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Skvortsova T.Yu.

Bechtereva Human Brain Institute

Savintseva Zh.I.

Bechtereva Human Brain Institute

Kholyavin A.I.

Bechtereva Human Brain Institute

Gurchin A.F.

Bechtereva Human Brain Institute

Zabrodskaya Yu.M.

Polenov Neurosurgical Institute

Magnetic resonance imaging and PET/CT with 11C-methionine for primary central nervous system vasculitis

Authors:

Skvortsova T.Yu., Savintseva Zh.I., Kholyavin A.I., Gurchin A.F., Zabrodskaya Yu.M.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2024;88(6): 71‑76

DOI: 10.17116/neiro20248806171

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Table of contents

MAGNETIC RESONANCE IMAGING AND PET/CT WITH 11C-METHIONINE FOR PRIMARY CENTRAL NERVOUS SYSTEM VASCULITIS
MAGNETIC RESONANCE IMAGING AND PET/CT WITH 11C-METHIONINE FOR PRIMARY CENTRAL NERVOUS SYSTEM VASCULITIS

To cite this article:

Skvortsova TYu, Savintseva ZhI, Kholyavin AI, Gurchin AF, Zabrodskaya YuM. Magnetic resonance imaging and PET/CT with 11C-methionine for primary central nervous system vasculitis. Burdenko's Journal of Neurosurgery. 2024;88(6):71‑76. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20248806171

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)
 
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Primary central nervous system vasculitis is still a challenge due to rarity of disease, unspecific clinical and neurological presentation, as well as low specificity of MRI and laboratory tests.

OBJECTIVE

To present the potential of hybrid neuroimaging in diagnosis of primary central nervous system vasculitis.

MATERIAL AND METHODS

The results of MRI, PET/CT with 11C-methionine, histological and immunochemical data in a 23-year-old patient with first-time epileptic seizure are demonstrated.

RESULTS

MRI revealed multifocal lesion of the left frontal lobe with contrast accumulation, edema and mass effect. The largest lesion demonstrated high 11C-methionine uptake that was typical for tumor. Stereotactic biopsy of this lesion was performed. Morphological examination revealed lymphocytic vasculitis.

CONCLUSION

Radiological and metabolic semiotics of primary central nervous system vasculitis can mimic cerebral tumor. High 11C-methionine uptake in active inflammation focus is valuable to choose the target for biopsy.

Keywords:

primary vasculitis
central nervous system
MRI
PET/CT
11C-methionine

Authors:

Skvortsova T.Yu.

Bechtereva Human Brain Institute

Savintseva Zh.I.

Bechtereva Human Brain Institute

Kholyavin A.I.

Bechtereva Human Brain Institute

Gurchin A.F.

Bechtereva Human Brain Institute

Zabrodskaya Yu.M.

Polenov Neurosurgical Institute

Received:

24.04.2024

Accepted:

20.09.2024

List of references:

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