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Ivina A.A.

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

Semkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

Rabinovich O.F.

Otdelenie patologii slizistoĭ obolochki rta FGBU TsNIIS i ChLKh Minzdrava Rossii, Moskva

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

To the question of proliferative verrucous leukoplakia malignant potential

Authors:

Ivina A.A., Semkin V.A., Rabinovich O.F., Babichenko I.I.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2020;82(3): 13‑17

DOI: 10.17116/patol20208203113

Read: 4937 times

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Table of contents

TO THE QUESTION OF PROLIFERATIVE VERRUCOUS LEUKOPLAKIA MALIGNANT POTENTIAL
TO THE QUESTION OF PROLIFERATIVE VERRUCOUS LEUKOPLAKIA MALIGNANT POTENTIAL

To cite this article:

Ivina AA, Semkin VA, Rabinovich OF, Babichenko II. To the question of proliferative verrucous leukoplakia malignant potential. Russian Journal of Archive of Pathology. 2020;82(3):13‑17. (In Russ.)
https://doi.org/10.17116/patol20208203113

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Aim of study — to study of neoplastic transformation of the epithelial cells of the oral mucosa with verrucous hyperortokeratosis, verrucous carcinoma and oral squamous cell carcinoma (OSCC). Materials and methods. Oral mucous membrane biopsies of 33 patients with clinical diagnosis of proliferative verrucous leukoplakia were investigated. Histologically in 19 cases (57.6%) was revealed verrucous hyperorthokeratosis, in 8 cases (24.2%) — verrucous carcinoma and in 6 cases (18.2%) — oral squamous cell carcinoma. Tissue antigens were determined using mouse monoclonal antibodies to Ki-67 and mouse monoclonal antibodies to cytokeratin 15. Results of the study. In comparison with the proliferative activity of epithelial cells in the malpighian layer in verrucous hyperorthokeratosis (17.2±8.1%) was detected increasingof cell proliferation in epithelial growth zone in verrucous carcinoma (33.8±8.1%) and in peripheral zone of solid areas in oral squamous cell carcinoma (51.2±35.7%). A significant decrease in the expression of cytokeratin 15 in the cytoplasm of tumor cells was noted inverrucous carcinoma and oral squamous cell carcinoma in comparison with verrucous hyperorthokeratosis. Conclusion. The obtained results proclaim that there is no stage of epithelial dysplasia during tumor transformation of proliferative verrucous leukoplakia into verrucous carcinoma and oral squamous cell carcinoma. Verrucous carcinoma by the nature of proliferative activity, cell atypia and expression of cytokeratin 15 corresponds to carcinoma in situ.

Keywords:

immunohistochemical study
proliferative verrucous leukoplakia
verrucous carcinoma
oral squamous cell carcinoma
Ki-67 and CK15

Authors:

Ivina A.A.

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

Semkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

Rabinovich O.F.

Otdelenie patologii slizistoĭ obolochki rta FGBU TsNIIS i ChLKh Minzdrava Rossii, Moskva

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

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References:

  1. EI-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, eds. WHO classification of head and neck tumours. 4th ed. Lyon: IARC; 2017.
  2. Upadhyaya JD, Fitzpatrick SG, Islam MNA, Bhattacharyya I, Cohen DM. A retrospective 20-year analysis of proliferative verrucous leukoplakia and its progression to malignancy and association with high-risk human papillomavirus. Head Neck Pathol. 2018;12(4): 500-510. https://doi.org/10.1007/s12105-018-0893-7
  3. Thennavan A, Byatnal AA, Solomon MC, Radhakrishnan RA. The role of Ki-67, p16, CD34, Bcl-2, cyclooxygenase-2in the pathogenesis of proliferative verrucous leukoplakia. Indian J Cancer. 2015;52(4):498-502. https://doi.org/10.4103/0019-509X.178424
  4. Rintala M, Vahlberg T, Salo T, Rautava J. Proliferative verrucous leukoplakia and its tumour markers: systematic review and meta-analysis. Head Neck. 2019;41(5):1499-1507. https://doi.org/10.1002/hed.25569
  5. Villa A, Menon RS, Kerr AR, De Abreu Alves F, Guollo A, Ojeda D, Woo SB. Proliferative leukoplakia: proposed new clinical diagnostic criteria. Oral Dis. 2018;24(5):749-760. https://doi.org/10.1111/odi.12830
  6. Müller S. Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(6):591-602. https://doi.org/10.1016/j.oooo.2018.02.012
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  9. Ivina AA, Semkin VA, Babichenko II. Cytokeratin 15 as a diagnostic marker for oral epithelial malignization. Stomatology/Stomatologiya. 2018;97(6):61-62. (In Russ). https://doi.org/10.17116/stomat20189706161
  10. Ivina AA, Syomkin VA, Babichenko II. Morphology of epithelial-mesenchymal transformation in neoplasias of oral mucosa. Stomatology/Stomatologiya. 2017;96(5):11-3. (In Russ). https://doi.org/10.17116/stomat201796511-13
  11. Mehrotra D, Goel M, Kumar S. Oral verrucous lesions: controversies in diagnosis and management. J Oral Biol Craniofac Res. 2012;2(3):163-169. https://doi.org/10.1016/j.jobcr.2012.10.006
  12. Speight PM. Update on oral epithelial dysplasia and progression to cancer. Head Neck Pathol. 2007;1(1):61-66. https://doi.org/10.1007/s12105-007-0014-5
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