Accuracy of predictors of perioperative cardiovascular complications in onco-surgery

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OBJECTIVE

To assess the informative value of predictors of potential perioperative cardiovascular complications (CVC) in oncological abdominal surgery.

MATERIAL AND METHODS

We examined 114 patients aged 67 [61—72] years who underwent elective oncological surgery. Perioperative CVCs were recorded. We analyzed prognostic significance of patient characteristics (including calculated cardiac risk indices — CRI) and biomarkers in relation to CVC.

RESULTS

Perioperative CVCs occurred in 13 (11.4%) patients. According to logistic regression, predictors of perioperative CVC were CRI Khoronenko (p=0.0001) and CRI MICA (p=0.0023). AUC for these indices was 0.774 and 0.798, respectively. Preoperative serum NT-proBNP demonstrated higher quality of predictive model: OR 1.0112; 95% CI 1.0054—1.0170; p=0.0001; AUC 0.91. Serum biomarker >257 pg/ml discriminated patients with perioperative CVC with a sensitivity of 84.62% and specificity of 86.17%.

CONCLUSION

Preoperative serum NT-proBNP >257 pg/mL with sensitivity and specificity >80% is a predictor of perioperative CVC after abdominal oncological surgery. Assessment of this marker is appropriate in patients with high and intermediate cardiac risk.

Keywords:

predictors of complications

non-cardiac surgery

perioperative cardiovascular complications

cardiac complications

cardiac risk indices

natriuretic peptides

NT-proBNP

troponin

biomarkers

oncology

Authors:

Sokolov D.A.

Yaroslavl State Medical University;
Regional Clinical Hospital

SPIN RSCI: 9298-7683
Scopus AuthorID: 57225020669
ORCID: 0000-0002-8186-8236

Zhbannikov P.S.

Yaroslavl State Medical University

SPIN RSCI: 4323-7468
Scopus AuthorID: 6503861616
ORCID: 0000-0002-3868-188X

Ganert A.N.

Yaroslavl State Medical University;
Regional Clinical Hospital

SPIN RSCI: 8682-9270
Scopus AuthorID: 57225018697
ORCID: 0000-0001-5816-4620

Larionov S.V.

Yaroslavl State Medical University

ORCID: 0000-0002-8603-8637

Lyuboshevskiy P.A.

Yaroslavl State Medical University;
Regional Clinical Hospital

SPIN RSCI: 6991-9946
ORCID: 0000-0002-7460-9519

Received:

07.02.2023

Accepted:

17.03.2023

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