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Chernysheva O.O.

Anokhin Research Institute of Normal Physiology

Abramova A.Yu.

Anokhin Research Institute of Normal Physiology;
Evdokimov Moscow State University of Medicine and Dentistry

Toll-like receptors in chronic pain

Authors:

Chernysheva O.O., Abramova A.Yu.

More about the authors

Journal: Russian Journal of Pain. 2022;20(4): 62‑69

DOI: 10.17116/pain20222004162

Views: 1552

Downloaded: 48

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To cite this article:

Chernysheva OO, Abramova AYu. Toll-like receptors in chronic pain. Russian Journal of Pain. 2022;20(4):62‑69. (In Russ.)
https://doi.org/10.17116/pain20222004162

Подписка 2025 (Russian Journal of Pain)
МСФ на ЯМ
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Molecular mechanisms of neuroimmune interactions, e.g. the role of non-specific immunity in chronic pain, are paid a special attention. Toll-like receptors (TLRs), as a part of pattern-recognizing receptor group, are considered among the components of natural immunity response. Among the TLRs ligands, there are pathogen-associated molecular patterns (exogenic pathogens) and damage-associated molecular patterns (DAMPs), mainly expressed due to different stress reactions. Some neuropathic and dysfunctional mechanisms of chronic pain are realized via pathological activation of ion channels by pro-inflammatory mediators, as well as via aseptic inflammation following TLR activation. Further research of TLR role in chronic pain is a prospective direction in development of target medications for chronic pain.

Keywords:

chronic pain
central sensitization
Toll-like receptors
pathogen-associated molecular patterns
damage-associated molecular patterns

Authors:

Chernysheva O.O.

Anokhin Research Institute of Normal Physiology

Abramova A.Yu.

Anokhin Research Institute of Normal Physiology;
Evdokimov Moscow State University of Medicine and Dentistry

Received:

03.08.2022

Accepted:

28.08.2022

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