Purposes — short bowel syndrome (SBS) is the most frequent cause of chronic intestinal failure in children, which is associated with a number of severe complications and still demonstrates high mortality rates. In this article, we present the results of 12-year single-center experience in treatment of SBS. Material and methods. 45 patients with SBS aged from 1 month to 17 years were treated in surgical unit No.2 of the Russian Children’s Clinical Hospital over 12 years. We apply a multidisciplinary approach to the management of children with this disease and apply different algorithms depending on the age of the patient, the SBS variant, and existing complications. We have a home parenteral nutrition (HPN) program for the patients of the first year of life with complicated SBS, who receive PN before and after autologous intestinal reconstructions. We prefer autologous intestinal reconstruction according to the STEP technique. 32 children have been operated to date, 5 of them had a complex SBS and underwent repeated enteroplasty (reSTEP). Results. 10 patients after autologous bowel reconstruction have gained complete enteral autonomy; 13 more children operated within the last 2 years receive maintenance therapy at home and receive PN 2—4 times a week. 4 children with complex SBS still receive reduced PN more than 2 years after the reconstruction, but do not demonstrate a tendency to restore enteral autonomy. All patients have an adequate nutritional status and demonstrate minimization of life-threatening complications. The survival rate was 89%. Catheter-associated blood infection was the cause of all deaths after successful surgeries (5). Conclusion. Children with SBS require multidisciplinary treatment programs. Autologous intestinal reconstruction according to the STEP technique is a well-established non-transplantation method for the treatment of children with the SBS that contributes to the PN reduction and achievement of enteral autonomy in 45% of cases.