The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2024
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Streltsov Yu.A.

Loginov Moscow Clinical Scientific Center

Danilov M.A.

Loginov Moscow Clinical Scientific Center

Shishin K.V.

Loginov Moscow Clinical Scientific Center

Leontiev A.V.

Loginov Moscow Clinical Scientific Center

Baychorov A.B.

Loginov Moscow Clinical Scientific Center

Tsvirkun V.V.

Loginov Moscow Clinical Scientific Center

Intraoperative fluorescence mapping of lymph nodes in colon cancer

Authors:

Streltsov Yu.A., Danilov M.A., Shishin K.V., Leontiev A.V., Baychorov A.B., Tsvirkun V.V.

More about the authors

Journal: Endoscopic Surgery. 2023;29(4): 5‑12

DOI: 10.17116/endoskop2023290415

Views: 2341

Downloaded: 37

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Streltsov YuA, Danilov MA, Shishin KV, Leontiev AV, Baychorov AB, Tsvirkun VV. Intraoperative fluorescence mapping of lymph nodes in colon cancer. Endoscopic Surgery. 2023;29(4):5‑12. (In Russ.)
https://doi.org/10.17116/endoskop2023290415

Подписка 2025 (Endoscopic Surgery)
МСФ на ЯМ
Close metadata

OBJECTIVE

Evaluation of the effectiveness of different methods of introducing indocyanine green (ICG) for fluorescent mapping of lymph nodes during operations for colon cancer.

MATERIAL AND METHODS

The study included 32 patients with colon cancer, in whom fluorescent mapping of the ICG lymph nodes was used during surgical intervention to objectify the implementation of D3-lymphadenectomy.

RESULTS

When ICG was used, fluorescence of lymph nodes was determined in 28 (87.5%) patients. The duration of operations in these patients averaged 199.1±44.8 minutes. The average number of detected lymph nodes reached 25.4±10.6, of which 1.25±2.59 were metastatically affected. An increase in the volume of lymphadenectomy due to the use of ICG was performed in 3 (10.7%) cases. The number of fluorescent from the total number of detected lymph nodes was 77.1±12.7%. When comparing the results of submucosal and subserous ICG administration methods used in 10 and 22 patients, respectively, there were no statistically significant gender differences in the frequency of fluorescence of the lymph nodes, the number of fluorescent lymph nodes, and the duration of the surgical intervention. There were no complications associated with the use of ICG.

CONCLUSION

The use of ICG in colon cancer surgery for fluorescent lymph nodes mapping is an informative, easily reproducible way for improving lymphadenectomy quality. Various methods of ICG administration near the tumor are comparable; intraoperative submucosal administration of ICG is associated with a longer operative time. The choice of the injection method can be carried out depending on tumor localization, endoscopic services availability, and surgeon preferences.

Keywords:

indocyanine green
colon cancer
surgical navigation
lymph nodes mapping

Authors:

Streltsov Yu.A.

Loginov Moscow Clinical Scientific Center

Danilov M.A.

Loginov Moscow Clinical Scientific Center

Shishin K.V.

Loginov Moscow Clinical Scientific Center

Leontiev A.V.

Loginov Moscow Clinical Scientific Center

Baychorov A.B.

Loginov Moscow Clinical Scientific Center

Tsvirkun V.V.

Loginov Moscow Clinical Scientific Center

Received:

27.07.2022

Accepted:

27.09.2022

List of references:

  1. Guyer DR, Puliafito CA, Monés JM, Friedman E, Chang W, Verdooner SR. Digital indocyanine-green angiography in chorioretinal disorders. Ophthalmology. 1992;99(2):287-291.  https://doi.org/10.1016/S0161-6420(92)31981-5
  2. Alander JT, Kaartinen I, Laakso A, Pätilä T, Spillmann T, Tuchin VV, Venermo M, Välisuo P. A Review of indocyanine green fluorescent imaging in surgery. Int J Biomed Imag. 2012;2012:940585. https://doi.org/10.1155/2012/940585
  3. Klais CM, Ober MD, Yannuzzi LA. Indocyanine green angiography: General aspects and interpretation. In Retinal Angiography and Optical Coherence Tomography. Ed. Fernando Arevalo F. Berlin, Germany, 2009.
  4. Levesque E, Martin E, Dudau D, Lim C, Dhonneur G, Azoulay D. Current use and perspective of indocyanine green clearance in liver diseases. Anaesth Crit Care Pain Med. 2016;35(1):49-57.  https://doi.org/10.1016/j.accpm.2015.06.006
  5. Nagata K, Endo S, Hidaka E, Tanaka J, Kudo SE, Shiokawa A. Laparoscopic sentinel node mapping for colorectal cancer using infrared ray laparoscopy. Anticancer Res. 2006:26(3):2307-2311.
  6. Watanabe M, Tsunoda A, Narita K, Kusano M, Miwa M. Colonic tattooing using fluorescence imaging with light-emitting diode-activated indocyanine green: a feasibility study. Surgery today. 2009;39(3):214-218.  https://doi.org/10.1007/S00595-008-3849-9
  7. Reinhart MB, Huntington CR, Blair LJ, Heniford BT, Augenstein VA. Indocyanine Green: Historical Context, Current Applications, and Future Considerations. Surg Innovat. 2016;23(2):166-175.  https://doi.org/10.1177/1553350615604053
  8. Liberale G, Bourgeois P, Larsimont D, Moreau M, Donckier V, Ishizawa T. Indocyanine green fluorescence-guided surgery after IV injection in metastatic colorectal cancer: A systematic review. Eur J Surg Oncol. 2017;43(9):1656-1667. https://doi.org/10.1016/J.EJSO.2017.04.015
  9. Son GM, Ahn HM, Lee IY, Ha GW. Multifunctional indocyanine green applications for fluorescence-guided laparoscopic colorectal surgery. Ann Coloproctol. 2021;37(3):133-140.  https://doi.org/10.3393/AC.2021.05.07
  10. Andersen HS, Bennedsen ALB, Burgdorf SK, Eriksen JR, Eiholm S, Toxværd A, Riis LB, Rosenberg J, Gögenur I. In vivo and ex vivo sentinel node mapping does not identify the same lymph nodes in colon cancer. Int J Colorectal Dis. 2017;32(7):983-990.  https://doi.org/10.1007/s00384-017-2777-9
  11. Nishigori N, Koyama F, Nakagawa T, Nakamura S, Ueda T, Inoue T, Kawasaki K, Obara S, Nakamoto T, Fujii H, Nakajima Y. Visualization of Lymph/Blood Flow in Laparoscopic Colorectal Cancer Surgery by ICG Fluorescence Imaging (Lap-IGFI). Ann Surg Oncol. 2016;23:266-274.  https://doi.org/10.1245/s10434-015-4509-0
  12. Van Der Pas MHGM, Ankersmit M, Stockmann HB, Silvis R, van Grieken NC, Bril H, Meijerink WJ. Laparoscopic sentinel lymph node identification in patients with colon carcinoma using a near-infrared dye: Description of a new technique and feasibility study. J Laparoendosc Advanc Surg Techniq. 2013;23(4):367-371.  https://doi.org/10.1089/lap.2012.0407
  13. Bashankaev BN, Shishin KV, Veselov VV, Mitrakov AA, Velikanov EV. Endoscopic tattooing of colorectal neoplasms and laparoscopic surgery: technical aspects and recommendations. Khirurgiya. Zurnal im. N.I. Pirogova (Pirogov Russian Journal of Surgery). 2017;10:77-81. (In Russ). https://doi.org/10.17116/hirurgia20171077-81
  14. Japanese Society for Cancer of the Colon and Rectum. Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma: the 3d English Edition [Secondary Publication]. J Anus, Rectum Colon. 2019;3(4):175-195.  https://doi.org/10.23922/jarc.2019-018
  15. AJCC Cancer Staging Manual. 8th ed. ed. MB Amin, SB Edge, FL Greene. Switzerland: Springer, 2017.
  16. Bykasov SA, Sidorov DV, Lozhkin MV, Grishin NA, Bruslinskaya AB, Karachun AM, Petrov AS, Panayotti LL. Results of D3 lymph node dissection in colon cancer.. Onkologiya. Zhurnal im. P.A. Gerzena (P.A. Herzen Journal of Oncology). 2020;9(2):9-15. (In Russ.). https://doi.org/10.17116/onkolog202090219
  17. Carrara A, Motter M, Amabile D, Pellecchia L, Moscatelli P, Pertile R, Barbareschi M, Decarli NL, Ferrari M, Tirone G. Predictive value of the sentinel lymph node procedure in the staging of non-metastatic colorectal cancer. Int J Colorectal Dis. 2020;35(10):1921-1928. https://doi.org/10.1007/s00384-020-03654-3
  18. Currie AC, Brigic A, Thomas-Gibson S, Suzuki N, Moorghen M, Jenkins JT, Faiz OD, Kennedy RH. A pilot study to assess near infrared laparoscopy with indocyanine green (ICG) for intraoperative sentinel lymph node mapping in early colon cancer. Eur J Surg Oncol. 2017;43(11):2044-2051. https://doi.org/10.1016/j.ejso.2017.05.026
  19. Edge SB, Compton CC. The american joint committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Anna Surg Oncol. 2010;17(6):1471-1474. https://doi.org/10.1245/s10434-010-0985-4
  20. Kusano M, Tajima Y, Yamazaki K, Kato M, Watanabe M, Miwa M. Sentinel node mapping guided by indocyanine green fluorescence imaging: A new method for sentinel node navigation surgery in gastrointestinal cancer. Digest Surg. 2008;25(2):103-108.  https://doi.org/10.1159/000121905
  21. Watanabe J, Ota M, Suwa Y, Ishibe A, Masui H, Nagahori K. Real-time indocyanine green fluorescence imaging-guided complete mesocolic excision in laparoscopic flexural colon cancer surgery. Dis Colon Rectum. 2016;59(7):701-705.  https://doi.org/10.1097/DCR.0000000000000608
  22. O’Connell JB, Maggard MA, Ko CY. Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J National Cancer Institute. 2004;96(19):1420-1425. https://doi.org/10.1093/jnci/djh275

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.