The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Semenkov A.V.

Moscow Regional Research Clinical Institute named after M.F. Vladimirsky;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Bogdanov-Berezovsky A.A.

Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Skugarev A.L.

Moscow Regional Research and Clinical Institute («MONIKI»)

Tulskih D.A.

Moscow Regional Scientific Research Clinical Institute named after M.F. Vladimirsky

Use of a fixed combination of diclofenac and orphenadrine (Neodolpasse) for postoperative analgesia after extended gastrectomy with resection of the lower third of the esophagus

Authors:

Semenkov A.V., Bogdanov-Berezovsky A.A., Skugarev A.L., Tulskih D.A.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2025;14(2): 52‑56

DOI: 10.17116/onkolog20251402152

Read: 642 times

Buy for 300₽
Contact the author
Table of contents

USE OF A FIXED COMBINATION OF DICLOFENAC AND ORPHENADRINE (NEODOLPASSE) FOR POSTOPERATIVE ANALGESIA AFTER EXTENDED GASTRECTOMY WITH RESECTION OF THE LOWER THIRD OF THE ESOPHAGUS
USE OF A FIXED COMBINATION OF DICLOFENAC AND ORPHENADRINE (NEODOLPASSE) FOR POSTOPERATIVE ANALGESIA AFTER EXTENDED GASTRECTOMY WITH RESECTION OF THE LOWER THIRD OF THE ESOPHAGUS

To cite this article:

Semenkov AV, Bogdanov-Berezovsky AA, Skugarev AL, Tulskih DA. Use of a fixed combination of diclofenac and orphenadrine (Neodolpasse) for postoperative analgesia after extended gastrectomy with resection of the lower third of the esophagus. P.A. Herzen Journal of Oncology. 2025;14(2):52‑56. (In Russ.)
https://doi.org/10.17116/onkolog20251402152

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Transitional pain service in surgery as an opti­mal stra­tegy for the treatment and prevention of chro­nic postoperative pain. Piro­gov Russian Journal of Surgery. 2024;(11):60-64
Reflexotherapy as an effe­ctive component of postoperative pain relief. Russian Journal of Pain. 2024;(4):41-45
Effi­cacy and safety of meta­mizole sodium for pain syndrome in adults and children: a systematic review. Russian Journal of Pain. 2024;(4):65-80
Pharmacological pain mana­gement in pediatric inte­nsive care. Russian Journal of Pain. 2025;(1):56-61
Psychosensory anatomo-functional auto­desadaptation syndrome as a predictor of pain in patients after orthognathic surgery. Russian Rhinology. 2025;(1):42-47
Novel opioids in postoperative pain mana­gement. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):78-84
Abstract:

The presented clinical case demonstrated the successful management of acute postoperative pain syndrome with a short course of a fixed combination of diclofenac 75 mg and orphenadrine 30 mg (Neodolpasse) in a patient diagnosed with Primary Multiple Metachronous Cancer (PMMC): 1. Gastric cancer pT3N0M0 stage IIA 2. Right lung cancer pT1aN1M0 stage I, upper right lobectomy in 2017, in the postoperative period after extended gastrectomy with resection of the lower third of the esophagus by thoracoabdominal access. The treatment, including a short course of Neodolpasse in a multimodal analgesia regimen, resulted in pronounced analgesic and opioid-sparing effects and was accompanied by a good safety profile.

Keywords:

postoperative pain
abdominal oncologic surgery
multimodal analgesia
non-steroidal anti-inflammatory drugs
fixed combination of diclofenac and orphenadrine

Authors:

Semenkov A.V.

Moscow Regional Research Clinical Institute named after M.F. Vladimirsky;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Bogdanov-Berezovsky A.A.

Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Skugarev A.L.

Moscow Regional Research and Clinical Institute («MONIKI»)

Tulskih D.A.

Moscow Regional Scientific Research Clinical Institute named after M.F. Vladimirsky

Received:

26.01.2025

Accepted:

31.01.2025

Close metadata

References:

  1. Garg R, Hariharan U. Multimodal analgesic plans for cancer surgeries. In: Ray MD, ed. Multidisciplinary approach to surgical oncology patients. Springer, Singapore; 2021: 99-111.  https://doi.org/10.1007/978-981-15-7699-7_11
  2. Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, Ripamonti CI.; ESMO Guidelines Committee. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2018;29(Suppl. 4):iv166-iv191. https://doi.org/10.1093/annonc/mdy152
  3. Cata JP, Corrales G, Speer B, Owusu-Agyemang P. Postoperative acute pain challenges in patients with cancer, Best Pract Res Clin Anaesthesiol. 2019;33(3):361-371.  https://doi.org/10.1016/j.bpa.2019.07.018
  4. Skugarev AL, Semenkov AV, Khitrov NV. A systematic review of current trends in quality of life assessment in patients with malignant neoplasms (literature review and clinical guidelines). Clinical Review for General Practice. 2023;4(5):45-57. (In Russ.). https://doi.org/10.47407/kr2023.4.5.00234
  5. Amelin AV, Tereshchenko NM, Gotovchikov AA. Clinical experience with the use of a fixed combination of diclofenac and orphenadrine in the treatment of acute pain syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(8):83-86. (In Russ.). https://doi.org/10.17116/jnevro202112108183
  6. Ushkalova EA, Zyryanov SK, Zatolochina KE. The fixed combination of diclofenac and orphenadrine in the treatment of acute pain syndromes. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(1):100-104. (In Russ.). https://doi.org/10.14412/2074-2711-2020-100-104
  7. Guzanova EV, Zorkova AV, Sorokina TA. The fixed combination of diclofenac and orphenadrine for radicular lower back pain. Russian Journal of Pain. 2024;22(3):74-80. (In Russ.). https://doi.org/10.17116/pain20242203174
  8. Semenkov AV, Skugarev AL, Tul’skikh DA, Khitrov NV, Yavorovskaya DA, Sergeev OS. Pain relief after abdominal oncologic surgery. Evaluation of the effectiveness and safety of a fixed combination of diclofenac and orphenadrine. Pirogov Russian Journal of Surgery. 2024;(9):38-50. (In Russ.). https://doi.org/10.17116/hirurgia202409138
  9. Eremenko AA, Sorokina LS, Ryabova DV, Urbanov AV. Analgesic and opioid-sparing effects of a fixed combination of diclofenac and orphenadrine in the early postoperative period in cardiac surgery patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10):109-115. (In Russ.). https://doi.org/10.17116/jnevro2022122101109
  10. Dahl JL, Gordon D, Ward S, Skemp M, Wochos S, Schurr M. Institutionalizing pain management: the Post-Operative Pain Management Quality Improvement Project. J Pain. 2003;4(7):361-371.  https://doi.org/10.1016/S1526-5900(03)00640-0
  11. Shang AB, Gan TJ. Optimising postoperative pain management in the ambulatory patient. Drugs. 2003;63(9):855-867.  https://doi.org/10.2165/00003495-200363090-00002
  12. Eremenko AA, Sorokina LS. Anesthesia of adult patients in the early period after cardiac surgery. Russian Journal of Pain. 2018;(1):21-27. (In Russ.). https://doi.org/10.25731/RASP.2018.01.004
  13. Drew D, Gordon D, Renner L, Morgan B, Swensen H, Manworren R. The use of «As-Needed» range orders for opioid analgesics in the management of pain: a consensus statement of the American Society of Pain Management Nurses and the American Pain Society. Pain Manag Nurs. 2014;15(2):551-554.  https://doi.org/10.1016/j.pmn.2014.03.001
  14. Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, Carter T, Cassidy CL, Chittenden EH, Degenhardt E, et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016;17(2):131-157.  https://doi.org/10.1016/j.jpain.2015.12.008
  15. Schjerning AM, McGettigan P, Gislason G. Cardiovascular effects and safety of (non-aspirin) NSAIDs. Nat Rev Cardiol. 2020;17(9):574-584.  https://doi.org/10.1038/s41569-020-0366-z
  16. Grosser T, Fries S, FitzGerald GA. Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest. 2006;116(1):4-15.  https://doi.org/10.1172/JCI27291
  17. Todd PA, Sorkin EM. Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1988;35(3):244-285.  https://doi.org/10.2165/00003495-198835030-00004
  18. Barden J, Edwards J, Moore RA, McQuay HJ. Single dose oral diclofenac for postoperative pain. Cochrane Database Syst Rev. 2004;2:CD004768. https://doi.org/10.1002/14651858.CD004768
  19. McNicol ED, Ferguson MC, Schumann R. Single-dose intravenous diclofenac for acute postoperative pain in adults. Cochrane Database Syst Rev. 2018;8(8):CD012498. https://doi.org/10.1002/14651858.CD012498.pub2
  20. Schaffler K, Reitmeir P, Gschanes A, Eggenreich U. Comparison of the analgesic effects of a fixed-dose combination of orphenadrine and diclofenac (Neodolpasse) with its single active ingredients diclofenac and orphenadrine: a placebo-controlled study using laser-induced somatosensory-evoked potentials from capsaicin-induced hyperalgesic human skin. Drugs R D. 2005;6(4):189-199.  https://doi.org/10.2165/00126839-200506040-00001
  21. Sorokina LS, Vyzhigina MA, Semenkov MA, Arkhipova OV, Eremenko AA. Fixed combination of diclofenac and orphenadrine (Neodolpasse) for postoperative pain relief. Review of the results of international and Russian studies. Russian Journal of Anesthesiology and Reanimatology. 2024;(3):74-80. (In Russ.). https://doi.org/10.17116/anaesthesiology202403174
  22. Kiselev DV, Lavrukhin VV. The use of a fixed combination of diclofenac and orphenadrine in the treatment of acute pain syndrome in patients with discogenic lumbosacral radiculopathy and lumboischialgia. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(3):122-129. (In Russ.). https://doi.org/10.17116/jnevro2023123031122
  23. Yavorovskii AG, Nogtev PV, Ovechkin AM, Bagdasarov PS, Polukhin NV, Sergeev OS, Aliev VA, Zolotova EN, Yavorovskaya DA. Postoperative analgesia with a fixed combination of diclofenac and orphenadrine in thoracic surgery. Russian Journal of Anaesthesiology and Reanimatology. 2023;4:81-87. (In Russ.). https://doi.org/10.17116/anaesthesiology202304181
  24. Kuz’mina MV, Shlyk IV, Panafidina VA, Kozhevin AA, Polushin YuS, Krivov VO. The use of a combination of diclofenac and orphenadrine for analgesia in knee replacement. Messenger of Anesthesiology and Resuscitation. 2023;20(5):48-53. (In Russ.). https://doi.org/10.24884/2078-5658-2023-20-5-48-53
  25. Sorokina LS, Ryabova DV, Koshek EA, Eremenko AA. Efficacy and safety of using a fixed combination of Orphenadrine and Diclofenac for postoperative analgesia in cardiac surgery patients. 2022; S.S. Korsakov Journal of Neurology and Psychiatry.122(2):61-67. (In Russ.). https://doi.org/10.17116/jnevro202212202161
  26. Amelin AV, Balyazin VA, Davydov OS, Zyryanov SK, Kiselev DV, Kurushina OV, Medvedeva LA, Tereshchenko NM, Shirokov VA, Kukushkin ML, Yakhno NN. Russian multicenter study of fixed combination of diclofenac and orphenadrine its efficacy and tolerance of in acute non-specific pain and radiculopathy relief. Russian Journal of Pain. 2022;20(1):33-41. (In Russ.). https://doi.org/10.17116/pain20222001133
  27. Eremenko AA, Polushin YuS, Klypa TV, Yavorovskii AG, Karelov AE, Sorokina LS, Babayants AV, Ignatenko OV, Sergeev OS. Expert council resolution on the intermediate results of observational study «Efficacy and safety of Neodolpasse in early postoperative period». Russian Journal of Pain. 2023;21(1):85-87. (In Russ.). https://doi.org/10.17116/pain20232101185
  28. Karelov AE, Khmara VM, Orozaliev IE, Kellarev MK, Petrosyan TG, Karelov DA, Zabolotskii DV. Comparative assessment of analgesic efficacy of diclofenac and orfenadrine combination in abdominal and vertebral surgery. Russian Journal of Anaesthesiology and Reanimatology. 2023;(5):52-57. (In Russ.). https://doi.org/10.17116/anaesthesiology202305152
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.