Aim of the study. To evaluate the five-year results of various treatment modalities in the patients with teleangiectasias (TAE) and reticular varicosis (RV) of the lower extremities. Material and methods. The study included 726 patients. The five-year results of the treatment were analysed in 570 of them. 188 (25.9%) patients presented with TAE, 442 (60.8%) suffered TAE in combination with RV, and 96 (13.3%) had RV alone. Thirty five (4.8) patients exhibited local, 635 (87.5%) multifocal, and 56 (7.7%) diffuse TAE lesions. 617 (85.0%) patients complained of fatigue, pain and the feeling of heaviness in the lower extremities. The patients were allocated to three groups depending on the extent of the treatment. The patients of group 1 (n=61) underwent microsclerotherapy alone, those in group 2 (n=396) were treated by microsclerotherapy in combination with conservative therapy, and patients of group 3 (n=113) were given microsclerotherapy combined with conservative therapy and simultaneous elimination of risk factors (discontinuation of hormonal contraceptive agents, reduction to a minimum of static loading and hypodynamia, correction of the body weight). Results. The severe and progressive disease was recorded in 29.3% and 60.7% of the patients respectively in group 1. 91.8% of the patients in these group needed repeated microsclerotherapy. 55.8% of the patients of group 3 were free from the disease while 41.5% of them experienced its moderate progression. Primary microsclerotherapy in this group had positive outcome in 49.6% of the patients. Only 47 (8.2%) women were discontented with the results of the treatment. There were four times fewer such patients in group 3 than in group 1. Comparative dynamics of the quality of life (QL) indices in the patients of groups 1 and 3 was estimated with the use of the CIVIQ2 questionnaire. It was shown that the QL index in group 3 was significantly reduced (p=0.00002). Conclusion. The best results of the treatment of TAE and RV can be ontained by combining microsclerotherapy, conservative therapy, and elimination of the risk factors.