Place of hypovitaminosis D in the formation of chronic pain syndrome in patients with persistent idiopathic facial pain

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The aim — to study bone mineral density (BMD), microarchitectonics of facial bones, topographic and anatomical features of trigeminal nerve branches in bone channels, and bone metabolism in patients with persistent idiopathic facial pain (PIFP). Methods. topographic and anatomical features and BMD were studied by performing cone-beam computed tomography (CBCT) in 25 people, including women — 18 people (72%), men — 7 people (28%), aged 38 to 65 years. The BMD was estimated by calculating the indices of the cortical layer of the lower jaw and the panoramic index of the lower jaw. The analysis of bone metabolism was carried out by determining the level of total and ionized calcium, phosphorus, 25 (OH)VitD, osteocalcin, alkaline phosphatase, parathyroid hormone. Depending on changes in BMD, patients were divided into 3 groups: normal BMD, osteopenia, and osteoporosis. Results. BMD analysis revealed normal mineral density of facial bones in 2 people (4%), reduction of BMD to osteopenia — in 16 people (64%), osteoporosis was detected in 7 people (25%). The study of markers of bone metabolism in all patients with normal BMD revealed normal indicators. All patients with osteopenia showed a decrease in the level of 25 (OH) VitD to an average level of 21±2.45 ng / ml at normal levels of other markers. Conclusion. It is necessary to expand the range of imaging methods used for a more detailed assessment of the state of the bones of the facial skeleton to improve and accelerate the differential diagnostic search in patients with prosopalgia. The use of vitamin D in the treatment of PIFP requires further research, including it in the complex therapy of chronic pain syndromes.

Keywords:

persistent idiopathic facial pain

vitamin D

osteoporosis

mineral bone density

cone-beam computed tomography

Authors:

Baliazina E.V.

Rostov State medical University, Department of neurology and neurosurgery, Rostov-on-don, Russia

Evusyak O.M.

Rostov State medical University, Department of neurology and neurosurgery, Rostov-on-don, Russia

Kharitonova K.P.

Rostov State medical University, Department of neurology and neurosurgery, Rostov-on-don, Russia

Received:

20.02.2020

Accepted:

28.02.2020

List of references:

Koopman JS, Dieleman JP, Huygen FJ, De Mos M, Martin CG, Sturkenboom MC. Incidence of facial pain in the general population. Pain. 2009;147(1-3):122-127. https://doi.org/10.1016/j.pain.2009.08.023
Parkhomenko EV, Nartov SE, Karpov DYu. Persistent idiopathic facial pain: a difficult path to a complex diagnosis. Rossijskij medicinskij zhurnal. 2017;25(24):1738-1744. (In Russ.).
Maksimova MYu, Fedin PA, Suanova ET, Tyurnikov VM. Neurophysiological features of atypical facial pain. Annaly klinichesskoj i jeksperemental’noj nevrologii. 2013;7(3):9-16. (In Russ.).
Maarbjerg S, Wolfram F, Heinskou TB, Rochat P, Gozalov A, Brennum J, Olesen J, Bendtsen L. Persistent idiopathic facial pain — a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI. Cephalalgia. 2017;37(13):1231-1240. https://doi.org/10.1177/0333102416675618
Sharav Y, Benoliel R. Orofacial pain and headache. Elsevier. Philadelphia; 2008.
McMillan AS, Wong MC, Zheng J, Lam CL. Prevalence of orofacial pain and treatment seeking in Hong Kong Chinese. Journal of Orofacial Pain. 2006;20(3):218-225.
Ruivo MA, Alves MC, Berzin MGR, Berzin F. Prevalence of pain at the head, face and neck and its association with quality of life in general population of Piraciacaba city, Sao Paulo: an epidemiological study. Revisão Dor Sao Paulo. 2015;20(4):15-21.
Mueller D, Obermann M, Yoon M-S, Poitz F, Hansen N, Slomke M-A, Katsarava Z. Prevalence of trigeminal neuralgia and persistent idiopathic facial pain: A population-based study. Cephalalgia. 2011;31(15):1542-1548. https://doi.org/10.1177/0333102411424619
Classification of Orofacial Pain (ICOP). Version 1.0 beta, 2019. Accessed May 16, 2019. Available at: https://www.ihs-headache.org/binary_data/3468_the-international-orofacial-pain-classification-committee-icop-1-beta-for-review.pdf
O’Neill F, Wilkinson G. Persistent idiopathic facial pain. InnovAiT: Education and Inspiration for General Practice. 2013;6(10):629-634. https://doi.org/10.1177/1755738013496402
Rayanova GSh, Akhmadeeva LR. Differential diagnosis of facial pain. Rossijskij medicinskij zhurnal. 2019;9:16-19.(In Russ.).
Zakrzewska JM. Chronic persistent idiopathic facial pain. Neurosurgery Clinics of North America. 2016;27(3):345-351. https://doi.org/10.1016/j.nec.2016.02.012
Cornelissen P, Kleef M, van Mekhail N. Evidence-based interventional pain medicine according to clinical diagnoses. 3. Persistent idiopathic facial pain. Pain Practice. 2009;9(6):443-448.
Ron GI, Elovicova TM, Uvarova LV, Chibisova MA. Digital diagnostics apparently healthy periodontitis on three-dimensional reconstraction of cone beam computed tomography. Problemy stomatologii. 2015;11(3-4):32-37. (In Russ.). https://doi.org/10.18481/2077-7566-2015-11-3-4-32-37
Gomes CC, de Rezende Barbosa GL, Bello RP, Bóscolo FN, de Almeida SM. A comparison of the mandibular index on panoramic and cross-sectional images from CBCT exams from osteoporosis risk group. Osteoporos International. 2014;25:1885-1890. https://doi.org/10.1007/s00198-014-2696-3
Klemetti E, Kolmakov S, Kroger H. Pantomography in assessment of the osteoporosis risk group. Scandinavian Journal of Dental Research. 1994;102:68-72. https://doi.org/10.1111/j.1600-0722.1994.tb01156.x
Benson BW, Prihoda TJ, Glass BJ. Variations in adult cortical bone mass as measured by a panoramic mandibular index. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 1991;71:349-356. https://doi.org/10.1016/0030-4220(91)90314-3
Brasileiro CB, Chalub LL, Abreu MH, Barreiros ID, Amaral TMP, Kakehasi AM, Mesquita RA. Use of cone beam computed tomography in identifying postmenopausal women with osteoporosis. Archives of Osteoporosis. 2017;12(1):26. https://doi.org/10.1007/s11657-017-0314-7
Toroptsova NV. Epidemiologiya, pervichnaya profilaktika i lechenie postmenopauzal’nogo osteoporoza v usloviyah polikliniki: Dis. ...d-ra med. nauk. M. 2007. (In Russ.).
Larsen ER, Mosekilde L, Foldspang A. Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: A pragmatic population-based 3-year intervention study. Journal of Bone and Mineral Research. 2004;19:270-278.
Pigarova EA, Povalyaeva AA, Dzeranova LK, Rozhinskaya LYa. The role of vitamin D in the prevention and treatment of osteoporosis: novel insight into the known issue. Rossijskij medicinskij zhurnal. Medicinskoe obozrenie. 2019;10(2):102-106. (In Russ.).
Atherton K, Berry DJ, Parsons T, Macfarlane GJ, Power C, Hypponen E. Vitamin D and chronic widespread pain in a white middle-aged british population: Evidence from a cross-sectional population survey. Annals of the Rheumatic Diseases. 2009;68(6):817-822. https://doi.org/10.3390/ijms18102170
Lotfi A, Abdel-Nasser AM, Hamdy A, Omran AA, El-Rehany MA. Hypovitaminosis D in female patients with chronic low back pain. Clinical Rheumatology. 2007;26(11):1895-1901. https://doi.org/10.1007/s10067-007-0603-4
Mouyis M, Ostor AJ, Crisp AJ, Ginawi A, Halsall DJ, Shenker N, Poole KE. Hypovitaminosis D among rheumatology outpatients in clinical practice. Rheumatology. 2008;47(9):1348-1351. https://doi.org/10.1093/rheumatology/ken203
Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clinic Proceedings. 2003;78:1463-1470.
Helde-Frankling M, Björkhem-Bergman L. Vitamin D in Pain Management. International Journal of Molecular Sciences. 2017;18(10):2170. https://doi.org/10.3390/ijms18102170

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