The study explored the association between circulating T-helper cells, chemokine CCL7 and expression of CCR4 receptor with the severity of coronary atherosclerosis and the presence of hemodynamically significant stenoses of the coronary arteries. The effects of the inflammatory response, which occurs in response to the implantation of a coronary stent, in the levels of T-helpers and CCL17 and expression of CCR4 were also evaluated. Materials and methods. The study involved 82 male patients, who underwent coronary angiography and 10 heathy individuals. Patients were divided into 4 groups based on the severity of coronary atherosclerosis. In addition, all patients were divided into 2 groups according to the presence of hemodynamically significant stenoses of the coronary arteries. The severity of atherosclerotic coronary lesions was evaluated using the Gensini score. All patients underwent determination of circulating T-helper cells in the peripheral blood and expression of CCR4 receptor by flow cytometry, CCL17 by quantitative immunoassay ELISA. Results. In our study significant correlation the blood level of T-helper cells and the expression of the CCR4 receptor expression by T-lymphocytes in general, and the T-helper cells in particular with severity of coronary atherosclerosis was detected. The level of chemokine CCL17 significantly increased at 24 hours after coronary stenting.