Expression of markers of epithelial-mesenchymal transition in breast cancer

Studenikina A.A.

Novosibirsk State Medical University;
Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0003-3936-1316

Arkhipov S.A.

Novosibirsk State Medical University;
Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0002-1390-4426

Zhurakovsky I.P.

Novosibirsk State Medical University;
Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0003-0496-9401

Proskura A.V.

Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0003-2313-1591

Autenshlyus A.I.

Novosibirsk State Medical University;
Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0001-7180-010X

Expression of markers of epithelial-mesenchymal transition in breast cancer

Authors:

Studenikina A.A., Arkhipov S.A., Zhurakovsky I.P., Proskura A.V., Autenshlyus A.I.

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Journal: Russian Journal of Archive of Pathology. 2023;85(4): 12‑17

DOI: 10.17116/patol20238504112

Downloaded: 70

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To cite this article:

Studenikina AA, Arkhipov SA, Zhurakovsky IP, Proskura AV, Autenshlyus AI. Expression of markers of epithelial-mesenchymal transition in breast cancer. Russian Journal of Archive of Pathology. 2023;85(4):12‑17. (In Russ.)
https://doi.org/10.17116/patol20238504112

Подписка 2025-2 (Russian Journal of Archive of Pathology)

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OBJECTIVE

To study of the expression of epithelial-mesenchymal transition markers in various molecular subtypes of cancer and in benign breast diseases with different risks of malignant transformation.

MATERIAL AND METHODS

An immunohistochemical study of the expression of E-cadherin, collagen II, integrin 1β, cyclin D1 was carried out in breast tissue samples: 58 with invasive breast carcinoma of no special type and 17 with benign breast diseases with a high and low risk of malignant transformation.

RESULTS

Patients with a triple negative molecular subtype are characterized by lower expression of collagen II compared with individuals with luminal A and B+ subtypes. A distinctive feature of patients with the HER2+ subtype was increased expression of cyclin D1 compared with the luminal A subtype, and in patients with the luminal B+ subtype, the expression of integrin 1β is higher than in the luminal B- and HER2+ subtypes. The expression of cyclin D1 in patients of both groups with benign diseases was lower than in all groups with invasive carcinoma, but at the same time, in patients with a low risk of malignant transformation, the expression of cyclin D1 was higher than in those with an increased risk.

CONCLUSION

The study revealed the relationship between the expression of markers and molecular subtypes of breast tumors, in addition, some patients with benign diseases were found who need further more careful monitoring and may be at risk for the development of malignancy.

Keywords:

breast cancer

molecular subtypes

benign breast diseases

epithelial-mesenchymal transition

Authors:

Studenikina A.A.

Novosibirsk State Medical University;
Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0003-3936-1316

Arkhipov S.A.

Novosibirsk State Medical University;
Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0002-1390-4426

Zhurakovsky I.P.

Novosibirsk State Medical University;
Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0003-0496-9401

Proskura A.V.

Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0003-2313-1591

Autenshlyus A.I.

Novosibirsk State Medical University;
Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine

ORCID: 0000-0001-7180-010X

Received:

24.12.2022

Accepted:

19.04.2023

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