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Byakhova M.M.

Moscow Regional Clinical Research Institute named after M.F. Vladimirsky, Moscow, Russia;
Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Andreeva Yu.Yu.

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Tyulyandin S.A.

National Medical Research Center for Oncology named after N. N. Blokhin, Moscow, Russia

Timofeev I.V.

S.M. Kirov Military Medical Academy, Saint Petersburg, Russian Federation

Imianitov E.N.

NII onkologii im. N.N. Petrova, Sankt-Peterburg

Demidova I.A.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN", Moskva;
FGBU "Moskovskiĭ NII pediatrii i detskoĭ khirurgii Minzdrava Rossii", Moskva;
Moskovskiĭ gorodskoĭ psikhologo-pedagogicheskiĭ universitet, Moskva

Kekeeva T.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Mueva N.M.

Aston Consulting JSC, Moscow, Russia

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Epidemiology and diagnosis of mutations in the ALK gene in patients with non-small cell lung cancer in the Moscow region

Authors:

Byakhova M.M., Zavalishina L.É., Andreeva Yu.Yu., Tyulyandin S.A., Timofeev I.V., Imianitov E.N., Demidova I.A., Kekeeva T.V., Mueva N.M., Frank G.A.

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Journal: Russian Journal of Archive of Pathology. 2020;82(3): 18‑23

DOI: 10.17116/patol20208203118

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Table of contents

EPIDEMIOLOGY AND DIAGNOSIS OF MUTATIONS IN THE ALK GENE IN PATIENTS WITH NON-SMALL CELL LUNG CANCER IN THE MOSCOW REGION
EPIDEMIOLOGY AND DIAGNOSIS OF MUTATIONS IN THE ALK GENE IN PATIENTS WITH NON-SMALL CELL LUNG CANCER IN THE MOSCOW REGION

To cite this article:

Byakhova MM, Zavalishina LÉ, Andreeva YuYu, et al. . Epidemiology and diagnosis of mutations in the ALK gene in patients with non-small cell lung cancer in the Moscow region. Russian Journal of Archive of Pathology. 2020;82(3):18‑23. (In Russ.)
https://doi.org/10.17116/patol20208203118

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Aim of study — to determine a diagnostic algorithm for detecting translocation of the ALK gene and its frequency in the Moscow region. Materials and methods. During the priod between 2014 and 2018 (inclusive), 488 patients without activating mutations in the EGFR gene in the Moscow region were tested. To detect translocation of the ALK gene, fluorescence in situ hybridization (FISH) methods, an immunohistochemical method, and, in some cases, a polymerase chain reaction were used. Results. Revealed ALK gene rearrangement in a population of patients with lung adenocarcinoma amounted to an average of 7.6% of cases. With this, the main method that we used was immunohistochemical method, applicable in more than 80% of cases. The use of other methods for verification of abnormalities in the ALK gene was found necessary in rare cases (3.3%). Conclusions. Using the algorithm presented in the article, it was possible to detect ALK gene rearrangement in a population of patients with lung adenocarcinoma in the Moscow region in an average of 7.6% of cases.

Keywords:

ALK gene
lung cancer
lung adenocarcinoma
ALK gene translocation

Authors:

Byakhova M.M.

Moscow Regional Clinical Research Institute named after M.F. Vladimirsky, Moscow, Russia;
Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Andreeva Yu.Yu.

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Tyulyandin S.A.

National Medical Research Center for Oncology named after N. N. Blokhin, Moscow, Russia

Timofeev I.V.

S.M. Kirov Military Medical Academy, Saint Petersburg, Russian Federation

Imianitov E.N.

NII onkologii im. N.N. Petrova, Sankt-Peterburg

Demidova I.A.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN", Moskva;
FGBU "Moskovskiĭ NII pediatrii i detskoĭ khirurgii Minzdrava Rossii", Moskva;
Moskovskiĭ gorodskoĭ psikhologo-pedagogicheskiĭ universitet, Moskva

Kekeeva T.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Mueva N.M.

Aston Consulting JSC, Moscow, Russia

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Close metadata

References:

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