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Mayorov G.B.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Kurbanov S.K.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Vlasova E.E.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Galayutdinov D.M.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Vasiliev V.P.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Shiryaev A.A.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Akchurin R.S.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Calcification in coronary heart disease: issues of diagnosis, prognosis and choice of treatment

Authors:

Mayorov G.B., Kurbanov S.K., Vlasova E.E., Galayutdinov D.M., Vasiliev V.P., Shiryaev A.A., Akchurin R.S.

More about the authors

Journal: Russian Cardiology Bulletin. 2018;13(4): 4‑10

DOI: 10.17116/Cardiobulletin2018130414

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Table of contents

CALCIFICATION IN CORONARY HEART DISEASE: ISSUES OF DIAGNOSIS, PROGNOSIS AND CHOICE OF TREATMENT
CALCIFICATION IN CORONARY HEART DISEASE: ISSUES OF DIAGNOSIS, PROGNOSIS AND CHOICE OF TREATMENT

To cite this article:

Mayorov GB, Kurbanov SK, Vlasova EE, Galayutdinov DM, Vasiliev VP, Shiryaev AA, Akchurin RS. Calcification in coronary heart disease: issues of diagnosis, prognosis and choice of treatment. Russian Cardiology Bulletin. 2018;13(4):4‑10. (In Russ.)
https://doi.org/10.17116/Cardiobulletin2018130414

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Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
 
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Abstract:

Coronary artery calcification (CAC) is highly prevalent in patients with coronary heart disease; it is associated with major adverse cardiovascular events. CAC is a hallmark of atherosclerosis presence and progress and it plays an important role in coronary plaques stabilization. Review includes trials describing pathogenesis, diagnosis of CAC and outcomes after direct myocardial revascularization in patients with coronary heart disease accompanied by calcinosis. There is a need for further data collection about long term results after coronary artery bypass grafting in this group of patients. Currently there is no common medical therapy of CAC.

Keywords:

coronary artery bypass grafting
coronary artery calcification
coronary artery calcification score

Authors:

Mayorov G.B.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Kurbanov S.K.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Vlasova E.E.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Galayutdinov D.M.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Vasiliev V.P.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Shiryaev A.A.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Akchurin R.S.

FGBU National medical research cardiology center of Russia, Moscow, Russia

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References:

  1. Bourantas CV, Zhang YJ, Garg S, Mack M, Dawkins KD, Kappetein AP, Mohr FW, Colombo A, Holmes DR, StÃ¥hle E, Feldman T, Morice MC, de Vries T, Morel MA, Serruys PW. Prognostic Implications of Severe Coronary Calcification in Patients Undergoing Coronary Artery Bypass Surgery: An Analysis of the SYNTAX Study. Catheter Cardiovasc Interv. 2015;85(2):199-206. https://doi.org/10.1002/ccd.25545
  2. Bangalore S, Vlachos HA, Selzer F, Wilensky RL, Kip KE, Williams DO, Faxon DP. Percutaneous coronary intervention of moderate to severe calcified coronary lesions: insights from the National Heart, Lung, and Blood Institute Dynamic Registry. Catheter Cardiovasc Interv. 2011;77:22-28. https://doi.org/10.1002/ccd.22613
  3. Moussa I, Ellis SG, Jones M, Kereiakes DJ, McMartin D, Rutherford B, Mehran R, Collins M, Leon MB, Popma JJ, Russell ME, Stone GW. Impact of coronary culprit lesion calcium in patients undergoing paclitaxel-eluting stent implantation (a TAXUS-IV sub study). Am J Cardiol. 2005;96:1242-1247. https://doi.org/10.1016/j.amjcard.2005.06.064
  4. Tarigopula M, Généreux P, Madhavan MV, Parvataneni R, Weisz G, Mehran R, Stone GW. Revascularization Strategies for Calcified Lesions in Patients Presenting With Acute Coronary Syndromes (From the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial). J Invasive Cardiol. 2016;28(1):10-16.
  5. Kalra SS, Shanahan CM. Vascular calcification and hypertension: cause and effect. Ann Med. 2012;44(suppl 1):85-92. https://doi.org/10.3109/07853890.2012.660498
  6. Doherty TM, Detrano RC. Coronary arterial calcification as an active process: a new perspective on an old problem. Calcif Tissue Int. 1994;54:224-230.
  7. Lui W, Zhang Y, Yu CM, Ji QW, Cai M, Zhao YX, Zhou YJ. Current understanding of coronary artery calcification. Journal of Geriatric Cardiology. 2015;12:668-675. https://doi.org/10.11909/j.issn.1671-5411.2015.06.012
  8. Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res. 2006;99:1044-1059. https://doi.org/10.1161/01.res.0000249379.55535.21
  9. Doherty TM, Detrano RC. Coronary arterial calcification as an active process: a new perspective on an old problem. Calcif Tissue Int. 1994;54:224-230.
  10. Lee RT, Grodzinsky AJ, Frank EH, Kamm RD, Schoen FJ. Structure dependent dynamic mechanical behavior of fibrous caps from human atherosclerotic plaques. Circulation. 1991;83:1764-1770. https://doi.org/10.1161/01.CIR.83.5.1764
  11. Doherty TM, Asotra K, Fitzpatrick LA, Qiao JH, Wilkin DJ, Detrano RC, Dunstan CR, Shah PK, Rajavashisth TB. Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci USA. 2003;100(20):11201-11206. https://doi.org/10.1073/pnas.1932554100
  12. Gagarina NV, Sinitsyn VE, Ternovoj SK. Coronary artery calcification: diagnostic method, clinical results, practical significance. Meditsinskaya vizualizatsiya. 2000;3:23-28. (In Russ.)
  13. Otsuka F, Finn A.V., Virmani R. Do vulnerable and ruptured plaques hide in heavily calcified arteries? Atherosclerosis. 2013;229(1):34-37. https://doi.org/10.1016/j.atherosclerosis.2012.12.032
  14. Uz O, Kardeşoğlu E, Yiğiner O, Baş S, Ipçioğlu OM, Ozmen N, Aparci M, Cingözbay BY, Işilak Z, Cebeci BS. The relationship between coronary calcification and the metabolic markers of osteopontin, fetuin-A, and visfatin. Turk Kardiyol Dern Ars. 2009;37:397-402.
  15. Dhore CR, Cleutjens JP, Lutgens E, Cleutjens KB, Geusens PP, Kitslaar PJ, Tordoir JH, Spronk HM, Vermeer C, Daemen MJ. Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2001;21(12)1998-2003. https://doi.org/10.1161/hq1201.100229
  16. Heiss A, DuChesne A, Denecke B, Grötzinger J, Yamamoto K, Renné T, Jahnen-Dechent W. Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. J Biol Chem. 2003;278(15):13333-13341. https://doi.org/10.1074/jbc.m210868200
  17. Dorai H, Vukicevic S, Sampath TK. Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro. J Cell Physiol. 2000;184:37-45. https://doi.org/10.1002/(sici)1097-4652(200007)184:1<37::aid-jcp4>3.0.co;2-m
  18. Wong ND, Kouwabunpat D, Vo AN, Detrano RC, Eisenberg H, Goel M, Tobis JM. Coronary calcium and atherosclerosis by ultrafast computed tomography in asymptomatic men and women: relation to age and risk factors. Am Heart J. 1994;127:422-430. https://doi.org/10.1016/0002-8703(94)90133-3
  19. Kronmal RA, McClelland RL, Detrano R, Shea S, Lima JA, Cushman M, Bild DE, Burke GL. Risk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the multi-ethnic study of atherosclerosis (MESA). Circulation. 2007;115:2722-2730. https://doi.org/10.1161/circulationaha.106.674143
  20. Sinitsyn VE, Voronov DA, Morozov SP. The degree of coronary artery calcinosis as a prognostic factor of asymptomatic cardiovascular complications: results of metaanalysis. Therapeutic archive. 2006;9:22-26. (In Russ.)
  21. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte MJr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827-832. https://doi.org/10.1016/0735-1097(90)90282-T
  22. Fedotenkov IS, Veselova TN, Ternovoy SK, Sinitsyn VE. Role of multislice computed tomography in the diagnosisof coronary arterial calcification. Kardiologicheskij vestnik. 2007;1:45-48. (In Russ.)
  23. Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, Foster E, Hlatky MA, Hodgson JM, Kushner FG, Lauer MS, Shaw LJ, Smith SCJr, Taylor AJ, Weintraub WS, Wenger NK, Jacobs AK, Smith SCJr, Anderson JL, Albert N, Buller CE, Creager MA, Ettinger SM, Guyton RA, Halperin JL, Hochman JS, Kushner FG, Nishimura R, Ohman EM, Page RL, Stevenson WG, Tarkington LG, Yancy CW. American College of Cardiology Foundation; American Heart Association. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010;56:50-103. https://doi.org/10.1016/j.jacc.2010.09.001
  24. Budoff MJ, Georgiou D, Brody A, Agatston AS, Kennedy J, Wolfkiel C, Stanford W, Shields P, Lewis RJ, Janowitz WR, Rich S, Brundage BH. Ultrafast computed tomography as a diagnostic modality in the detection of coronary artery disease: a multicenter study. Circulation. 1996;93:898-904. https://doi.org/10.1161/01.CIR.93.5.898
  25. Qian Z, Anderson H, Marvasty I, Akram K, Vazquez G, Rinehart S, Voros S. Lesion- and vessel-specific coronary arterycalciumscores are superior to whole-heart Agatstonandvolumescores in the diagnosis of obstructivecoronaryarterydisease. J Cardiovasc Comput Tomogr. 2010;4(6):391-399. https://doi.org/10.1016/j.jcct.2010.09.001
  26. Tuzcu EM, Berkalp B, De Franco AC, Ellis SG, Goormastic M, Whitlow PL, Franco I, Raymond RE, Nissen SE. The dilemma of diagnosing coronary calcification: angiography versus intravascular ultrasound. J Am Coll Cardiol. 1996;27:832-838. https://doi.org/10.1016/0735-1097(95)00537-4
  27. Mintz GS, Nissen SE, Anderson WD, Bailey SR, Erbel R, Fitzgerald PJ, Pinto FJ, Rosenfield K, Siegel RJ, Tuzcu EM, Yock PG. American College of Cardiology Clinical Expert Consensus Document on Standards for Acquisition, Measurement and Reporting of Intravascular Ultrasound Studies (IVUS). J Am Coll Cardiol. 2001;37:1478-1492. https://doi.org/10.1016/S0735-1097(01)01175-5
  28. Yabushita H, Bouma BE, Houser SL, Aretz HT, Jang IK, Schlendorf KH, Kauffman CR, Shishkov M, Kang DH, Halpern EF, Tearney GJ. Characterization of human atherosclerosis by optical coherence tomography. Circulation. 2002;106:1640-1645. https://doi.org/10.1161/01.CIR.0000029927.92825.F6
  29. Kume T, Okura H, Kawamoto T, Yamada R, Miyamoto Y, Hayashida A, Watanabe N, Neishi Y, Sadahira Y, Akasaka T, Yoshida K. Assessment of the coronary calcification by optical coherence tomography. Euro Intervention. 2011;6:768-772. https://doi.org/10.4244/eijv6i6a130
  30. Tan K, Sulke N, Taub N, Sowton E. Clinical and lesion morphologic determinants of coronary angioplasty success and complications: current experience. J Am Coll Cardiol. 1995;25:855-865. https://doi.org/10.1016/0735-1097(94)00462-y
  31. Fitzgerald PJ, Ports TA, Yock PG. Contribution of localized calcium depoÂsits to dissection after angioplasty. An observational study using intravascular ultrasound. Circulation. 1992;86:64-70. https://doi.org/10.1161/01.CIR.86.1.64
  32. Mosseri M, Satler LF, Pichard AD, Waksman R. Impact of vessel calcification on outcomes after coronary stenting. Cardiovasc Revasc Med. 2005;6:147-153. https://doi.org/10.1016/j.carrev.2005.08.008
  33. Liu X, Doi H, Maehara A, Costa Jde RJr, Sano K, Weisz G, Dangas GD, Lansky AJ, Kreps EM, Collins M, Fahy M, Stone GW, Moses JW, Leon MB, Mehran R. A volumetric intravascular ultrasound comparison of early drug-eluting stent thrombosis versus restenosis. J Am Coll Cardiol Intv. 2009;2:428-434. https://doi.org/10.1016/j.jcin.2009.01.011
  34. Zhang BC, Wang C, Li WH, Li DY. Clinical outcome of drug-eluting versus bare metal stents in patients with calcified coronary lesions: a metaanalysis. Intern Med J. 2015;45:203-211. https://doi.org/10.1111/imj.12622
  35. Onuma Y, Tanimoto S, Ruygrok P, Neuzner J, Piek JJ, Seth A, Schofer JJ, Richardt G, Wiemer M, Carrié D, Thuesen L, Dorange C, Miquel-Hebert K, Veldhof S, Serruys PW. Efficacy of everolimus eluting stent implantation in patients with calcified coronary culprit lesions: Two-year angiographic and three-year clinical results from the SPIRIT II study. Catheter Cardiovasc Interv. 2010;76:634-642. https://doi.org/10.1002/ccd.22541
  36. Kuriyama N, Kobayashi Y, Yamaguchi M, Shibata Y. Usefulness of rotatioÂnal atherectomy in preventing polymer damage of everolimus-eluting stent in calcified coronary artery. J Am Coll Cardiol Intv. 2011;4:588-589. https://doi.org/10.1016/j.jcin.2010.11.017
  37. Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Nallamothu BK, Ting HH. 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Circulation. 2011;124:574-651. https://doi.org/10.1161/CIR.0b013e31823ba622
  38. Kume T, Okura H, Kawamoto T, Akasaka T, Toyota E, Neishi Y, Watanabe N, Sukmawan R, Yamada R, Sadahira Y, Yoshida K. Assessment of the histological characteristics of coronary arterial plaque with severe calcification. Circ J. 2007;71:643-647. https://doi.org/10.1253/circj.71.643
  39. Zimarino M, Corcos T, Bramucci E, Tamburino C. Rotational atherectomy: a «survivor» in the drug-eluting stent era. Cardiovasc Revasc Med. 2012;13:185-192. https://doi.org/10.1016/j.carrev.2012.03.002
  40. Lee Y, Tanaka A, Mori N, Yoshimura T, Nakamura D, Taniike M, Makino N, Egami Y, Shutta R, Tanouchi J, Nishino M. Thin-strut drug-eluting stents are more favorable for severe calcified lesions after rotational atherectomy than thick-strut drug-eluting stents. J Invasive Cardiol. 2014;26:41-45.
  41. Bittl JA, Sanborn TA, Tcheng JE, Siegel RM, Ellis SG. Clinical success, complications and restenosis rates with excimer laser coronary angioplasty. The percutaneous excimer laser coronary angioplasty registry. Am J Cardiol. 1992;70:1533-1539. https://doi.org/10.1016/0002-9149(92)90453-6
  42. Fernandez JP, Hobson AR, McKenzie D, Shah N, Sinha MK, Wells TA, Levy TM, Swallow RA, Talwar S, O’Kane PD. Beyond the balloon: excimer coronary laser atherectomy used alone or in combination with rotational atherectomy in the treatment of chronic total occlusions, non-crossable and non-expansible coronary lesions. Euro Intervention. 2013;9:243-250. https://doi.org/10.4244/EIJV9I2A40
  43. Chambers JW, Feldman RL, Himmelstein SI, Bhatheja R, Villa AE, Strickman NE, Shlofmitz RA, Dulas DD, Arab D, Khanna PK, Lee AC, Ghali MG, Shah RR, Davis TP, Kim CY, Tai Z, Patel KC, Puma JA, Makam P, Bertolet BD, Nseir GY. Pivotal trial to evaluate the safety and efficacy of the orbital atherectomy system in treating de novo, severely calcified coronary lesions (ORBIT II). JACC Cardiovasc Interv. 2014;7:510-518. https://doi.org/10.1016/j.jcin.2014.01.158
  44. Castagna MT, Mintz GS, Ohlmann P, Kotani J, Maehara A, Gevorkian N, Cheneau E, Stabile E, Ajani AE, Suddath WO, Kent KM, Satler LF, Pichard AD, Weissman NJ. Incidence, location, magnitude, and clinical correlates of saphenous vein graft calcification: an intravascular ultrasound and angiographic study. Circulation. 2005;111:1148-1152. https://doi.org/10.1161/01.CIR.0000157160.69812.55
  45. Ertelt K, Généreux P, Mintz GS, Reiss GR, Kirtane AJ, Madhavan MV, Fahy M, Williams MR, Brener SJ, Mehran R, Stone GW. Impact of the severity of coronary artery calcification on clinical events in patients undergoing coronary artery bypass grafting (from the Acute Catheterization and Urgent Intervention Triage Strategy Trial). Am J Cardiol. 2013;112(11):1730-1737. https://doi.org/10.1016/j.amjcard.2013.07.038
  46. Schmermund A, Achenbach S, Budde T, Buziashvili Y, Förster A, Friedrich G, Henein M, Kerkhoff G, Knollmann F, Kukharchuk V, Lahiri A, Leischik R, Moshage W, Schartl M, Siffert W, Steinhagen-Thiessen E, Sinitsyn V, Vogt A, Wiedeking B, Erbel R. Effect of intensive versus standard lipid-lowering treatment with atorvastatin on the progression of calcified coronary atherosclerosis over 12 months: a multicenter, randomized, double-blind trial. Circulation. 2006;113:427-437. https://doi.org/10.1161/circulationaha.105.568147
  47. Ferencik M, Chatzizisis YS. Statins and the coronary plaque «calcium paradox»: Insights from non-invasive and invasive imaging. Atherosclerosis. 2015;241:783-785. https://doi.org/10.1016/j.atherosclerosis.2015.05.021
  48. Motro M, Shemesh J. Calcium channel blocker nifedipine slows down progression of coronary calcification in hypertensive patients compared with diuretics. Hypertension. 2001;37:1410-1413. https://doi.org/10.1161/01.HYP.37.6.1410
  49. Manson JE, Allison MA, Rossouw JE, Carr JJ, Langer RD, Hsia J, Kuller LH, Cochrane BB, Hunt JR, Ludlam SE, Pettinger MB, Gass M, Margolis KL, Nathan L, Ockene JK, Prentice RL, Robbins J, Stefanick ML. WHI and WHI-CACS Investigators. Estrogen therapy and coronary-artery calcification. N Engl J Med. 2007;356:2591-2602. https://doi.org/10.1056/NEJMoa071513
  50. Li K, Kaaks R, Linseisen J, Rohrmann S. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the EuroÂpean Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart. 2012;98:920-925. https://doi.org/10.1136/heartjnl-2011-301345
  51. Spence LA, Weaver CM. Calcium intake, vascular calcification, and vascular disease. Nutr Rev. 2013;71(1):15-22. https://doi.org/10.1111/nure.12002
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