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Izmailov T.R.

Russian Research Radiology Center;
Pirogov Russian National Research Medical University

Melnik S.Yu.

Russian Research Radiology Center

Early and long-term outcomes of treatment in patients with medulloblastoma

Authors:

Izmailov T.R., Melnik S.Yu.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(5): 57‑62

DOI: 10.17116/neiro20218505157

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Table of contents

EARLY AND LONG-TERM OUTCOMES OF TREATMENT IN PATIENTS WITH MEDULLOBLASTOMA
EARLY AND LONG-TERM OUTCOMES OF TREATMENT IN PATIENTS WITH MEDULLOBLASTOMA

To cite this article:

Izmailov TR, Melnik SYu. Early and long-term outcomes of treatment in patients with medulloblastoma. Burdenko's Journal of Neurosurgery. 2021;85(5):57‑62. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20218505157

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To compare the modes of craniospinal irradiation (CSI) and to determine possible factors improving the outcome in patients with medulloblastoma.

MATERIAL AND METHODS

The study included 92 patients with medulloblastoma who were treated at the Russian Research Radiology Center between 2008 and 2019. Mean age of patients was 12 years. Classical morphological variant of medulloblastoma prevailed (48.4%). After surgery, 78 patients underwent radiotherapy (CSI + full-volume «boost» on the tumor site). Standard risk patients received CSI in a reduced dose after tumor resection. Weekly modification of radiotherapy with vincristine was performed in 73 (79.3%) patients.

RESULTS

We significantly (p<0.05) determined the total focal doses for CSI in patients with medulloblastoma. Total resection of posterior cranial fossa tumor improved relapse-free survival by several times. Complete CSI up to total dose of 36/54 Gy ensures the most positive effect compared to irradiation in reduced dose.

CONCLUSION

Relapse-free survival significantly depends on total focal dose of CSI. Single focal dose, chemotherapeutic modification of radiotherapy and M-stage had no significant effect on relapse-free survival. Perhaps, this is due to small sample size.

Keywords:

medulloblastoma
craniospinal irradiation
radiotherapy
pediatric tumors
neuro-oncology

Authors:

Izmailov T.R.

Russian Research Radiology Center;
Pirogov Russian National Research Medical University

Melnik S.Yu.

Russian Research Radiology Center

Received:

27.07.2020

Accepted:

05.08.2021

Close metadata

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