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Danilov M.A.

A.S. Loginov Moscow Clinical Scientific Center Department of Health of Moscow

Demidova A.A.

A.S. Loginov Moscow Clinical Scientific Center Department of Health of Moscow

Knyazev O.V.

Clinical Research Center of Moscow

Kagramanov A.V.

Clinical Research Center of Moscow

Predictive value of laboratory markers in identifying postoperative complications among Crohn’s disease patients

Authors:

Danilov M.A., Demidova A.A., Knyazev O.V., Kagramanov A.V.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2023;12(3): 24‑28

DOI: 10.17116/dokgastro20231203124

Read: 1590 times

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Table of contents

PREDICTIVE VALUE OF LABORATORY MARKERS IN IDENTIFYING POSTOPERATIVE COMPLICATIONS AMONG CROHN’S DISEASE PATIENTS
PREDICTIVE VALUE OF LABORATORY MARKERS IN IDENTIFYING POSTOPERATIVE COMPLICATIONS AMONG CROHN’S DISEASE PATIENTS

To cite this article:

Danilov MA, Demidova AA, Knyazev OV, Kagramanov AV. Predictive value of laboratory markers in identifying postoperative complications among Crohn’s disease patients. Russian Journal of Evidence-Based Gastroenterology. 2023;12(3):24‑28. (In Russ.)
https://doi.org/10.17116/dokgastro20231203124

Подписка 2026 Доказательная гастроэнтерология (Russian Journal of Evidence-Based Gastroenterology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Approximately 50% of patients with Crohn’s disease (CD) require surgical intervention at some point in their lives. The frequency of postoperative complications is higher among CD patients compared to those undergoing surgery for other reasons, primarily due to the use of immunosuppressive and biological agents. Numerous factors influence the risk of complications, underscoring the need for careful consideration before planning surgical interventions.

OBJECTIVE

This study aims to identify associations between laboratory markers, clinical indicators, and the development of postoperative complications in CD patients.

MATERIAL AND METHODS

A retrospective study included 139 CD patients who underwent surgery at the Coloproctology Department of the A.S. Loginov Medical Research Center between 2015 and 2022. Hemoglobin levels, albumin levels, and C-reactive protein (CRP) concentrations were assessed. Patients were categorized into two groups: Group 1 comprised individuals without deviations or with a single deviation from reference values, while Group 2 included those with two or three deviations. The frequency of postoperative complications within the first 30 days after surgery was analyzed in both groups.

RESULTS

The overall incidence of postoperative complications was significantly higher in Group 2 (57.1% vs. 13.4%, p<0.001). Specifically, rates of wound infection (20% vs. 4.8%, p=0.006), intra-abdominal abscess formation (20% vs. 2.8%, p<0.001), and stoma creation (8.5% vs. 0%, p=0.003) were notably elevated in this group.

CONCLUSIONS

The findings underscore the importance of preoperative evaluation and risk stratification based on hemoglobin, albumin, and CRP levels in CD patients.

Keywords:

inflammatory bowel disease
Crohn’s disease
surgical intervention
risk stratification
postoperative complications

Authors:

Danilov M.A.

A.S. Loginov Moscow Clinical Scientific Center Department of Health of Moscow

Demidova A.A.

A.S. Loginov Moscow Clinical Scientific Center Department of Health of Moscow

Knyazev O.V.

Clinical Research Center of Moscow

Kagramanov A.V.

Clinical Research Center of Moscow

Received:

25.05.2023

Accepted:

30.07.2023

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