The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Sazhin A.V.

Pirogov Russian National Research Medical University

Ivakhov G.B.

Pirogov Russian National Research Medical University & ,V.S. Savel’ev University Faculty Clinic, Moscow, Russia

Stradymov E.A.

Pirogov Russian National Research Medical University & ,V.S. Savel’ev University Faculty Clinic, Moscow, Russia

Petukhov V.A.

Department of faculty surgery named after S.I. Spasokukotskyi, School of general medicine, Pirogov Russian National Research Medical University, Moscow, Russia

Surgical treatment of perforated peptic ulcers complicated by diffuse peritonitis: laparotomy or laparoscopy? (Part 1) (in Russian only)

Authors:

Sazhin A.V., Ivakhov G.B., Stradymov E.A., Petukhov V.A.

More about the authors

Journal: Endoscopic Surgery. 2019;25(3): 51‑58

Read: 19820 times


To cite this article:

Sazhin AV, Ivakhov GB, Stradymov EA, Petukhov VA. Surgical treatment of perforated peptic ulcers complicated by diffuse peritonitis: laparotomy or laparoscopy? (Part 1) (in Russian only). Endoscopic Surgery. 2019;25(3):51‑58. (In Russ.)
https://doi.org/10.17116/endoskop20192503151

Recommended articles:
Redo anti­reflux surgery: a comparative evaluation of lapa­roscopic and robot-assisted techniques. Russian Journal of Evidence-Based Gastroenterology. 2025;(3):14-20
“Classical” sacrocolpopexy as a method of surgical correction of apical geni­tal prolapse. Russian Bulletin of Obstetrician-Gynecologist. 2025;(5):92-97
Endo­metriosis of the diaphragm. Russian Bulletin of Obstetrician-Gynecologist. 2025;(6):24-28
Simple liver cyst complicated by fistula into abdo­minal wall: a case report. Piro­gov Russian Journal of Surgery. 2026;(1):116-120

References:

  1. Krylov NN, Vinnichuk DA. Perforated peptic ulcer: pathomorphosis, collisions and trends. Vrach. 2012;1:15-20 (In Russ.)
  2. Kurbanov FS, Baloglanov DA, Sushko AN, Asadov SA. Operations of the minimum volume in the surgical treatment of perforated duodenal ulcers. Khirurgiya. Zhurnal im. N.I. Pirogova. 2011;3:44-49 (In Russ.)
  3. Bertleff MJ, Lange JF. Perforated peptic ulcer disease: a review of history and treatment. Dig Surg. 2010;27:161-169. https://doi.org/10.1159/000264653
  4. Canoy DS, Hart AR, Todd CJ. Epidemiology of duodenal ulcer perforation: a study on hospital admissions in Norfolk, United Kingdom. World J Surg. 2011;35(4):811-116. https://doi.org/10.1007/s00268-010-0917-2
  5. Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion. 2011;84:102-113.
  6. Thorsen K, Søreide JA, Kvaløy JT, Glomsaker T, Søreide K. Epidemiology of perforated peptic ulcer: Age- and gender-adjusted analysis of incidence and mortality. World J Gastroenterol. 2013;21:19(3):347-354.
  7. Wysocki A, Budzyński P, Kulawik J, Drożdż W. Changes in the Localization of Perforated Peptic Ulcer and its Relation to Gender and Age of the Patients throughout the Last 45 Years. World J Surg. 2011;35(4):811-816. https://doi.org/10.1007/s00268-010-0917-2
  8. Zelickson MS, Bronder CM, Johnson BL, Camunas JA, Smith DE, Rawlinson D, Von S, Stone HH, Taylor SM. Helicobacter pylori is not the predominant etiology for peptic ulcers requiring operation. Am Surg. 2011;77:1054-1060.
  9. Sazhin VP, Bronshtein PG, Zaitsev OV, Kondrus’ IV, Krivtsov GA, Lobankov VM, Sovtsov SA, Prudkov MI, Fedorov AV, Khripun AI, Yudin VA. National clinical recommendations «perforated peptic ulcer». XII s’ezd khirurgov Rossii «Aktual’nye voprosy khirurgii». Rostov-na-Donu, 7—9 oktyabrya 2015 g. (In Russ.)
  10. Antonov ON, Aleksandrov AV, Negrebova MM, Rybal’chenko AV. Influence of the method of surgical treatment in patients with perforated peptic ulcers on the results in the long-term period. Materialy III s»ezda khirurgov yuga Rossii s mezhdunarodnym uchastiem. 2013;89-90. (In Russ.)
  11. Baloglanov DA. Surgical treatment of perforated duodenal ulcers. Khirurgiya. 2010;11:76-78. (In Russ.)
  12. Gostishchev VK, Evseev MA, Golovin RA. Radical surgical interventions in the treatment of patients with perforated gastroduodenal ulcers. Khirurgiya. 2009;3:10-16. (In Russ.)
  13. Møller MH, Adamsen S, Wøjdemann M, Møller AM: Perforated peptic ulcer: how to improve outcome? Scand J Gastroenterol. 2009;44:15-22. https://doi.org/10.1080/00365520802307997
  14. Svanes C. Trends in perforated peptic ulcer: incidence, etiology, treatment and prognosis. World J Surg. 2000;24:277-283. https://doi.org/10.1007/s002689910045
  15. Thorsen K, Glomsaker TB, von Meer A, Søreide K, Søreide JA. Trends in diagnosis and surgical management of patients with perforated peptic ulcer. J Gastrointest Surg. 2011;15:1329-1335. https://doi.org/10.1007/s11605-011-1482-1
  16. Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, Søreide JA. Perforated peptic ulcer. Lancet. 2015;386(10000):1288-1298. https://doi.org/10.1016/S0140-6736(15)00276-7
  17. Lunevicius R, Morkevicius M. Systematic review comparing laparoscopic and open repair for perforated peptic ulcer. Br J Surg. 2005;92:1195-1207.
  18. So JB, Yam A, Cheah WK, Kum CK, Goh PM. Risk factors related to operative mortality and morbidity in patients undergoing emergency gastrectomy. Br J Surg. 2000;87:1702-1707.
  19. Chalya PL, Mabula JB, Koy M, McHembe MD, Jaka HM, Kabangila R, Chandika AB, Gilyoma JM. Clinical profile and outcome of surgical treatment of perforated peptic ulcers in Northwestern Tanzania: A tertiary hospital experience. World J Emerg Surg. 2011;6:31. https://doi.org/10.1186/1749-7922-6-31
  20. Sharma SS, Mamtani MR, Sharma MS, Kulkarni H. A prospective cohort study of postoperative complications in the management of perforated peptic ulcer. BMC Surg. 2006;6:8. https://doi.org/10.1186/1471-2482-6-8
  21. Lee SC, Fung CP, Chen HY, Li CT, Jwo SC, Hung YB, See LC, Liao HC, Loke SS, Wang FL, Lee JC. Candida peritonitis due to peptic ulcer perforation: incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B. Diagn Micro Infect Dis. 2002;44:23-27.
  22. Buck DL, Vester-Andersen M, Moller MH. Prompt Surgery Is Critical for Survival in Patients With Perforated Peptic Ulcer. Br J Surg. 2013;100:1045-1049.
  23. Møller MH, Adamsen S, Thomsen RW, Møller AN. Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation. Br J Surg. 2011;98(6):802-810. https://doi.org/10.1002/bjs.7429
  24. Gupta S, Kaushik R, Sharma R, Attri A. The management of large perforations of duodenal ulcers. BMC Surg. 2005;5:15.
  25. Søreide K, Thorsen K, Søreide JA. Strategies to improve the outcome of emergency surgeryfor perforated peptic ulcer. BJS. 2014;101:51-64.
  26. Liu L, Chiu PW, Lam PK, et al. Effect of local injection of mesenchymal stem cells on healing of sutured gastric perforation in an experimental model. Br J Surg. 2015;102(2):158-168.
  27. Bergström M, Vázquez JA, Park PO. Self-expandable metal stents as a new treatment option for perforated duodenal ulcer. Endoscopy. 2013;45(3):222-225.
  28. Bonin EA, Moran E, Gostout CJ, McConico AL, Zielinski M, Bingener J. Natural orifice transluminal endoscopic surgery for patients with perforated peptic ulcer. Surg Endosc. 2012;26:1534-1538.
  29. Chaudhary A, Bose SM, Gupta NM, Wig JD, Khanna SK. Giant Perforations of Duodenal Ulcer. Ind J Gastroenterol. 1991;10:14-15.
  30. Cranford CA, Olson RO, Bradley EL III. Gastric Disconnection in the Management of Perforated Giant Duodenal Ulcer. Am J Surg. 1988;155:439-342.
  31. Hashiba K, Carvalho AM, Diniz G Jr, Barbosa de Aridrade N, Guedes CA, Siqueira Filho L, Lima CA, Coehlo HE, de Oliveira RA. Experimental endoscopic repair of gastric perforations with an omental patch and clips. Gastrointestinal Endosc. 2001;54:500-504.
  32. Jani K, Saxena AK. Management of Large Sized Duodenal Peptic Perforations by Omental Plugging — A New Technique: A Prospective Randomised Study of 100 patients. Ind J Surg. 2000;62:134-138.
  33. Karanjia ND, Shanahan DJ, Knight MJ. Omental patching of a large perforated duodenal ulcer: a new method. Br J Surg. 1993;80:65.
  34. Mcllrath DC, Larson RH. Surgical management of Large Perforations of the Duodenum. Surg Clin North Am. 1971;51:857-861.
  35. Sharma D, Saxena A, Rahman H, Raina VK, Kapoor JP. ‘Free Omental Plug’: A Nostalgic Look at an Old and Dependable Technique for Giant Peptic Perforations. Dig Surg. 2000;17:216-218. https://doi.org/10.1159/000018837
  36. Menekse E, Kocer B, Topcu R, Olmez A, Tez M, Kayaalp C. A practical scoring system to predict mortality in patients with perforated peptic ulcer. World J Emerg Surg. 2015;10:7. https://doi.org/10.1186/s13017-015-0008-7
  37. Seow JG, Lim YR, Shelat VG. Low serum albumin may predict the need for gastric resection in patients with perforated peptic ulcer. Eur J Trauma Emerg Surg. 2017;43(3):293-298. https://doi.org/10.1007/s00068-016-0669-2
  38. Chung KT, Shelat VG. Perforated peptic ulcer — an update. World WJGS. Perforated peptic ulcer. J Gastrointest Surg. 2017;9(1):1-12.
  39. Millat B, Fingerhut A, Borie F. Surgical treatment of complicated duodenal ulcers: controlled trials. World J Surg. 2000;24:299-306.
  40. Sartelli M, Chichom-Mefire A, Labricciosa FM, Hardcastle T, Abu-Zidan FM, Adesunkanmi AK, Ansaloni L, Bala M. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intraabdominal infections. World J Emerg Surg. 2017;12:36. https://doi.org/10.1186/s13017-017-0148-z
  41. Cellan-Jones CJ. A Rapid Method of Treatment in Perforated Duodenal Ulcer. British Medical Journal. 1929;1:1076-1077.
  42. Graham RR. The Treatment of Perforated Duodenal Ulcers. Surg Gynaecol Obstet. 1937;64:235-238.
  43. Lo HC, Wu SC, Huang HC, Yeh CC, Huang JC, Hsieh CH. Laparoscopic simple closure alone is adequate for low risk patients with perforated peptic ulcer. World J Surg. 2011;35:1873-1878.
  44. Mouret P, Francois Y, Vignal J, et al. Laparoscopic treatment of perforated peptic ulcer. Br J Surg. 1990;77:1006.
  45. Nathanson LK, Easter DW, Cuschieri A. Laparoscopic repair/peritoneal toilet of perforated duodenal ulcer. Surg Endosc. 1990;4:232-233.
  46. Agresta F, Ciardo LF, Mazzarolo G, Michelet I, Orsi G, Trentin G, Bedin N. Peritonitis: laparoscopic approach. World J Emerg Surg. 2006;24(1):9. https://doi.org/10.1186/1749-7922-1-9
  47. Neudecker J, Sauerland S, Neugebauer E, Bergamaschi R, Bonjer HJ, Cuschieri A, Fuchs KH, Jacobi Ch, Jansen FW, Koivusalo AM, Lacy A, McMahon MJ, Millat B, Schwenk W. Surg Endosc. The European Association for Endoscopic Surgery clinical practice guideline on the pneumoperitoneum for laparoscopic surgery. Surg Endosc. 2002;16(7):1121-1143. https://doi.org/10.1007/s00464-001-9166-7
  48. Di Saverio S, Bassi M, Smerieri N, Masetti M, Ferrara F, Fabbri C, Ansaloni L, Ghersi S, Serenari M, Coccolini F, Naidoo N, Sartelli M, Tugnoli G, Catena F, Cennamo V, Jovine E. Diagnosis and treatment of perforated or bleeding peptic ulcers: 2013 WSES position paper. World J Emerg Surg. 2014;9:45. https://doi.org/10.1186/1749-7922-9-45
  49. Zhou C, Wang W, Wang J, Zhang X, Zhang Q, Li B, Xu Z. An Updated Meta-Analysis of Laparoscopic Versus Open Repair for Perforated Peptic Ulcer. Sci Rep. 2015;5:13976. https://doi.org/10.1038/srep13976
  50. Flore V, Ion P, Ciprian D, Amadeus D, Mirela F, Cristi T. Laparoscopic repair of perforated peptic ulcer: review. Minerva Chir. 2018 Jan 23. https://doi.org/10.23736/S0026-4733.18.07603-4
  51. Antoniou SA, Antoniou GA, Koch OO. Meta-analysis of laparoscopic versus open repair of perforated peptic ulcer. Jsls. 2013;17(1):15-22.
  52. Sanabria A, Villegas MI, Morales Uribe CH. Laparoscopic repair for perforated peptic ulcer disease. Cochrane Database Syst Rev. 2013;2:Cd004778.
  53. Byrge N, Barton RG, Ennis TM, Nirula R. Laparoscopic versus open repair of perforated gastroduodenal ulcer: a Nationl Surgical Quality Improvement Program analysis. Am J Surg Dec. 2013;206(6):957-962. discussion 962-963. Epub 2013 Oct 8. https://doi.org/10.1016/j.amjsurg.2013.08.014
  54. Lau H. Laparoscopic repair of perforated peptic ulcer: a meta-analysis. Surg Endosc. 2004;18:1013-1021.
  55. Lunevicius R, Morkevicius M. Management strategies, early results, benefits, and risk factors of laparoscopic repair of perforated peptic ulcer. World J Surg. 2005;29:1299-1310.
  56. Lunevicius R, Morkevicius M. Risk factors influencing the early outcome results after laparoscopic repair of perforated duodenal ulcer and their predictive value. Langenbecks Arch Surg. 2005;390:413-420.
  57. Kirshtein B, Byrne M, Mayer T, Lantsberg L, Avinoach E, Mizrahi S. Laparoscopic treatment og gastroduodenal peforations: comparison with conventional surgery. Surg Endosc. 2005;19:1487-1490.
  58. Siu W, Leong H, Law B, Chau CH, Li AC, Fung KH, Tai YP, Li MK. Laparoscopic repair for perforated peptic ulcer: a randomized controlled trial. Ann Surg. 2002;235:313-319.
  59. Bertleff MJ, Lange JF. Laparoscopic correction of perforated peptic ulcer: first choice? A review of literature. Surg Endosc. 2010;24(6):1231-1239.
  60. Naesgaard JM, Edwin B, Reiertsen O, Trondsen E, Faerden AE, Rosseland AR. Laparoscopic and open operation in patients with perforated pepticulcer. Eur J Surg. 1999;165:209-214.
  61. Evasovich MR, Clark TC, Horattas MC, Holda S, Treen L. Does pneumoperitoneum during laparoscopy increase bacterial translocation? Surg Endosc. 1996;10:1176-1179.
  62. Gurtner GC, Robertson CS, Chung SC, Ling TK, Ip SM, Li AK. Effect of carbon dioxide pneumoperitoneum on bacteraemia and endotoxaemia in an animal model of peritonitis. Br J Surg. 1995;82:844-848.
  63. Robertson GS, Wemyss-Holden SA, Maddern GJ: Laparoscopic repair of perforated duodenal ulcers. The role of laparoscopy in generalized peritonitis. Ann R Coll Surg Engl. 2000;82:6-10.
  64. Schietroma M, Piccione F, Carlei F, Sista F, Cecilia EM, Amicucci G. Peritonitis from perforated peptic ulcer and immune response. J Invest Surg. 2013;26(5):294-304. https://doi.org/10.3109/08941939.2012.762073
  65. Lau WY, Leung KL, Zhu XL, Lam YH, Chung SC, Li AK. laparoscopic repair of perforated peptic ulcer. Br J Surg. 1995;82:814-816.
  66. Guadagni S, Cengeli I, Galatioto C, Furbetta N, Piero VL, Zocco G, Seccia M. Laparoscopic repair of perforated peptic ulcer: single-center result. Surg Endosc. 2014;28(8):2302-2308. https://doi.org/10.1007/s00464-014-3481-2
  67. Vaidya BB, Garg CP, Shah JB. Laparoscopic Repair of Perforated Peptic Ulcer with Delayed Presentation. J Laparoendosc Adv Surg Tech A. 2009;19(2):153-156. https://doi.org/10.1089/lap.2008.0328
  68. Bertleff MJ, Halm JA, Bemelman WA, van der Ham AC, van der Harst E, Oei HI, Smulders JF, Steyerberg EW, Lange JF. Randomized Clinical Trial of Laparoscopic Versus Open Repair of the Perforated Peptic Ulcer: The LAMA Trial. World J Surg. 2009;33(7):1368-1373. https://doi.org/10.1007/s00268-009-0054-y
  69. Flore V, Beuran M, Lica I, Turculet C, Cotarlet AV, Georgescu S, Vintila D. Laparoscopic Repair for Perforated Peptic Ulcer: A Retrospective Study. World J Surg. 2017;41(4):948-953. https://doi.org/10.1007/s00268-016-3821-6

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.