Material and methods. This prospective cohort study included the results of treatment of 68 patients who underwent laparoscopic sleeve gastroplasty in 2011—2014 in the Road Hospital. Among the patients there were 47 women and 21 men aged 18 to 56 years, with a BMI of 35 to 64. Before the surgery, to all patients underwent endoscopic examination of the upper and lower digestive tract, ultrasound examination of the abdominal cavity organs, radiography of the skull, electro- and echocardiography, the function of external respiration was determined, hormonal status was investigated, general clinical laboratory tests were performed. Results. The volume of intraoperative blood loss did not exceed 50—100 ml, the duration of the operation was 45—140 min (on average 75 min). There were no conversions. Intraoperative complications were observed in 7% of cases. In the long-term period, positive results of body mass dynamics were observed in 59 patients (86.76%). Abnormal eating disorders were noted in all patients with unsatisfactory results. Conclusions. Sleeve gastroplasty with the gastric tube staging is a safe and effective intervention in patients with morbid obesity and allows satisfactory results in 87% of cases. The proposed technique for the formation of a three-chamber stomach is physiologically optimal in the presence of GER before surgery and allows to reduce the phenomena of postoperative GER up to 10%.