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Lobastov K.V.
Kafedra obshcheĭ khirurgii lechebnogo fakul'teta GOU VPO RGMU Roszdrava, Moskva
Dement’eva G.I.
N.I. Pirogov Russian National Research Medical University;
City Clinical Hospital No24, Moscow, Russia
Laberko L.A.
Kafedra obshcheĭ khirurgii lechebnogo fakul'teta Rossiĭskogo nauchno-issledovatel'skogo meditsinskogo universiteta im. N.I. Pirogova, Moskva
Current Insights on the Etiology and Pathogenesis of Venous Thrombosis: Virchow’s Triad Revision
Journal: Journal of Venous Disorders. 2019;13(3): 227‑235
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To cite this article:
Lobastov KV, Dement’eva GI, Laberko LA. Current Insights on the Etiology and Pathogenesis of Venous Thrombosis: Virchow’s Triad Revision. Journal of Venous Disorders.
2019;13(3):227‑235. (In Russ.)
https://doi.org/10.17116/flebo201913031227
A review of the current literature is devoted to the etiology and pathogenesis of venous thrombosis regarding their accordance with the classical Virchow’s triad. Three main components of venous stasis (reduced blood flow velocity, blood stagnation, vascular dilatation) and their effect on the endothelial function through shear stress are analyzed. The nature and diagnosis of hypercoagulation in surgery, pregnancy, hormonal medication intake, hyperhomocysteinemia, antiphospholipid syndrome and cancer are reviewed. We paid a particular attention to the role of microparticles in mechanisms of initiation and progression of thrombotic process. The role of endothelium in blood rheology, function of Weibel—Palade bodies and the role of adhesive molecules in initiation of thrombosis are discussed. We determined the role of neutrophils, neutrophil extracellular traps (NETs) and inflammatory reaction in genesis of thrombosis. We judged the compliance of all newly discovered pathogenetic mechanisms of thrombosis with the classical Virchow’s triad.
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Lobastov K.V.
Kafedra obshcheĭ khirurgii lechebnogo fakul'teta GOU VPO RGMU Roszdrava, Moskva
Dement’eva G.I.
N.I. Pirogov Russian National Research Medical University;
City Clinical Hospital No24, Moscow, Russia
Laberko L.A.
Kafedra obshcheĭ khirurgii lechebnogo fakul'teta Rossiĭskogo nauchno-issledovatel'skogo meditsinskogo universiteta im. N.I. Pirogova, Moskva
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