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Popova O.P.
A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of Russia;
Treatment and Rehabilitation Center of the Ministry of Health of Russia
Kuznetsova A.V.
A.I. Evdokimov Moscow State University of Medicine and Dentistry;
N.K. Koltsov Institute of Developmental Biology
Bogomazova S.Yu.
Treatment and Rehabilitation Center of the Ministry of Health of Russia
Ivanov A.A.
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Is there a claudin-low phenotype of breast cancer?
Journal: Russian Journal of Archive of Pathology. 2022;84(1): 45‑49
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To cite this article:
Popova OP, Kuznetsova AV, Bogomazova SYu, Ivanov AA. Is there a claudin-low phenotype of breast cancer?. Russian Journal of Archive of Pathology.
2022;84(1):45‑49. (In Russ.)
https://doi.org/10.17116/patol20228401145
The novel molecular subtype of breast cancer (BC), named “claudin-low”, was described in 2007. It was characterized by the consistently low expression of genes involved in the formation of epithelial tight junctions in combination with the high activation of genes associated with the epithelial-to-mesenchymal transition, as well as tumor stem cell markers. The similar claudin- low subtype was later identified at the transcriptional level in bladder cancer, gastric cancer, and serous ovarian cancer. However, only in relation to BC, attempts were made to create a surrogate panel for immunohistochemical identification of this subtype in a manner like the intrinsic molecular BC subtypes identified using three main markers, such as ER, PR, and HER-2. At the same time, the ambiguity in the expression of claudins among the subtypes of BC, which is defined by various authors at the immunohistochemical level, as well as the absence of both the confirmed set of immunohistochemical criteria and a unified approach to their assessment, complicate these efforts. The purpose of the review is to show that the immunohistochemical identification of claudin-low subtype of BC is a separate problem that has significant limitations, needs standardization and has not yet reached diagnostic value.
Authors:
Popova O.P.
A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of Russia;
Treatment and Rehabilitation Center of the Ministry of Health of Russia
Kuznetsova A.V.
A.I. Evdokimov Moscow State University of Medicine and Dentistry;
N.K. Koltsov Institute of Developmental Biology
Bogomazova S.Yu.
Treatment and Rehabilitation Center of the Ministry of Health of Russia
Ivanov A.A.
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Received:
24.09.2021
Accepted:
10.11.2021
List of references:
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