The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Neymark M.I.

Altai State Medical University;
Barnaul Clinical Hospital «Russian Railways-Medicine»

Kloster E.A.

Barnaul Clinical Hospital «Russian Railways-Medicine»

Bulganin A.A.

Altai State Medical University;
Barnaul Clinical Hospital «Russian Railways-Medicine»

Optimizing the treatment of diabetic ketoacidosis

Authors:

Neymark M.I., Kloster E.A., Bulganin A.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(2): 67‑77

DOI: 10.17116/anaesthesiology202402167

Read: 1991 times

Download PDF (RU)
Contact the author
Table of contents

OPTIMIZING THE TREATMENT OF DIABETIC KETOACIDOSIS
OPTIMIZING THE TREATMENT OF DIABETIC KETOACIDOSIS

To cite this article:

Neymark MI, Kloster EA, Bulganin AA. Optimizing the treatment of diabetic ketoacidosis. Russian Journal of Anesthesiology and Reanimatology. 2024;(2):67‑77. (In Russ.)
https://doi.org/10.17116/anaesthesiology202402167

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Effect of infu­sion therapy volume on the first day after gastropancreatoduodenal rese­ction on imme­diate outcomes. Russian Journal of Anesthesiology and Reanimatology. 2025;(2):13-19
The role of quantitative body composition analysis in popu­lation in the asse­ssment and moni­toring of cardiovascular risk meta­bolic factors. Russian Journal of Preventive Medi­cine. 2024;(12):128-134
Restoration of spermatogenesis suppressed by the use of testosterone, antiestrogen therapy in men with type 2 diabetes mellitus. Russian Journal of Human Reproduction. 2024;(6):156-160
Diabetic reti­nopathy and pregnancy. Russian Annals of Ophthalmology. 2024;(6):145-151
Psoriasis: analysis of como­rbid pathology. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(1):16-21
Cognitive functions asse­ssment of elde­rly patients with type 2 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):46-50
Features of comprehensive treatment in a patient with complicated type 2 diabetes mellitus: A clinical case. Piro­gov Russian Journal of Surgery. 2025;(6):128-132
Early diagnosis and effe­ctive therapy of diabetic poly­neuropathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):62-68
Hype­rtensive diso­rders of pregnancy as a risk factor for chro­nic non-communicable diseases. Russian Journal of Preventive Medi­cine. 2025;(6):114-119
Cere­brovascular disease in clinical practice. Reso­lution of the Expert Council of the Russian Scientific Medi­cal Society of Therapists. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):105-111
Abstract:

Solutions for infusion therapy of diabetic ketoacidosis are currently discussable. The advantages of balanced crystalloid solutions require further evidence that dictates the need for additional research.

OBJECTIVE

To justify advisability of meglumine sodium succinate (Reamberin) in infusion therapy of diabetic ketoacidosis.

MATERIAL AND METHODS

A prospective study included 100 patients with diabetes mellitus complicated by diabetic ketoacidosis. Patients were divided into 2 groups depending on infusion therapy: group 1 — saline solution, group 2 — meglumine sodium succinate (Reamberin) 10 ml/kg daily. We analyzed control indicators of treatment, speed of achieving these indicators and acid-base state.

RESULTS

The best results were achieved in the second group. Median period of diabetic ketoacidosis was 42 and 34 hours, respectively. Accordingly, time of intravenous insulin infusion was 44 and 34 hours, respectively. ICU-stay was 52 and 46 hours, respectively. Dynamics of acid-base state indicators was slower in the first group compared to normalization rate in the second group.

CONCLUSION

Meglumine sodium succinate (Reamberin) in intensive therapy of diabetic ketoacidosis improved treatment outcomes and acid-base normalization rate due to succinate buffer and succinic acid metabolism. Regression of acid-base abnormalities is accelerated.

Keywords:

diabetes mellitus
diabetic ketoacidosis
crystalloid solution
infusion therapy
meglumine sodium succinate (Reamberin)

Authors:

Neymark M.I.

Altai State Medical University;
Barnaul Clinical Hospital «Russian Railways-Medicine»

Kloster E.A.

Barnaul Clinical Hospital «Russian Railways-Medicine»

Bulganin A.A.

Altai State Medical University;
Barnaul Clinical Hospital «Russian Railways-Medicine»

Received:

08.12.2023

Accepted:

22.01.2024

Close metadata

References:

  1. Zabolotskikh IB, Protsenko DN. Intensivnaya terapiya: natsional’noe rukovodstvo. T. 2. 2-e izd., pererab. i dop. M.: GEOTAR-Media; 2022. (In Russ.).
  2. Algoritmy spetsializirovannoj meditsinskoj pomoshchi bol’nym sakharnym diabetom. Dedov II, Shestakova MV, Mayorov AYu, eds. 11-j vypusk. M. 2023. (In Russ.). https://doi.org/10.14341/DM13042
  3. Zabolotskikh IB, Malyshev YuP, Dunts PV, Lebedinskii KM, Leyderman IN, Neymark MI, Semenikhina TM, Yaroshetsky AI. Perioperative management of adult patients with concomitant diabetes mellitus: guidelines of the All-Russian public organization «Federation of Anesthesiologists and Reanimatologists» (second revision). Annals of Critical Care. 2023;1:14-33. (In Russ.). https://doi.org/10.21320/1818-474X-2023-1-14-33
  4. Roizen MF, Fleisher LA. Perioperative management of patients with concomitant diseases. In: Anesteziya. Miller’s Anesthesia. Miller RD, ed. SPb: Chelovek; 2015(V. 2):1139-1234. (In Russ.).
  5. Simutis IS, Boyarinov GA, Yuryev MYu, Petrovsky DS, Kovalenko AL, Sapozhnikov KV. A new look at the correction of COVID-19- mediated pulmonary gas exchange disorders. Kazanskij meditsinskij zhurnal. 2021;102(3): 362-372. (In Russ.). https://doi.org/10.17816/KMJ2021-362
  6. Handy JM, Soni N. Physiological effects of hyperchloraemia and acidosis. British Journal of Anaesthesia. 2008;101(2):141-150.  https://doi.org/10.1093/bja/aen148
  7. Simutis IS, Boyarinov GA, Yuriev MYu, Petrovsky DS, Kovalenko AL, Sapozhnikov KV. Meglumine sodium succinate to correct COVID-19-associated coagulopathy: the feasibility study. General Reanimatology. 2021;17(3): 50-64. (In Russ.). https://doi.org/10.15360/1813-9779-2021-3-50-64
  8. Kovalenko AL, Rizakhanov DM, Yakovlev AYu, Simutis IS, Parfenov SA, Bobovnik SV, Sorokin EP, Plexov AV, Afonchikov VS, Lebedinskii KM. Preliminary results of adding meglumine sodium succinate to the treatment of patients with moderate and severe acute pancreatitis. General Reanimatology. 2021;17(1):46-56. (In Russ.). https://doi.org/10.15360/1813-9779-2021-1-0-1
  9. Eledrisi MS, Elzouki A-N. Management of diabetic ketoacidosis in adults: A narrative review. Saudi Journal of Medicine and Medical Sciences. 2020; 8(3):165-173.  https://doi.org/10.4103/sjmms.sjmms_478_19
  10. Kirov MYu, Gorobets ES, Bobovnik SV, Zabolotskikh IB, Kokhno VN, Lebedinskii KM, Lomivorotov VV, Lubnin AYu, Moroz GB, Musaeva TS, Neimark MI, Schegolev AV. Principles of perioperative infusion therapy in adults. Anesteziologiya i Reanimatologiya. 2018;6:82-103. (In Russ.). https://doi.org/10.17116/anaesthesiology201806182
  11. Marino PL. Marino’s the ICU book. Yaroshetsky AI, ed. M.: GEOTAR-Media; 2022. (In Russ.).
  12. Mæhle K, Haug B, Flaatten H, Nielsen E. Metabolic alkalosis is the most common acid-base disorder in ICU patients. Critical Care. 2014;18(2):420.  https://doi.org/10.1186/cc13802
  13. Spichak II, Kopytova EV. Application of polyionic reamberin solution in medicine and experience with its use in pediatric oncology. Onkologiya. Zhurnal im. P.A. Gertsena. 2018;7(5):47-55. (In Russ.). https://doi.org/10.17116/onkolog2018705147
  14. Shakh BN, Lapshin VN, Kyrnyshev AG, Smirnov DB, Kravchenko-Berezhnaya NR. Metabolic effects of a succinic acid. General Reanimatology. 2014;10(1):33-42. (In Russ.). https://doi.org/10.15360/1813-9779-2014-1-33-42
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.