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Amelin A.V.

Pavlov First Saint Petersburg State Medical University

Balyazin V.A.

Rostov State Medical University

Davydov O.S.

Research Institute of General Pathology and Pathophysiology

Zyryanov S.K.

Peoples’ Friendship University of Russia (RUDN University)

Kiselev D.V.

Yaroslavl State Medical University

Kurushina O.V.

Volgograd State Medical University

Medvedeva L.A.

Petrovsky National Research Center of Surgery

Tereshchenko N.M.

Pavlov First St. Petersburg State Medical University

Shirokov V.A.

Yekaterinburg Medical Scientific Center for Prevention and Health Protection of Industrial Workers

Kukushkin M.L.

Research Institute of General Pathology and Pathophysiology

Yakhno N.N.

Sechenov First Moscow State Medical University

Russian multicenter study of fixed combination of diclofenac and orphenadrine its efficacy and tolerance of in acute non-specific pain and radiculopathy relief

Authors:

Amelin A.V., Balyazin V.A., Davydov O.S., Zyryanov S.K., Kiselev D.V., Kurushina O.V., Medvedeva L.A., Tereshchenko N.M., Shirokov V.A., Kukushkin M.L., Yakhno N.N.

More about the authors

Journal: Russian Journal of Pain. 2022;20(1): 33‑41

DOI: 10.17116/pain20222001133

Views: 2950

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To cite this article:

Amelin AV, Balyazin VA, Davydov OS, et al. . Russian multicenter study of fixed combination of diclofenac and orphenadrine its efficacy and tolerance of in acute non-specific pain and radiculopathy relief. Russian Journal of Pain. 2022;20(1):33‑41. (In Russ.)
https://doi.org/10.17116/pain20222001133

Подписка 2025 (Russian Journal of Pain)
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The article presents the result NEODOLEX study. It was Russian multicenter statistical efficacy and tolerability observation of Neodolpasse which is a fixed combination of the non-steroidal anti-inflammatory drug (NSAID) diclofennac (75 mg) and the muscle relaxant orphenadrine (30 mg) for acute nonspecific back pain and radiculopathy treatment. The study has showed Neodolpasse infusions lead to the fast (after 24 hours) and significant pain regression (more than 50%) in 94% of patients. Depending on the frequency of Neodolpasse use, additional application of other analgesics was required in 21—35% of patients with acute nonspecific back pain and 11—17% of patients with radiculopathy.

Keywords:

acute nonspecific back pain
radiculopathy
analgesia
Diclofenac
Orphenadrine
fixed combination
combination of NSAIDs and muscle relaxant

Authors:

Amelin A.V.

Pavlov First Saint Petersburg State Medical University

Balyazin V.A.

Rostov State Medical University

Davydov O.S.

Research Institute of General Pathology and Pathophysiology

Zyryanov S.K.

Peoples’ Friendship University of Russia (RUDN University)

Kiselev D.V.

Yaroslavl State Medical University

Kurushina O.V.

Volgograd State Medical University

Medvedeva L.A.

Petrovsky National Research Center of Surgery

Tereshchenko N.M.

Pavlov First St. Petersburg State Medical University

Shirokov V.A.

Yekaterinburg Medical Scientific Center for Prevention and Health Protection of Industrial Workers

Kukushkin M.L.

Research Institute of General Pathology and Pathophysiology

Yakhno N.N.

Sechenov First Moscow State Medical University

Received:

31.12.2021

Accepted:

11.01.2022

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