Aim. The objective of the present work was to study the prevalence of gastroesophageal reflux disease and to evaluate the influence of this condition on the quality of life of the patients suffering from migraine. Material and methods. A total of 104 patients suffering from migraine were available for the examination. The age of the patients varied from 18 to 60 years. Special emphasis was placed on the detection of heartburn and evaluation of its severity during the ictal and interictal periods of migraine. All the patients underwent oesophagoduodenoscopy. The health-related quality of life was estimated with the use of the MOS SF-36 questionnaire. Results. Heartburn in the absence of migrainous attacks was shown to occur in 48 (46.%) patients while gastroesophageal reflux disease was diagnosed in 57 (54.8%) of them. The patients presenting with the combined pathology were significantly older and had a higher body mass index than the remaining ones. They showed a tendency toward increasingly frequent migrainous attacks, more intense headache, and a higher degree of dysadaptation. The correlation analysis revealed the relationship between the occurrence of heartburn in the absence of migrainous events, its intensity during painful migrainous attacks, and the frequency of migrainous events. All characteristics of the quality of life (with the exception of bodily pain} were lower in the group of patients presenting with the combined pathology compared with the remaining ones. Conclusion. The study has demonstrated that both heartburn and gastroesophageal reflux disease are widespread among the patients suffering from migraine and tend to occur more frequently in the patients presenting with chronic cephalgia. The quality of life in the patients with the combined pathology is significantly lower than in those suffering from migraine alone.