. All patients underwent clinical examination. The comparison group consisted of practically healthy women. The length of telomeric repeats of chromosomes was determined by the method of quantitative polymerase chain reaction in real time before and after chemothermia. Results: The length of telomeric chromosome repeats in women with breast cancer was significantly reduced (p<0,05) before the start of treatment. During chemotherapy in women with hypertension, the length of telomeres was significantly reduced: by 16.2±4.5% (p<0,05) in patients with HER2 + breast cancer and by 12.4±3.8% (p<0, 05) — with triple negative breast cancer. In women with a normal level of arterial blood pressure there was no significant decrease in the length of telomeres (p=0,22). Conclusion: antitumor therapy causes a shortening of the telomere length in women with different molecular types of breast cancer with the presence of hypertension, which can provoke the development and aggravation of cardiovascular diseases.

Keywords:

breast cancer
arterial hypertension
telomere shortening

Authors:

Doroshchuk N.A.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Doroshchuk A.D.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Vitsenya M.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Gavryushina S.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Oschepkova E.V.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

Ageev F.T.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Postnov A.Yu.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Chazova I.E.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

List of references:

  1. The global battle with cancer can not be won with the help of treatment alone. World health organization 2014. Accessed 08.08.18. (In Russ.) http://www.who.int/mediacentre/news/releases/2014/cancer-report-20140203/ru/
  2. Berry DA, Cronin KA, Plevritis SK, Fryback DG, Clarke L, Zelen M, Mandelblatt JS, Yakovlev AY, Habbema JD, Feuer EJ. Effect of screening and adjuvant therapy on mortality from breast cancer. The New England Journal of Medicine. 2005;353(17):1784-1792. https://doi.org/10.1056/NEJMoa050518
  3. Stellitano A, Fedele R, Barillà S, Iaria A, Rao CM, Martino M. Chemotherapy and cardiotoxicity in hematologic malignancies. Current Cancer Drug Targets. 2017;17(4):311-324. https://doi.org/10.2174/1568009617666161121141607
  4. Armanios M. Telomeres and age-related disease: how telomere biology informs clinical paradigms. The Journal of Clinical Investigation. 2013;123(3):996-1002. https://doi.org/10.1172/JCI66370
  5. Yeh JK, Wang CY. Telomeres and telomerase in cardiovascular diseases. Genes (Basel). 2016;7(9):E58. https://doi.org/10.3390/genes7090058
  6. Fyhrquist F, Saijonmaa O, Strandberg T. The roles of senescence and telomere shortening in cardiovascular disease. Nature reviews. Cardiology. 2013;10(5):274-283. https://doi.org/10.1038/nrcardio.2013.30
  7. Doroshchuk NA, Tikhaze AK, Lankin VZ, Konovalova GG, Mednikova TK, Postnov AYu, Kukharchuk VV. The influence of oxidative stress on the length of telomeric repeats in chromosomes of white blood cells in patients with different risk of cardiovascular death and patient with coronary artery disease. Kardiologicheskij vestnik. 2017;1:32-36. (In Russ.)
  8. Duggan C, Risques R, Alfano C, Prunkard D, Imayama I, Holte S, Baumgartner K, Baumgartner R, Bernstein L, Ballard-Barbash R, Rabinovitch P, McTiernan A. Change in peripheral blood leukocyte telomere length and mortality in breast cancer survivors. Journal of the National Cancer Institute. 2014;106(4):dju035. https://doi.org/10.1093/jnci/dju035
  9. Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, Ibrahim JG, Jolly TA, Williams G, Carey LA, Drobish A, Gordon BB, Alston S, Hurria A, Kleinhans K, Rudolph KL, Sharpless NE, Muss HB. Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. Journal of the National Cancer Institute. 2014;106(4):dju057. https://doi.org/10.1093/jnci/dju057
  10. Aubert G, Hills M, Lansdorp PM. Telomere length measurement V Caveats and a critical assessment of the available technologies and tools. Mutation Research. 2012;730(1-2):59-67. https://doi.org/10.1016/j.mrfmmm.2011.04.003
  11. Chatterjee S. Telomeres in health and disease. Journal of Oral and Maxillofacial Pathology. 2017;21(1):87-91. https://doi.org/10.4103/jomfp.JOMFP_39_16
  12. Armanios M. Telomeres and age-related disease: How telomere biology informs clinical paradigms. The Journal of Clinical Investigation. 2013.123:996-1002. https://doi.org/10.1172/JCI66370
  13. Doroshchuk NA, Lankin VZ, Tikhaze AK, Odinokova OA, Konovalova GG, Postnov AYu. Oxidative stress and telomere shortening in leukocytes of the blood of patients with newly diagnosed type 2 diabetes. Kardiologicheskij vestnik. 2016;2:56-60. (In Russ.).
  14. Qu S, Wen W, Shu X-O, Chow W-H, Xiang Y-B, Wu J, Ji B-T, Rothman N, Yang G, Cai Q, Gao YT, Zheng W. Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women’s Health Study. American Journal of Epidemiology. 2013;177(7):617-624. https://doi.org/10.1093/aje/kws291
  15. Shen J, Gammon MD, Terry MB, Wang Q, Bradshaw P, Teitelbaum SL, Neugut AI, Santella RM. Telomere length, oxidative damage, antioxidants and breast cancer risk. International Journal of Cancer. 2009;124(7):1637-1643. https://doi.org/10.1002/ijc.24105
  16. Willeit P, Willeit J, Mayr A, Weger S, Oberhollenzer F, Brandstätter A, Kronenberg F, Kiechl S. Telomere length and risk of incident cancer and cancer mortality. Journal of the American Medical Association. 2010;304(1):69-75. https://doi.org/10.1001/jama.2010.897
  17. Benitez-Buelga C, Sanchez-Barroso L, Gallardo M, Apellániz-Ruiz M, Inglada-Pérez L, Yanowski K, Carrillo J, Garcia-Estevez L, Calvo I, Perona R, Urioste M, Osorio A, Blasco MA, Rodriguez-Antona C, Benitez J. Impact of chemotherapy on telomere length in sporadic and familial breast cancer patients. Breast Cancer Research and Treatment. 2015;149(2):385-394. https://doi.org/10.1007/s10549-014-3246-6
  18. Diker-Cohen T, Uziel O, Szyper-Kravitz M, Shapira H, Natur A, Lahav M. The effect of chemotherapy on telomere dynamics: clinical results and possible mechanisms. Leukemia & Lymphoma. 2013;54(9):2023-2029. https://doi.org/10.3109/10428194.2012.757765
  19. M’kacher R, Girinsky T, Colicchio B, Ricoul M, Dieterlen A, Jeandidier E, Heidingsfelder L, Cuceu C, Shim G, Frenzel M, Lenain A, Morat L, Bourhis J, Hempel WM, Koscielny S, Paul JF, Carde P, Sabatier L. Telomere shortening: a new prognostic factor for cardiovascular disease post-radiation exposure. Radiation Protection Dosimetry. 2015;164(1-2):134-137. https://doi.org/10.1093/rpd/ncu296
  20. Ho E, Karimi Galougahi K, Liu CC, Bhindi R, Figtree GA. Biological markers of oxidative stress: applications to cardiovascular research and practice. Redox Biology. 2013;1:483-491. https://doi.org/10.1016/j.redox.2013.07.006
  21. Postnov YV, Orlov SN, Budnikov YY, Doroshchuk AD, Postnov AY. Mitochondrial energy conversion disturbance with decrease in ATP production as a source of systemic arterial hypertension. Pathophysiology. 2007;14(3-4): 195-204. https://doi.org/10.1016/j.pathophys.2007.09.002
  22. Andrisic L, Dudzik D, Barbas C, Milkovic L, Grune T, Zarkovic N. Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer. Redox Biology. 2017;14:47-58. https://doi.org/10.1016/j.redox.2017.08.009
  23. Sosa V, Moliné T, Somoza R, Paciucci R, Kondoh H, LLeonart ME. Oxidative stress and cancer: an overview. Ageing Research Reviews. 2013;12(1):376-390. https://doi.org/10.1016/j.arr.2012.10.004
  24. Klaunig JE, Kamendulis LM, Hocevar BA. Oxidative stress and oxidative damage in carcinogenesis. Toxicologic Pathology. 2010;38(1):96-109. https://doi.org/10.1177/0192623309356453
  25. Fyhrquist F, Saijionmaa O, Strandberg T. Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women’s Health Study. American Journal of Epidemiology. 2013;178(4):662-663. https://doi.org/10.1093/aje/kws291
  26. Lankin VZ, Tikhaze AK. Role of oxidative stress in the genesis of atherosclerosis and diabetes mellitus: a personal look back on 50 years of research. Current Aging Science. 2017;10(1):18-25. https://doi.org/10.2174/1874609809666160926142640

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.