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Kozlov I.A.

Moscow Regional Research Clinical Institute n.a. M.F. Vladimirskiy

Perioperative cardioprotection in noncardiac surgery: realities and prospects

Authors:

Kozlov I.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2020;(4): 100‑110

DOI: 10.17116/anaesthesiology2020041100

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Table of contents

PERIOPERATIVE CARDIOPROTECTION IN NONCARDIAC SURGERY: REALITIES AND PROSPECTS
PERIOPERATIVE CARDIOPROTECTION IN NONCARDIAC SURGERY: REALITIES AND PROSPECTS

To cite this article:

Kozlov IA. Perioperative cardioprotection in noncardiac surgery: realities and prospects. Russian Journal of Anesthesiology and Reanimatology. 2020;(4):100‑110. (In Russ.)
https://doi.org/10.17116/anaesthesiology2020041100

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Abstract:

Prevention of perioperative cardiac complications in noncardiac surgery is one of the urgent problems of modern medicine. The current data on the epidemiology of postoperative cardiac complications and their clinical and social significance have been analyzed. The efficacy and indications for perioperative cardioprotection of nitrates, calcium channel blockers, α2-agonists, inhalation anesthetics, β-blockers, statins and some other drugs have been analyzed. It was concluded that the range of recommended cardioprotectors is currently limited. The reason for this is the lack of sufficient effectiveness, but also the risk of complications. One of the most effective and safe pharmacological cardioprotectors is exogenous phosphocreatine. It has been established that myocardial ischemia-reperfusion and a number of heart diseases are accompanied by a pronounced deficiency of phosphocreatine. Modern studies have demonstrated that, in addition to the known bioenergetic properties, exogenous phosphocreatine has a complex of extracellular and intracellular effects, including antiapoptotic and antioxidant properties. A review of the main characteristics of exogenous phosphocreatine, which determines the possibility of its use as a perioperionic cardioprotector in patients with high cardiac risk, who cause noncardiac surgery, is presented.

Keywords:

phosphocreatine
cardioprotection
cardiac risk
perioperative cardiac complications
myocardial infarction
noncardiac surgery

Authors:

Kozlov I.A.

Moscow Regional Research Clinical Institute n.a. M.F. Vladimirskiy

Received:

20.05.2020

Accepted:

15.06.2020

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