The aim — to study bone mineral density (BMD), microarchitectonics of facial bones, topographic and anatomical features of trigeminal nerve branches in bone channels, and bone metabolism in patients with persistent idiopathic facial pain (PIFP). Methods. topographic and anatomical features and BMD were studied by performing cone-beam computed tomography (CBCT) in 25 people, including women — 18 people (72%), men — 7 people (28%), aged 38 to 65 years. The BMD was estimated by calculating the indices of the cortical layer of the lower jaw and the panoramic index of the lower jaw. The analysis of bone metabolism was carried out by determining the level of total and ionized calcium, phosphorus, 25 (OH)VitD, osteocalcin, alkaline phosphatase, parathyroid hormone. Depending on changes in BMD, patients were divided into 3 groups: normal BMD, osteopenia, and osteoporosis. Results. BMD analysis revealed normal mineral density of facial bones in 2 people (4%), reduction of BMD to osteopenia — in 16 people (64%), osteoporosis was detected in 7 people (25%). The study of markers of bone metabolism in all patients with normal BMD revealed normal indicators. All patients with osteopenia showed a decrease in the level of 25 (OH) VitD to an average level of 21±2.45 ng / ml at normal levels of other markers. Conclusion. It is necessary to expand the range of imaging methods used for a more detailed assessment of the state of the bones of the facial skeleton to improve and accelerate the differential diagnostic search in patients with prosopalgia. The use of vitamin D in the treatment of PIFP requires further research, including it in the complex therapy of chronic pain syndromes.