Specific features of gene amplification on the long arm of chromosome 17 in different molecular genetic subtypes of breast cancer

Zavalishina L.É.; Danilova N.V.; Matsionis A.É.; Pavlenko I.A.

doi:https://doi.org/

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Danilova N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Matsionis A.É.

GBU Rostovskoĭ oblasti "Patologoanatomicheskoe biuro", Rostov-na-Donu

Pavlenko I.A.

GBU Rostovskoĭ oblasti "Patologoanatomicheskoe biuro", Rostov-na-Donu

Specific features of gene amplification on the long arm of chromosome 17 in different molecular genetic subtypes of breast cancer

Authors:

Zavalishina L.É., Danilova N.V., Matsionis A.É., Pavlenko I.A.

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Journal: Russian Journal of Archive of Pathology. 2014;76(2): 8‑12

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To cite this article:

Zavalishina LÉ, Danilova NV, Matsionis AÉ, Pavlenko IA. Specific features of gene amplification on the long arm of chromosome 17 in different molecular genetic subtypes of breast cancer. Russian Journal of Archive of Pathology. 2014;76(2):8‑12. (In Russ.)

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

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Abstract:

The frequency of gene amplification and coamplification of Her2/neu, TOP2A and the centromeric region of chromosome 17 (CEP17) was examined in 265 breast cancer (BC) cases belonging to different molecular genetic subgroups. Luminal B breast cancer was found to be characterized by the increased probability of coamplifications (CEP17 and Her/neu, Her2/neu, and TOP2A) on chromosome 17. At the same time, the amplification of just three loci on one chromosome is a rare event and encountered in 17% of luminal B breast cancer cases (or 1.1% of all BC cases). That of Her2/neu in conjunction with elevated CEP17 count is statistically significantly more rarely accompanied by deletion of TOP2A rather than its amplification. The findings suggest that there are different amplification mechanisms in different BC molecular genetic subgroups.

Keywords:

gene amplification

chromosome 17

breast cancer

Authors:

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Danilova N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Matsionis A.É.

GBU Rostovskoĭ oblasti "Patologoanatomicheskoe biuro", Rostov-na-Donu

Pavlenko I.A.

GBU Rostovskoĭ oblasti "Patologoanatomicheskoe biuro", Rostov-na-Donu

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