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Prikhodko V.A.

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation

Selizarova N.O.

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation

Okovityĭ S.V.

Saint-Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of Russia

Molecular mechanisms for hypoxia development and adaptation to it. Part I

Authors:

Prikhodko V.A., Selizarova N.O., Okovityĭ S.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2021;83(2): 52‑61

DOI: 10.17116/patol20218302152

Read: 15199 times

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MOLECULAR MECHANISMS FOR HYPOXIA DEVELOPMENT AND ADAPTATION TO IT. PART I
MOLECULAR MECHANISMS FOR HYPOXIA DEVELOPMENT AND ADAPTATION TO IT. PART I

To cite this article:

Prikhodko VA, Selizarova NO, Okovityĭ SV. Molecular mechanisms for hypoxia development and adaptation to it. Part I. Russian Journal of Archive of Pathology. 2021;83(2):52‑61. (In Russ.)
https://doi.org/10.17116/patol20218302152

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Hypoxia is a typical pathological process characterized by the occurrence of oxygen deficiency in tissues and cells and accompanied by the development of immediate and delayed compensatory and adaptive reactions. Reprogramming of the mitochondrial electron transport chain (ETC) function is one the most essential regulatory mechanisms that allow for immediate adaptation to hypoxia. Succinic acid, or succinate, is involved in this process not only as one of the intermediates of the tricarboxylic acid (TAC) cycle, but also as a signaling molecule. In this connection, the purpose of this review was to systematize the available data on the molecular mechanisms for the development of hypoxia and its adaptation at the ETC/TAC coupling site, as well as on the role of succinic acid in these processes.

Keywords:

hypoxia
succinate
succinic acid
mitochondrial signaling
antihypoxants

Authors:

Prikhodko V.A.

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation

Selizarova N.O.

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation

Okovityĭ S.V.

Saint-Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of Russia

Received:

18.01.2021

Accepted:

21.01.2021

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