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Frank G.A.

Russian Medical Academy of Continuous Professional Education

Avdalyan A.M.

Moscow Multidisciplinary Clinical Center “Kommunarka”;
Russian University of Medicine

Telezhnikova I.M.

Moscow Multidisciplinary Clinical Center “Kommunarka”;
Vladimirsky Moscow Regional Clinical Research Institute

Classification of non-small cell lung cancer according to the WHO 2021: from morphology to personalized therapy

Authors:

Frank G.A., Avdalyan A.M., Telezhnikova I.M.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2026;87(1): 60‑67

DOI: 10.17116/patol20268801160

Read: 1201 times

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Table of contents

CLASSIFICATION OF NON-SMALL CELL LUNG CANCER ACCORDING TO THE WHO 2021: FROM MORPHOLOGY TO PERSONALIZED THERAPY
CLASSIFICATION OF NON-SMALL CELL LUNG CANCER ACCORDING TO THE WHO 2021: FROM MORPHOLOGY TO PERSONALIZED THERAPY

To cite this article:

Frank GA, Avdalyan AM, Telezhnikova IM. Classification of non-small cell lung cancer according to the WHO 2021: from morphology to personalized therapy. Russian Journal of Archive of Pathology. 2026;87(1):60‑67. (In Russ.)
https://doi.org/10.17116/patol20268801160

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This study analyzes the modern (2021) WHO classification of lung tumors and reviews publications in Russian and English from databases including PubMed, Google Scholar, ClinicalTrials.gov, eLibrary, and CyberLeninka. The aim of this review is to identify key changes in the 2021 WHO classification compared to the 2015 edition and assess their significance for the diagnosis and personalized treatment of non-small cell lung cancer. Special attention is given to the handling of small biopsy specimens, which requires an integrated approach involving morphological examination, immunohistochemistry, and molecular genetic testing.

Keywords:

non-small cell lung cancer
WHO classification
immunohistochemistry
molecular genetic testing
biomarkers
targeted therapy
personalized medicine

Authors:

Frank G.A.

Russian Medical Academy of Continuous Professional Education

Avdalyan A.M.

Moscow Multidisciplinary Clinical Center “Kommunarka”;
Russian University of Medicine

Telezhnikova I.M.

Moscow Multidisciplinary Clinical Center “Kommunarka”;
Vladimirsky Moscow Regional Clinical Research Institute

Accepted:

22.06.2025

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