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Aleksandrova E.V.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Zaĭtsev O.S.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Neurotransmitter basis of consciousness and uncosciousness states

Authors:

Aleksandrova E.V., Zaĭtsev O.S., Potapov A.A.

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Journal: Burdenko's Journal of Neurosurgery. 2014;78(1): 26‑32

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Table of contents

NEUROTRANSMITTER BASIS OF CONSCIOUSNESS AND UNCOSCIOUSNESS STATES
NEUROTRANSMITTER BASIS OF CONSCIOUSNESS AND UNCOSCIOUSNESS STATES

To cite this article:

Aleksandrova EV, Zaĭtsev OS, Potapov AA. Neurotransmitter basis of consciousness and uncosciousness states. Burdenko's Journal of Neurosurgery. 2014;78(1):26‑32. (In Russ., In Engl.)

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
 
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Abstract:

Plenty of different studies are dedicated to consciousness recovery problem, such as neuroanatomical, neurophysiological, neuropsychiatric, neurosurgical, neurological points of view. However, neurotransmitter dysfunction is one of the main difficulties for consciousness and other neurological functions recovery after brain trauma. There are a lot of pharmacological agents modulating brain neurotransmitter activity, but no one precise clinical indication. So, the neurotransmitter mechanisms of consciousness recovery in patients with brain pathologies are very actual for studying with updating methods. This review concerns to the current understanding of unconsciousness, neuroanatomical and neurotransmitter bases of the last one.

Keywords:

traumatic brain injury
consciousness recovery
uncosciousness states
neurotransmitters

Authors:

Aleksandrova E.V.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Zaĭtsev O.S.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

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References:

  1. Aleksandrova E.V., Zaytsev O.S., Tenedieva V.D., Potapov A.A., Zakharova N.E., Kravchuk A.D., Oshorov A.V., Sokolova E.Yu., Shurkhay В.A., Vorob’ev Yu.V. Catecholamines in plasma during recovery of consciousness in patients with severe traumatic brain injury. Zhurn nevrol i psychiatr 2011, 3: 58-63. In Russian.
  2. Barkhatova V.P. Neurotransmitters and extrapyramidal pathology. Moscow: Meditsina 1988. In Russian.
  3. Zaytsev O.S. Selection of neurometabolic treatment of severe traumatic brain injury. Zhurn nevrol i psychiatr 2010, 9: 66-69. In Russian.
  4. Zaytsev O.S. Psychopathology of severe traumatic brain injury. Moscow: MEDpress Inform 2011. In Russian.
  5. Zaytsev O.S., Tsarenko S.V. Neuroreanimatology. Recovery from coma (therapy of post-coma states). Mowcow: Litass 2012. In Russian.
  6. Bales J.W., Wagner А.К., Kline А.Е., Dixon С.Е. Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis. Neurosci Biobehav Rev 2009; 33: 981-1003.
  7. Bayer L. et al. Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons. J Neurosci 2002; 22: 7835-7839.
  8. Bogen J.E. On the neurophysiology of consciousness: I. An overview. Conscious Cogn 1995; 4: 1: 52-62.
  9. Bohland J.W., Wu C., Barbas H. et al. A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Comput Biol 2009; 5:el000334.
  10. Buzsáki G., Bickford R.G., Armstrong D.M., Ponomareff G., Chen K.S., Ruiz R., Thai L.J., Gage F.H. Electric activity in the neocortex of freely moving young and aged rats. Neuroscience 1988; 26: 3: 735-744.
  11. Bymaster F.P., Katner J.S., Nelson D.L., Hemrick-Luecke S.K., Threlkeld P.G., Heiligenstein J.H., Morin S.М., Gehlert D.R., Perry K. W. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 2002; 5: 699- 711.
  12. Carboni E., Tanda G.L., Frau R., Di Chiara G. Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals. J Neurochem 1990; 55: 1067-1070.
  13. Chou T.C., Bjorkum A.A., Gaus S.E., Lu J., Scammell T.E., Saper C.B. Afferents to the ventrolateral preoptic nucleus. J Neurosci 2002; 22: 3: 977-990.
  14. Crick F., Koch C. The problem of consciousness. Sci Am 1992; 267: 3: 152-159.
  15. Crosson B.H.K. Subcortical functions in cognition: toward a consensus. J Int Neuropsychol Soc 2003; 9: 1027-1030.
  16. Devoto P., Flore G., Pani L., Gessa G.L. Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex. Mol Psychiatr 2001; 6: 657-664.
  17. Devoto P., Flore G., Saba P., Fá М., Gessa G.L. Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex. J Neurochem 2005; 92: 368-374.
  18. Franks N.P. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nature Rev 2008; 370-386.
  19. Fuller P., Sherman D., Pedersen N.P., Saper C.B., Lu J. Reassessment of the Structural Basis of the Ascending Arousal System. J Comparat Neurol Res Systems Neurosci 2011; 519: 933-956.
  20. Gallopin T. et al. Identification of sleep-promoting neurons in vitro. Nature 2000; 404: 992-995.
  21. Grillner S., Hellgren J., Munard A., Saitoh K., Wikstrum M.A. Mechanisms for selection of basic motor programs-roles for the striatum and pallidum. Trends Neurosci 2005; 28: 364-370.
  22. Неппу P., Jones B.E. Innervation of orexin/ hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins. J Comp Neurol 2006; 499: 645-661.
  23. Inagaki N., Yamatodani A., Ando-Yamamoto М., Tohyama М., Watanabe Т., Wada H. Organization of histaminergic fibers in the rat brain. J Comp Neurol 1988; 273: 3: 283-300.
  24. Jones B.E., Yang T.Z. The efferent projections from the reticular formation and the locus coeruleus studied by anterograde and retrograde axonal transport in the rat. J Comp Neurol 1985; 242: 1: 56-92.
  25. Kinomura S., Larsson J., Gulybs B., Roland P.E. Activation by attention of the human reticular formation and thalamic intralaminar nuclei. Science 1996; 271: 512-515.
  26. Krout K.E., Belzer R.E., Loewy A.D. Brainstem projections to midline and intralaminar thalamic nuclei of the rat. J Comp Neurol 2002; 448: 1: 53-101.
  27. Lacey C.J., Bolam J.P., Magill P.J. Novel and distinct operational principles of intralaminar thalamic neurons and their striatal projections. J Neurosci 2007; 27: 4374-4384.
  28. Laureys S., Boly M., Maquet P. Tracking the recovery of consciousness from coma. J Clin Invest 2006; 7: 1823-1825.
  29. Laureys S. et al. Impaired effective cortical connectivity in vegetative state: preliminary investigation using PET. Neuroimage 1999; 9: 377-382.
  30. Laureys S., Tononi G. The neurology of consciousness. Elsevier Ltd 2009.
  31. Laureys S., Faymonville M.E., Moonen G., Luxen A., Maquet P. PET scanning and neuronal loss in acute vegetative state. Lancet 2000; 355: 1825-1826.
  32. Lindvall O., Bjorklund A. The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta Physiol Scand 1974; 412: Suppl: 1-48.
  33. Lu J., Chou T.C., Saper C.B. Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray. Soc Neurosci Prog 2002; Abstr: 871-878.
  34. McGinty D. et al. Sleep-promoting functions of the hypothalamic median preoptic nucleus: inhibition of arousal systems. Arch Ital Biol 2004; 142: 501-509.
  35. Meredith G.E., Wouterlood F.G. Hippocampal and midline thalamic fibers and terminals in relation to the choline acetyltransferase-immunoreactive neurons in nucleus accumbens of the rat: a light and electron microscopic study. J Comp Neurol 1990; 296: 2: 204-221.
  36. Methippara M.M., Alam M.N., Szymusiak R., McGinty D. Preoptic area warming inhibits wake-active neurons in the perifornical lateral hypothalamus. Brain Res 2003; 960: 165-173.
  37. Michelson D., Allen A.J., Busner J., Casat C., Dunn D., Kratochvil C., Newcorn J., Sallee F.R., Sangal R.B., Saylor K., West S., Kelsey D., Wernicke J., Trapp N.J., Harder D. Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: a randomized, placebo-controlled study. Am J Psychiatr 2002; 11: 1896-1901.
  38. Modirrousta М., Mainville L., Jones B.E. Gabaergic neurons with α2-adrenergic receptors in basal forebrain and preoptic area express c-Fos during sleep. Neurosci 2004; 129: 803-810.
  39. Nagai Y., Critchley H.D., Featherstone E., Fenwick P.B., Trimble M.R., Dolan R.J. Brain activity relating to the contingent negative variation: an fMRI investigation. Neuroimage 2004; 21: 1232-1241.
  40. Nelson L.E., Guo T.Z., Lu J., Saper C.B., Franks N.P., Maze M. The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci 2002; 5: 10: 979-984.
  41. О‘Donohue. Biochemical mapping of the noradrenergic ventral bundle projection sites: evidence for a noradrenergic-dopaminergic interaction. Brain Res 1979; 1: 87-100.
  42. Panula P., Pirvola U., Auvinen S., Airaksinen M.S. Histamine-immunoreactive nerve fibers in the rat brain. Neuroscience 1989; 28: 3: 585-610.
  43. Parker S.A., Serrats A.F. Memory recovery after traumatic coma. Acta Neurochir (Wien) 1976; 1-4: 71-77.
  44. Parvizi J., Damasio A. Neuroanatomical correlates of brainstem coma. Brain 2003; 126: 1524-1536.
  45. Patrick P.D., Blackman J.A., Mabry J.L., Buck M.L., Gurka M.J., Conaway M.R. Dopamine agonist therapy in low-response children following traumatic brain injury. J Child Neurol 2006; 21: 879-885.
  46. Paus Т., Koski L., Caramanos Z., Westbury C. Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex: a review of 107 PET activation studies. Neuroreport 1998; 9: R37-R47.
  47. Paus Т., Zatorre R.J., Hofle N. et al. Time-related changes in neural systems underlying attention and arousal during the performance of an auditory vigilance task. J Cogn Neurosci 1997; 9: 392-408.
  48. Pennartz C.M., Kitai S. T. Hippocampal inputs to identified neurons in an in vitro slice preparation of the rat nucleus accumbens: evidence for feed-forward inhibition. J Neurosci 1991; 11:9: 2838-2847.
  49. Perry E., Ashton Young A. Neurochemistry of consciousness. Ed. S. Greenfield. John Benjamins Publishing Company 2002.
  50. Peyron C. et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998; 18: 9996-10015.
  51. Plum F., Posner J.B. The diagnosis of stupor and coma. 3-rd ed. Philadelphia: F. Davis 1980.
  52. Posner J., Stewart J., Rieder R. Neurobiological formulations: integrating clinical and biological psychiatry. Acad Psychiatr 2007; 31:6: 479-484.
  53. Reid W.M., Hamm R.J. Post-injury atomoxetine treatment improves cognition following experimental traumatic brain injury. J Neurotrauma 2008; 25: 248-256.
  54. Ripley D.L. Atomoxetine for individuals with traumatic brain injury. J Head Trauma Rehabil 2006; 21:1: 85-88.
  55. Saper C.B., Scammell T.E., Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature 2005; 437: 1257-1263.
  56. Schiff N.D., Giacino J.T., Kalmar K. et al. Behavioral improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007; 448: 600-603.
  57. Schiff N.D. Central thalamic contributions to arousal regulation and neurological disorders of consciousness. Ann NY Acad Sci 2008; 1129: 105-118.
  58. Schiff N.D. Recovery of consciousness after brain injury: a mesocircuit hypothesis. Trends Neurosci 2010; 33: 1-9.
  59. Schiff N.D. Recovery of consciousness after severe brain injury: The role of arousal regulation mechanisms and some speculation on the heart-brain interface. Cleveland Clin J Med 2010b; 77: 3: 27-33.
  60. Semba K., Reiner P.B., McGeer E.G., Fibiger H.C. Brainstem afferents to the magnocellular basal forebrain studied by axonal transport, immunohistochemistry, and electrophysiology in the rat. J Comp Neurol 1988; 267: 433-453.
  61. Sherin J.E., Elmquist J.K., Torrealba F., Saper C.B. Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J Neurosci 1998; 18: 4705-4721.
  62. Smith Y., Raju D., Nanda B., Pare J.F., Galvan A., Wichmann T. The thalamostriatal systems: anatomical and functional organization in normal and parkinsonian states. Brain Res Bull 2009; 78: 60-68.
  63. Stahl S.M. Neurotransmission of cognition, pt I: Dopamine is a hitchhiker in frontal cortex: Norepinephrine transporters regulate dopamine (Brainstorms). J Clin Psychiatry 2003; 64: 4-5.
  64. Steininger T.L., Gong H., McGinty D., Szymusiak R. Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups. J Comp Neurol 2001; 429: 638-653.
  65. Steriade М., Glenn L.L. Neocortical and caudate projections of intralaminar thalamic neurons and their synaptic excitation from midbrain reticular core. J Neurophysiol 1982; 48: 352-371.
  66. Suntsova N., Szymusiak R., Alam M.N., Guzman-Marin R., McGinty D. Sleep-waking discharge patterns of median preoptic nucleus neurons in rats. J Physiol 2002; 543: 665-677.
  67. Szymusiak R., McGinty D. Sleep-waking discharge of basal forebrain projection neurons in cats. Brain Res Bull 1989; 22: 423-430.
  68. Szymusiak R. Magnocellular nuclei of the basal forebrain: substrates of sleep and arousal regulation. Sleep 1995; 18: 478-500.
  69. Szymusiak R., Alam N., Steininger T.L., McGinty D. Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats. Brain Res 1998; 803: 178-188.
  70. Uschakov A., Gong H., McGinty D., Szymusiak R, Efferent projections from the median preoptic nucleus to sleep- and arousal-regulatory nuclei in the rat brain. Neuroscience 2007; 150: 104-120.
  71. Van der Werf Y.D., Witter M.P., Groenewegen H.J. The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Res Brain Res Rev 2002; 39: 107-140.
  72. Webster R.A. Neurotransmitters, drugs and brain functions. Ed. R.A. Webster 2001.
  73. Zeman A. Consciousness. Brain 2001; 7: 1263-1289.
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