The predictive value of intestinal α4β7 integrin gene polymorphism in patients with ulcerative colitis

Zhilin I.V.

Irkutsk Scientific Centre of Surgery and Traumatology;
Chita State Medical Academy

Chashkova E.Yu.

Irkutsk Scientific Centre of Surgery and Traumatology

Zhilina A.A.

Chita State Medical Academy

Markovskiy A.V.

Chita State Medical Academy

The predictive value of intestinal α4β7 integrin gene polymorphism in patients with ulcerative colitis

Authors:

Zhilin I.V., Chashkova E.Yu., Zhilina A.A., Markovskiy A.V.

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Journal: Russian Journal of Evidence-Based Gastroenterology. 2021;10(3): 15‑20

DOI: 10.17116/dokgastro20211003115

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To cite this article:

Zhilin IV, Chashkova EYu, Zhilina AA, Markovskiy AV. The predictive value of intestinal α4β7 integrin gene polymorphism in patients with ulcerative colitis. Russian Journal of Evidence-Based Gastroenterology. 2021;10(3):15‑20. (In Russ.)
https://doi.org/10.17116/dokgastro20211003115

Подписка 2025 (Russian Journal of Evidence-Based Gastroenterology)

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OBJECTIVE

We assessed genes ITGA4 (rs1143674; rs1449263) and ITGB7 (rs11574532) polymorphisms as possible predictors for surgical treatment in patients with ulcerative colitis (UC).

MATERIAL AND METHODS

A retrospective study from 2017 to 2020 included 86 patients (27 — the surgical treatment group; 59 — the conservative treatment group) and 115 healthy volunteers (control group) born and living in the Irkutsk region and the Trans-Baikal Territory. Genotypes were studied by the polymerase chain reaction in real-time. The χ² test, odds ratio, and binary logistic regression analysis were used for statistical analysis in the IBM SPSS Statistics Version 25.0 program.

RESULTS

Homozygotes GG ITGA4 (rs1449263) in the conservative treatment group were found 2.6 times more often than in control group (p=0.017; OR=2.663 CI 95%; 1.164—6.090), the distribution frequency of ITGA4 (rs1143674) and ITGB7 (rs11574532) did not differ in these groups (p>0.05). In patients heterozygous for the ITGA4 (rs1449263) AG gene, indications for surgery were found 3.4 times more often than in homozygous patients (p=0.026; OR=3.4; 95% CI: 1.113—10 582). Carriers of ITGB7 (rs11574532) TT were found only in the surgical treatment group (p=0.018). In patients with proctitis, there were no indications for coloproctectomy (p=0.037), with pancolitis, the chances of surgery increased 6.7 times (p=0.007; OR=6.7; 95% CI; 1.454—30.577). Regression logistic analysis revealed that ITGB7 (rs11574532) (p=0.04; 95% CI 1.037—11.162) and UC oncet age (p=0.009; 95% CI: 1.581—23.437) were predictors of the coloproctectomy, which were included into the logistic regression equation.

CONCLUSION

Polymorphisms ITGA4 (rs1449263) AG, ITGB7 (rs11574532) TT combined with factors as early onset of UC and pancolitis are predictors of coloproctectomy. According to the ROC-curve data, the developed model has a good predictive power (AUC=0.807, 95% CI 0.729—0.886, p<0.001; standard error 0.04).

Keywords:

ulcerative colitis

coloproctectomy

integrin

coloproctectomy predictors

ITGA4 (rs1143674)

ITGA4 (rs1449263)

ITGB7 (rs11574532)

Authors:

Zhilin I.V.

Irkutsk Scientific Centre of Surgery and Traumatology;
Chita State Medical Academy

Chashkova E.Yu.

Irkutsk Scientific Centre of Surgery and Traumatology

Zhilina A.A.

Chita State Medical Academy

Markovskiy A.V.

Chita State Medical Academy

Received:

22.08.2021

Accepted:

07.09.2021

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