The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Mikhaleva L.M.

Research Institute of Human Morphology, Moscow, Russia

Barkhina T.G.

FGBU "Nauchno-issledovatel'skiĭ institut morfologii cheloveka" RAMN

Shchegoleva N.N.

FGBU "Nauchno-issledovatel'skiĭ institut morfologii cheloveka" RAMN

Gracheva N.A.

FGBU "Nauchno-issledovatel'skiĭ institut morfologii cheloveka" RAMN

Golovanova V.E.

FGBU "Nauchno-issledovatel'skiĭ institut morfologii cheloveka" RAMN

Comparative morphology of the gastric mucosa in asthmatic patients using inhaled glucocorticosteroid therapy

Authors:

Mikhaleva L.M., Barkhina T.G., Shchegoleva N.N., Gracheva N.A., Golovanova V.E.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2013;75(2): 9‑15

Views: 1014

Downloaded: 42

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Mikhaleva LM, Barkhina TG, Shchegoleva NN, Gracheva NA, Golovanova VE. Comparative morphology of the gastric mucosa in asthmatic patients using inhaled glucocorticosteroid therapy. Russian Journal of Archive of Pathology. 2013;75(2):9‑15. (In Russ.)

Подписка 2025 (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Close metadata
Recommended articles:
Acute respiratory infe­ctions in pregnant women with respiratory diseases. Obstetric and peri­natal outcomes. Russian Bulletin of Obstetrician-Gynecologist. 2024;(1):76-82
Analytical review of respiratory infe­ctions role in patients with chro­nic obstructive pulmonary disease and asthma. Part 2. Prevention of occu­rrence and severe course of respiratory infe­ctions. Russian Journal of Preventive Medi­cine. 2024;(2):103-110
Therapeutic physical factors in correction of systemic mechanisms of como­rbidity in patients with poly­pous rhinosinusitis. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2024;(1):5-12
Clinical and epidemiological characteristics of bronchial asthma and chro­nic obstructive pulmonary disease inci­dence in Russia before and during the COVID-19 epidemy. Russian Journal of Preventive Medi­cine. 2024;(6):42-48
Features of the inflammatory process in the gastric mucosa with bacterial and viral co-infection. Russian Journal of Evidence-Based Gastroenterology. 2024;(3):13-19
Esophageal pathology and bronchial asthma: pathogenetic inte­ractions and possibilities for therapy opti­mization. Russian Journal of Preventive Medi­cine. 2024;(11):129-134

The immunomorphological characteristics of the gastric mucosa were evaluated and analyzed in patients with asthma of varying severity who received or did not receive inhaled or oral glucocorticosteroid therapy and in the control group. Immunohistological examination and morphometric analysis were used to study inflammatory infiltration in fundic mucosal biopsy specimens from patients with and without asthma. There were crucial immunomorphological differences between the examined patient groups and signs of the gastroprotective effect of inhaled glucocorticosteroids used in the basic therapy of asthma on the gastric mucosa. There was evidence that it is urgent to prevent erosive and atrophic gastritis and other inflammatory stomach diseases in asthma.

Keywords:

asthma
gastric mucosa
topical glucocorticosteroids

Authors:

Mikhaleva L.M.

Research Institute of Human Morphology, Moscow, Russia

Barkhina T.G.

FGBU "Nauchno-issledovatel'skiĭ institut morfologii cheloveka" RAMN

Shchegoleva N.N.

FGBU "Nauchno-issledovatel'skiĭ institut morfologii cheloveka" RAMN

Gracheva N.A.

FGBU "Nauchno-issledovatel'skiĭ institut morfologii cheloveka" RAMN

Golovanova V.E.

FGBU "Nauchno-issledovatel'skiĭ institut morfologii cheloveka" RAMN

List of references:

  1. Galimova E.S., Nurtdinova G.M., Kucher O.I., Boikova I.S., Khamitova I.A. Zabolevaniya organov pishchevareniya u bol'nykh bronkhial'noi astmoi. Fundamental'nye issledovaniya. 2010; 1: 36-40.
  2. Gembitskii E.V., Kirillov S.M., Kirillov M.M. i dr. Zabolevaniya pishchevaritel'noi sistemy u bol'nykh bronkhial'noi astmoi. Klinicheskaya meditsina. 2000; 3: 54-7.
  3. Kononov A.V., Nepomnyashchikh G.I., Zinov'ev A.S. Morfogenez khronicheskikh vospalitel'nykh zabolevanii dykhatel'noi i pishchevaritel'noi sistem. Byulleten' Sib. otd. AMN SSSR. 1988; 1: 75-82.
  4. Korabel'nikov D.N., Chuchalin A.G. Bronkhial'naya astma i soputstvuyushchie zabolevaniya organov pishchevareniya. Pul'monologiya. 2002; 5: 87-92.
  5. Charles W.D., Rothenberg M.E. Allergy and eosinophil-associated gastrointestinal disorders (EGID). Curr. Opin. Immunol. 2008; 20 (6): 703-8.
  6. Kirillov S.M., Kirillov M.M. Patologiya pishchevaritel'noi sistemy u bol'nykh bronkhial'noi astmoi: sravnitel'nyi analiz. Pul'monologiya. 2010; 5: 85-9.
  7. Shmatok M.I. Integral'naya otsenka razvitiya riska patologii gastroduodenal'noi zony u bol'nykh bronkhial'noi astmoi. Informatika i sistemy upravleniya. 2008; 2 (16): 184-5.
  8. Mikhaleva L.M., Barkhina T.G., Golovanova V.E., Shchegoleva N.N., Gracheva N.A., Ivanova E.V. Eozinofil'nyi ezofagit u patsienta s bronkhial'noi astmoi. Arkhiv patologii. 2012; 74 (4): 49-52.
  9. Nepomnyashchikh D.L., Lapii G.A., Aidagulova S.V., Bakarev M.A. Biopsiya v gastroenterologii: morfogenez obshchepatologicheskikh protsessov. M.: Izdatel'stvo RAMN; 2010: 197-233.
  10. Chernyavskaya G.M., Beloborodova E.I., Nepomnyashchikh G.I., Aidagulova S.V. Bronkhial'naya astma: porazheniya gastroduodenal'noi sistemy (klinicheskie, funktsional'nye i patomorfologicheskie aspekty). Tomsk: Pechatnaya manufaktura; 2004.
  11. Nair P., Ochkur S.I., Protheroe C., Simms E., Lee N.A., Lee J.J. The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma. Allergy Asthma Clin. Immunol. 2011; 7 (1): 4.
  12. Ilonidis G., Agorastos I., Anogianakis G. et al. Bronchial hyperreactiviti in patients with inflammatory bowel disease . In: Abstracts of the 13th ERS Annual Congress. Vienna, Austria; 2003; Eur. Respir. J. 2003; 22 (Suppl. 45): 480.
  13. Vighi G., Marcucci F., Sensi L., Di Cara G., Frati F. Allergy and the gastrointestinal system. Clin. Exp. Immunol. 2008; 153 (Suppl. 1): 3-6.
  14. GINA Report, Global Strategy for Asthma Management and Prevention. Published November 2009. http://www.ginasthma.org/
  15. Kononov A.V., Mozgovoi S.I., Shimanskaya A.G., Markelova M.V., Osintseva I.L., Vas'kina T.V., Panyushkin L.V. Rossiiskii peresmotr klassifikatsii khronicheskogo gastrita: vosproizvodimost' otsenki patomorfologicheskoi kartiny. Arkhiv patologii. 2011; 73 (4): 52-6.
  16. Aruin L.I., Kononov A.V., Mozgovoi S.I. Novaya klassifikatsiya khronicheskogo gastrita. Arkhiv patologii. 2009; 71 (4): 11-7.
  17. Kononov A.V., Mozgovoi S.I., Markelova M.V., Shimanskaya A.G. Morfogenez atrofii slizistoi obolochki zheludka kak osnova fenotipa khronicheskogo gastrita. Arkhiv patologii. 2011; 73 (3): 26-31.
  18. Shimanskaya A.G. Morfologicheskie metody i ekspertnyi podkhod pri verifikatsii atrofii slizistoi obolochki zheludka v biopsiinoi diagnostike atroficheskogo gastrita. Molodoi uchenyi. 2012; 4: 496-505.
  19. Shcherbakov I.T. Patomorfologiya slizistoi obolochki zheludochno-kishechnogo trakta pri ostrykh bakterial'nykh, virusnoi kishechnykh infektsiyakh i khronicheskikh kolitakh: Dis. ... d-ra med. nauk. M.; 1995. 539 s.
  20. Avtandilov G.G. Meditsinskaya morfometriya: Rukovodstvo. M.: Meditsina; 1990. 384 s.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.