This paper is designed to analyse the applications of various modern approaches to sclerotherapy and the role of this method in the combined treatment of the patients presenting with primary varicose veins. During the last 5 years, a total of 1772 sclerotherapeutic procedures were applied to treat 500 patients. They included 258 patients who underwent 972 sessions of liquid sclerotherapy and 242 patients given 800 sessions of micro-foam sclerotherapy. Thirty two patients were treated by micro-foam sclerotherapy of minor subcutaneous veins (45 procedures) and 48 ones by echoscleroobliteration of compromised perforating veins (66 procedures including 48 and 18 liquid and microfoam sclerotherapy, respectively).