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Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Kekeeva T.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Aleksakhina C.N.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Garifullina T.R.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Ivantsov O.A.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Mitiushkina N.V.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Pfaĭfer V.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Strelkova T.N.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Imianitov E.N.

NII onkologii im. N.N. Petrova, Sankt-Peterburg

First Russian nationwide molecular epidemiological study for melanoma: results of BRAF mutation analysis

Authors:

Frank G.A., Zavalishina L.É., Kekeeva T.V., Aleksakhina C.N., Garifullina T.R., Ivantsov O.A., Mitiushkina N.V., Pfaĭfer V., Strelkova T.N., Imianitov E.N.

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Journal: Russian Journal of Archive of Pathology. 2014;76(3): 65‑73

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To cite this article:

Frank GA, Zavalishina LÉ, Kekeeva TV, et al. . First Russian nationwide molecular epidemiological study for melanoma: results of BRAF mutation analysis. Russian Journal of Archive of Pathology. 2014;76(3):65‑73. (In Russ.)

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This report presents the initial results of the first Russian molecular epidemiological study of melanoma. The investigation included 1035 patients with stage IIIB-IV melanoma residing in various regions of Russia. Sequencing of BRAF gene revealed mutation in 627 (60.6%) tumors; c.1799T>A (p.V600E) substitution was detected in 563 cases, and other mutations in 64 melanomas. Frequency of BRAF alterations was significantly higher in patients of younger age (< 50 years: 72.9%; 50 years: 57.1%; p=0.00003). 710 melanomas included in the study were located in sun non-exposed regions of the skin; this category of tumors was characterized by the highest occurrence of BRAF mutations (63.9%). In conclusion, more than a half of Russian patients with advanced melanoma are potential candidates for the treatment of kinase inhibitors of mutated BRAF.

Keywords:

melanoma
molecular genetic study
mutations in the BRAF gene

Authors:

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Kekeeva T.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Aleksakhina C.N.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Garifullina T.R.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Ivantsov O.A.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Mitiushkina N.V.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Pfaĭfer V.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Strelkova T.N.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Imianitov E.N.

NII onkologii im. N.N. Petrova, Sankt-Peterburg

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