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Guscha A.O.

Moscow Multidisciplinary Clinical Center “Kommunarka”, Moscow, Russia

Avdalyan A.M.

Moscow Multidisciplinary Clinical Center “Kommunarka”, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Sapozhnikova R.I.

Moscow Multidisciplinary Clinical Center “Kommunarka”, Moscow, Russia

Savelov N.A.

Moscow City Oncology Hospital No. 62, Moscow, Russia

Demidova I.A.

Moscow City Oncology Hospital No. 62, Moscow, Russia

Spontaneous regression of colorectal cancer liver metastasis

Authors:

Guscha A.O., Avdalyan A.M., Sapozhnikova R.I., Savelov N.A., Demidova I.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2026;88(3): 66‑72

DOI: 10.17116/patol20268803166

Read: 370 times

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Table of contents

SPONTANEOUS REGRESSION OF COLORECTAL CANCER LIVER METASTASIS
SPONTANEOUS REGRESSION OF COLORECTAL CANCER LIVER METASTASIS

To cite this article:

Guscha AO, Avdalyan AM, Sapozhnikova RI, Savelov NA, Demidova IA. Spontaneous regression of colorectal cancer liver metastasis. Russian Journal of Archive of Pathology. 2026;88(3):66‑72. (In Russ.)
https://doi.org/10.17116/patol20268803166

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The mechanism of spontaneous regression of metastatic colorectal carcinoma in the liver remains incompletely understood. This article describes a case of spontaneous tumor regression in a metastatic lesion of colorectal cancer with microsatellite instability. An immune response to the neoantigen-rich tumor may have contributed to the spontaneous regression of the metastasis.

Keywords:

spontaneous regression
colorectal cancer
microsatellite instability
liver metastasis

Authors:

Guscha A.O.

Moscow Multidisciplinary Clinical Center “Kommunarka”, Moscow, Russia

Avdalyan A.M.

Moscow Multidisciplinary Clinical Center “Kommunarka”, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Sapozhnikova R.I.

Moscow Multidisciplinary Clinical Center “Kommunarka”, Moscow, Russia

Savelov N.A.

Moscow City Oncology Hospital No. 62, Moscow, Russia

Demidova I.A.

Moscow City Oncology Hospital No. 62, Moscow, Russia

Received:

08.08.2025

Accepted:

16.02.2026

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References:

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  2. Papac RJ. Spontaneous regression of cancer. Cancer Treatment Reviews. 1996;22(6):395-423.  https://doi.org/10.1016/S0305-7372(96)90023-7
  3. Abdelrazeq AS. Spontaneous regression of colorectal cancer: a review of cases from 1900 to 2005. International Journal of Colorectal Disease. 2007;22(7):727-736.  https://doi.org/10.1007/s00384-006-0245-z
  4. Mizushima N. Autophagy: process and function. Genes & Development. 2007;21(22):2861-2873. https://doi.org/10.1101/gad.1599207
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  6. Kloor M, von Knebel Doeberitz M. The immune biology of microsatellite-unstable cancer. Trends Cancer. 2016;2(3):121-133.  https://doi.org/10.1016/j.trecan.2016.02.004
  7. Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA, Kinzler KW. Cancer genome landscapes. Science. 2013;339(6127): 1546-1558. https://doi.org/10.1126/science.1235122
  8. Waldman AD, Fritz JM, Lenardo MJ. A guide to cancer immunotherapy: from T cell basic science to clinical practice. Nature Reviews. Immunology. 2020;20(11):651-668.  https://doi.org/10.1038/s41577-020-0306-5
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