Predictive value of laboratory markers in identifying postoperative complications among Crohn’s disease patients

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OBJECTIVE

This study aims to identify associations between laboratory markers, clinical indicators, and the development of postoperative complications in CD patients.

MATERIAL AND METHODS

A retrospective study included 139 CD patients who underwent surgery at the Coloproctology Department of the A.S. Loginov Medical Research Center between 2015 and 2022. Hemoglobin levels, albumin levels, and C-reactive protein (CRP) concentrations were assessed. Patients were categorized into two groups: Group 1 comprised individuals without deviations or with a single deviation from reference values, while Group 2 included those with two or three deviations. The frequency of postoperative complications within the first 30 days after surgery was analyzed in both groups.

RESULTS

The overall incidence of postoperative complications was significantly higher in Group 2 (57.1% vs. 13.4%, p<0.001). Specifically, rates of wound infection (20% vs. 4.8%, p=0.006), intra-abdominal abscess formation (20% vs. 2.8%, p<0.001), and stoma creation (8.5% vs. 0%, p=0.003) were notably elevated in this group.

CONCLUSIONS

The findings underscore the importance of preoperative evaluation and risk stratification based on hemoglobin, albumin, and CRP levels in CD patients.

Keywords:

inflammatory bowel disease

Crohn’s disease

surgical intervention

risk stratification

postoperative complications

Authors:

Danilov M.A.

A.S. Loginov Moscow Clinical Scientific Center Department of Health of Moscow

ORCID: 0000-0001-9439-9873

Demidova A.A.

A.S. Loginov Moscow Clinical Scientific Center Department of Health of Moscow

ORCID: 0000-0001-5141-1692

Knyazev O.V.

Clinical Research Center of Moscow

ORCID: 0000-0001-7250-0977

Kagramanov A.V.

Clinical Research Center of Moscow

ORCID: 0000-0002-3818-6205

Received:

25.05.2023

Accepted:

30.07.2023

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