Postoperative analgesia with a fixed combination of diclofenac and orphenadrine in thoracic surgery

Yavorovskiy AG, Nogtev PV, Ovechkin AM, et al. . Postoperative analgesia with a fixed combination of diclofenac and orphenadrine in thoracic surgery. Russian Journal of Anesthesiology and Reanimatology. 2023;(4):81‑87. (In Russ.)
https://doi.org/10.17116/anaesthesiology202304181

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OBJECTIVE

Evaluation of the effectiveness and safety of fixed combination of 30 mg orphenadrine and 75 mg diclofenac (Neodolpasse) for postoperative analgesia of thoracic surgery patients.

MATERIAL AND METHODS

There were two analgesia regimens evaluated in an observational randomized prospective single-center study included 40 thoracic surgery patients. Neodolpasse was administered immediately after trachea extubation for 20 patients of the 1st group. Ketoprofen 100 mg 2 times per day was administered for 20 patients of the 2nd group. In both groups analgesia was also provided by morphine hydrochloride using patient-controlled analgesia (PCA).

RESULTS

Decreasing of pain was reached after 1 hour of observation for patients of the 1st group with Neodolpasse. Decreasing of pain for the patients of the 2nd group was reached just after 6 hours. The mean visual-analog scale score was significantly lower for patients of the 1st group comparing to the 2nd group during all period of observation. Morphine hydrochloride using PCA was administered to the 2nd group three times more than for the 1st group of patients with Neodolpasse. Maximum inspiratory capacity of the lungs was increased more in the 1st group of patients with Neodolpasse. Adverse events were significantly less in the 1st group compared to the 2nd group. Nephrotoxicity was not observed in both groups.

CONCLUSION

The study demonstrated the safety, high analgesic effect and significant opioid-sparing effect of Neodolpasse in the early postoperative period in thoracic surgery patients.

Keywords:

thoracotomy

postoperative pain

diclofenac

orphenadrine

patient-controlled analgesia

Authors:

Yavorovskiy A.G.

Sechenov First Moscow State Medical University

ORCID: 0000-0001-5103-0304

Nogtev P.V.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-5553-0880

Ovechkin A.M.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-3453-8699

Bagdasarov P.S.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-1917-7493

Polukhin N.V.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-9540-5793

Sergeev O.S.

Belgorod State University

ORCID: 0009-0008-4669-0453

Aliev V.A.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-2089-7076

Zolotova E.N.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-1608-6131

Yavorovskaya D.A.

Sechenov First Moscow State Medical University

ORCID: 0009-0009-0329-153X

Received:

30.05.2023

Accepted:

15.06.2023

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